Quercetin improves the imbalance of Th1/Th2 cells and Treg/Th17 cells to attenuate allergic rhinitis

Xia, Ke; Chen, Ziqi; Wang, Xiaoqiang; Kang, Hou‐Yong; Hong, Suling

doi:10.1080/08916934.2023.2189133

Cited by 15 publications

(7 citation statements)

References 36 publications

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“…Focusing on the pathway level, we discovered that TZD exerts its therapeutic effect on AR through a modular regulation mechanism, including Allergic Reaction and Inflammatory Response, T Cell Immunity and Differentiation, Immune Cell Mobility and Response, Phagocytosis and Antigen Presentation, as well as Cell Signaling and Communication (Figure 2B). In these modules, pathways like Th1 and Th2 cell differentiation were reported to play dominant roles in AR 27,28 , which also served as important intervention targets in the treatment of AR. A shift Th1/Th2 balance towards IL-4 (Th2) has been linked to the onset of allergic and atopic diseases, like AR 29 .…”

Section: Resultsmentioning

confidence: 99%

Clinical multi-omics reveals the role of Tuomin Zhiti Decoction Intervention in Allergic Rhinitis from the perspective of biological network

Zhao,

Wang,

Kong

et al. 2024

Preprint

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Background: Increasing evidence showed that seasonal allergic rhinitis (SAR), as an allergy disease, could be alleviated with traditional Chinese medicine (TCM) formula, one example being Tuomin Zhiti Decoction (TZD). However, as a complex composition of TCM herbs, the mechanism of TZD in the treatment of SAR remain unclear. Purpose: Uncover the mechanism of TZD for treating SAR based on computational analysis and clinical multi-omics experiments. Study design: Integrate computational analysis including network target analysis and machine learning algorithms with clinical multi-omics experiments and public omics data. Methods: By analyzing TZD's composition through a network-based method, we identified the biological effects of each compound, constructing a comprehensive biological network to elucidate TZD's molecular and pathway mechanisms against AR. Single-arm clinical trials on the gut microbiome and serum transcriptomics corroborated our computational insights. Further validation through public omics data highlighted key TZD compounds, paving the way for future research. Results: TZD was discovered to exert a regulatory effect on various modules associated with AR, as demonstrated by the constructed biological network. Insights from gut microbiome and serum transcriptomics in clinical trials, where immune-related microbiomes represented by Prevotella, as well as pathways and biological processes including antigen processing and presentation, activation and regulating immune cell surface receptor, were markedly enriched (P value < 0.05), indicated that TZD played a pivotal role in modulating immune processes and the immune cells against AR. With the verification of multi-omics, it was determined that TZD potentially influences immune responses and downstream immune cells like CD4+ T cells, through both direct mechanisms involving antigen and indirect mechanisms mediated by gut microbiomes in the treatment of AR. Conclusion: Through combination of computational prediction and analysis together with clinical multi-omics, a network target based framework provided a new insight for uncovering the mechanism of TZD for treating AR.

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Section: Resultsmentioning

confidence: 99%

Clinical multi-omics reveals the role of Tuomin Zhiti Decoction Intervention in Allergic Rhinitis from the perspective of biological network

Zhao,

Wang,

Kong

et al. 2024

Preprint

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“…Treg cells act as regulatory antigen presenters through specific ligandreceptor interactions, inhibiting antigen activation and inflammatory responses by immune cells (120). Treg cells also interfere with inflammatory signaling pathways, and can reduce the production of inflammatory factors and inflammatory responses by inhibiting the activation of the nuclear transcription factor NF-kB (122)(123)(124). In addition, some studies have reported that by regulating the TUG1/miR-214/HSP27 signaling pathway, the proportion of Treg cells can be reduced, thereby alleviating acute SCI (125).…”

Section: Treg Cell Regulation Of the Inflammatory Response After Scimentioning

confidence: 99%

Impact of inflammation and Treg cell regulation on neuropathic pain in spinal cord injury: mechanisms and therapeutic prospects

Zhang,

Li,

et al. 2024

Front. Immunol.

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Spinal cord injury is a severe neurological trauma that can frequently lead to neuropathic pain. During the initial stages following spinal cord injury, inflammation plays a critical role; however, excessive inflammation can exacerbate pain. Regulatory T cells (Treg cells) have a crucial function in regulating inflammation and alleviating neuropathic pain. Treg cells release suppressor cytokines and modulate the function of other immune cells to suppress the inflammatory response. Simultaneously, inflammation impedes Treg cell activity, further intensifying neuropathic pain. Therefore, suppressing the inflammatory response while enhancing Treg cell regulatory function may provide novel therapeutic avenues for treating neuropathic pain resulting from spinal cord injury. This review comprehensively describes the mechanisms underlying the inflammatory response and Treg cell regulation subsequent to spinal cord injury, with a specific focus on exploring the potential mechanisms through which Treg cells regulate neuropathic pain following spinal cord injury. The insights gained from this review aim to provide new concepts and a rationale for the therapeutic prospects and direction of cell therapy in spinal cord injury-related conditions.

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“…With particular emphasis on asthma models, kaempferol and rosmarinic acid attenuated airway inflammation by lowering the synthesis of IL-4, Il-5, and Il-13 in the serum and bronchoalveolar lavage fluid (BALF) and effectively reduced the recruitment of eosinophils into lung tissues, airway hyperresponsiveness and hyperproduction of mucus [136,159,160]. Evidence from studies in a mouse model of allergic rhinitis indicated that flavonoids such as quercetin, isoquercetin, myricetin, and luteolin alleviate nasal mucosa inflammation not only by suppressing Th2 cell differentiation and cytokine secretion but also by promoting the Th1 pathway and thus maintaining Th1/TH2 balance [161][162][163][164][165]. Moreover, quercetin as well as tea catechins (ellagitannins and gallic acid) have been shown as effective inhibitors of ovalbumin (OVA)-induced allergic response, stimulating immune tolerance through the Th1/Th2 modulation and induction of regulatory T-cells (Treg) in a mouse models of food allergy [133,162].…”

Section: Effector Phasementioning

confidence: 99%

“…Indeed, in addition to Th1/Th2 dysregulation, disturbance of the balance between Th17/Treg cells contributes to the breakdown of immune tolerance and thus has a role in the enhancement and progression of chronic allergic inflammation [166,167]. Recent experimental studies provided strong evidence that certain flavonoids such as quercetin, luteolin, cyanidin, and baicalin exert an anti-allergic effect by upregulating the number of Tregs and restoring the balance between Th17/Treg [164,[168][169][170]. Similarly, curcumin showed a modulatory effect on Th17/Treg imbalance, effectively reducing the differentiation of Th17 cells while significantly increasing the number of Treg subtypes in a murine model of asthma [171][172][173].…”

Section: Effector Phasementioning

confidence: 99%

Dietary Polyphenols—Natural Bioactive Compounds with Potential for Preventing and Treating Some Allergic Conditions

Dębińska,

Sozańska

2023

Nutrients

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In light of the constantly increasing prevalence of allergic diseases, changes in dietary patterns have been suggested as a plausible environmental explanation for the development and progression of these diseases. Nowadays, much attention has been paid to the development of dietary interventions using natural substances with anti-allergy activities. In this respect, dietary polyphenols have been studied extensively as one of the most prominent natural bioactive compounds with well-documented anti-inflammatory, antioxidant, and immunomodulatory properties. This review aims to discuss the mechanisms underlying the potential anti-allergic actions of polyphenols related to their ability to reduce protein allergenicity, regulate immune response, and gut microbiome modification; however, these issues need to be elucidated in detail. This paper reviews the current evidence from experimental and clinical studies confirming that various polyphenols such as quercetin, curcumin, resveratrol, catechins, and many others could attenuate allergic inflammation, alleviate the symptoms of food allergy, asthma, and allergic rhinitis, and prevent the development of allergic immune response. Conclusively, dietary polyphenols are endowed with great anti-allergic potential and therefore could be used either for preventive approaches or therapeutic interventions in relation to allergic diseases. Limitations in studying and widespread use of polyphenols as well as future research directions are also discussed.

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Quercetin improves the imbalance of Th1/Th2 cells and Treg/Th17 cells to attenuate allergic rhinitis

Cited by 15 publications

References 36 publications

Clinical multi-omics reveals the role of Tuomin Zhiti Decoction Intervention in Allergic Rhinitis from the perspective of biological network

Clinical multi-omics reveals the role of Tuomin Zhiti Decoction Intervention in Allergic Rhinitis from the perspective of biological network

Impact of inflammation and Treg cell regulation on neuropathic pain in spinal cord injury: mechanisms and therapeutic prospects

Dietary Polyphenols—Natural Bioactive Compounds with Potential for Preventing and Treating Some Allergic Conditions

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