Quercetin improves hypoxia-ischemia induced cognitive deficits via promoting remyelination in neonatal rat

Qu, Xuebin; Qi, Dashi; Dong, Fuxing; Wang, Bei; Guo, Rui; Luo, Mengjiao; Yao, Ruiqin

doi:10.1016/j.brainres.2014.01.035

Cited by 52 publications

(32 citation statements)

References 31 publications

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“…Western blotting was carried out as previously described (Qu et al 2014). Briefly, after blocking, the membrane was incubated with anti-Olig2 (Abcam), anti-Oct4 (CST) or anti-b-actin antibodies (Santa Cruz).…”

Section: Western Blottingmentioning

confidence: 99%

Olig2 overexpression accelerates the differentiation of mouse embryonic stem cells into oligodendrocyte progenitor cells in vitro

Yao

Wang

Ren³

et al. 2014

Dev Growth Differ

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Oligodendrocyte progenitor cells (OPCs) transplantation is receiving considerable attention in the field of regenerative medicine therapy for demyelinating diseases. Although embryonic stem cells (ESCs) have been successfully induced to differentiate into OPCs with cytokines cocktails in vitro, the regulatory roles of many key transcription factors in this process are not clear. Here, we introduced oligodendrocyte lineage transcription factor 2 (Olig2), a basic helix-loop-helix transcription factor, into mouse embryonic stem cells (mESCs) to investigate its effects on the differentiation of mESCs into OPCs. The results showed that Olig2 overexpression alone did not affect pluripotency of mESCs, but in the stimulation of differentiating cocktails, Olig2 accelerated mESCs to differentiate into OPCs, shortening the induction time span from normal 21 days to 11 days. Further study demonstrated the Olig2-mESCs derived OPCs were able to differentiate into C-type natriuretic peptid (CNP) and Myelin Basic Protein (MBP) positive mature oligodendrocytes (OLs) in vitro, suggesting these induced OPCs might be favorable for myelin regeneration in vivo.

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Section: Western Blottingmentioning

confidence: 99%

Olig2 overexpression accelerates the differentiation of mouse embryonic stem cells into oligodendrocyte progenitor cells in vitro

Yao

Wang

Ren³

et al. 2014

Dev Growth Differ

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“…Quercetin improved both cognition performance and myelination in perinatal cerebral hypoxia-ischemia-induced brain injury by promoting the proliferation of OPCs and strengthening survival of oligodendrocytes [38]. It acts by inhibiting intramembranous ɤ-secretase, thus interfering with canonical Notch signaling, which leads to enhanced remyelination [3].…”

Section: Priyanga Et Al Reported a Neuroprotective Role Of Quercetin Inmentioning

confidence: 99%

The Role of Lingo-1 and Myelin Basic Protein Mrnas in Central Remyelination in Ethidium Bromide-Induced Demyelination in Rats

Alazrag

Abdelghaffar

Khalifa

et al. 2019

Asian J Pharm Clin Res

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Objective: The study aimed to assess the possible role of quercetin, pioglitazone, metformin, and dapagliflozin in the enhancement of remyelination process after ethidium bromide (EB)-induced demyelination. Methods: The study was conducted on 60 male Wister rats (250–300 g), randomly divided into sham-operated group and five demyelination groups (each of 10 rats) which subjected to intrapontine stereotaxic injection of EB (10 μl of 0.1% EB) to induce demyelination. Then, randomly subdivided into: EB control group: Rats were treated with normal saline, quercetin-treated group (50 mg/kg/day), pioglitazone-treated group (10 mg/kg/day), metformin-treated group (500 mg/kg/day), and dapagliflozin-treated group (10 mg/kg/day). Behavioral tests (beam balance, foot fault, rotarod, and inverted screen) were conducted for all groups as well as biochemical analysis of LINGO-1 and myelin basic protein (MBP) mRNAs and histological examination of pontine tissues. Results: The EB control group showed deterioration of motor performance on behavioral tests. Degenerative changes were observed in pontine tissue on histological examination together with upregulation of LINGO-1 protein and downregulation of MBP level. While the treated groups after EB demyelination showed significant improvement in motor performance and decreased degenerated neurons in histological examination with upregulation of MBP level and downregulation of LINGO-1 protein level. Conclusion: Quercetin, metformin, dapagliflozin, and pioglitazone showed neuroprotective effect and enhancement of remyelination process.

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“…It has been documented to possess anti-inflammatory, anti-ischemic, and neuroprotective properties (Qu et al, 2014) and to exert some protective effects against cadmium-induced toxicity by inhibiting apoptosis and oxidative damage, both in vitro and in vivo (Renugadevi and Prabu, 2010;Wang et al, 2013). It has been documented to possess anti-inflammatory, anti-ischemic, and neuroprotective properties (Qu et al, 2014) and to exert some protective effects against cadmium-induced toxicity by inhibiting apoptosis and oxidative damage, both in vitro and in vivo (Renugadevi and Prabu, 2010;Wang et al, 2013).…”

Section: Quercetinmentioning

confidence: 99%

“…Regarding the nervous system, quercetin has already been shown to be able to improve learning and memory ability, and to be a potential novel therapeutic strategy against AD (Phachonpai et al, 2010). Another particular work studying myelination failure associated with perinatal cerebral hypoxia-ischemia (PHI) and induced brain injury in premature infants demonstrated that quercetin significantly improved cognitive deficits and the behavior of rats with PHI in Morris water maze and open field tasks (Qu et al, 2014). Particularly in AD, amyloid protein and/or amyloid fragments are responsible for the pathophysiology, which involves mitochondrial dysfunction.…”

Section: Quercetinmentioning

confidence: 99%

“…Using rat hippocampal cultures, some authors have already been capable of delivering encapsulated quercetin, protecting neuronal cultures from oxidative stress, and hypothesizing its use against AD or other neurodegenerative disorders (Nday et al, 2015). Additionally, in corpus callosum (CC), the expression of myelin basic protein was increased and the myelin sheaths reached a normal level at 30 days with more compact but less damaged myelin sheaths and more mature oligodendrocytes repopulating the CC compared with PHI groups (Qu et al, 2014). Quercetin and other polyphenols, such as resveratrol, were used in a study to protect brain mitochondria from amyloid fragment fibrillogenesis (Ghobeh et al, 2014).…”

Section: Quercetinmentioning

confidence: 99%

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Mitochondria as a Target for Safety and Toxicity Evaluation of Nutraceuticals

Duarte¹,

Rolo²,

Palmeira³

2016

Nutraceuticals

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Quercetin improves hypoxia-ischemia induced cognitive deficits via promoting remyelination in neonatal rat

Cited by 52 publications

References 31 publications

Olig2 overexpression accelerates the differentiation of mouse embryonic stem cells into oligodendrocyte progenitor cells in vitro

Olig2 overexpression accelerates the differentiation of mouse embryonic stem cells into oligodendrocyte progenitor cells in vitro

The Role of Lingo-1 and Myelin Basic Protein Mrnas in Central Remyelination in Ethidium Bromide-Induced Demyelination in Rats

Mitochondria as a Target for Safety and Toxicity Evaluation of Nutraceuticals

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