Quercetin in men with category III chronic prostatitis: a preliminary prospective, double-blind, placebo-controlled trial

Acupuncture and Traditional Chinese Medicine for the management of a 35-year-old man with chronic prostatitis with chronic pelvic pain syndrome

“…9,10,21 Studies now show that oxidative stress plays an important role in CP/CPPS and management with antioxidant therapy, or other methods to lower global oxidative stress and cytokine levels, could be effective in alleviating pain in this population. 11,[21][22][23] …”

“…29 However, reductions in cytokine counts in the prostate gland through antioxidant therapy do correlate with measureable symptomatic improvement in pain and quality of life scores. [9][10][11] …”

“…[8][9][10] Although this does not shed light on the unknown etiology of Category III A and III B prostatitis, studies are now confirming a correlation between measurements of lowered markers of oxidative stress and successful outcomes of treatment in all categories. [9][10][11] These findings are important because they broaden the possible treatment options and also because chronic inflammation is considered a risk factor for benign prostatic hypertrophy 12 and a higher percentage of men diagnosed with benign prostatic hypertrophy are also diagnosed with prostatitis. 8,13 It is suggested that chronic inflammation can promote prostate growth 13 or prostate growth may predispose a patient to bladder and prostate infections by causing incomplete bladder voiding.…”

Clinical phenotyping in chronic prostatitis/chronic pelvic pain syndrome and interstitial cystitis: a management strategy for urologic chronic pelvic pain syndromes

“…16 There are several therapies that can be effective for prostate and bladder injury and inflammation. Quercetin 17 and bee pollen can improve symptoms and inflammation in CPPS as well lowering oxidative stress. 18 Therapies used with varying success for bladder specific injury in IC/PBS include quercetin, 19 misprostol, 20 pentosan polysulfate, intravesical therapy (for example, dimethyl sulfoxide, alkalinization, alkalized lidocaine, heparin, steroids), dietary modifications, restriction of offending agents (for example, nonsteroidal anti-inflammatory drugs 21 ) and surgery for definitive indications (for example, electrocoagulation of Hunner's ulcers).…”

Management of prostatitis

“…Phytotherapies such as quercetin (a bioflavonoid), 38 pentosan polysulfate, 5 systemic medications (gabapentin, tricyclic antidepressants, and striated muscle relaxants), and stress reduction therapy have also been tried. Quercetin has been reported to result in symptom relief in 67% of patients in a preliminary double-blind placebo trial.…”