Quercetin improved histological structure and upregulated adiponectin and adiponectin receptors in the placenta of rats with gestational diabetes mellitus

Mahabady, Mahmood Khaksary; Shamsi, Mehri; Ranjbar, R; Tabandeh, Mohammad Reza; Khazaeel, Kaveh

doi:10.1016/j.placenta.2021.02.008

Cited by 22 publications

(13 citation statements)

References 66 publications

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“…Liver and kidney histology showed inflammatory, degenerative, and circulatory alterations. We confirmed that QR supplementation significantly reduced GA3-induced hepatorenal damage, in agreement with the observations of Mahabady et al (2021), due to the antioxidant defense of QR (Morand et al, 1998).…”

Section: Organ Lesion and Immunoexpression Cntsupporting

confidence: 90%

Gibberellic acid‐induced hepatorenal dysfunction and oxidative stress: Mitigation by quercetin through modulation of antioxidant, anti‐inflammatory, and antiapoptotic activities

Soliman

Gaber

Alsanie

et al. 2022

Journal of Food Biochemistry

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The plant growth regulator gibberellic acid (GA3) is widely used in agriculture in many countries. However, little is known about its danger to human health or its physiologic and biochemical pathways. Our study examined the effect of GA3 on liver and kidney function and the effect of quercetin on the hepatorenal toxicity induced by GA3 in four groups of male albino rats. For 4 weeks, the control group (CNT) received saline,

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Section: Organ Lesion and Immunoexpression Cntsupporting

confidence: 90%

Gibberellic acid‐induced hepatorenal dysfunction and oxidative stress: Mitigation by quercetin through modulation of antioxidant, anti‐inflammatory, and antiapoptotic activities

Soliman

Gaber

Alsanie

et al. 2022

Journal of Food Biochemistry

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“…Regarding the placenta expression results, ANGPTL8 is mainly synthesized in the liver and adipose tissue, and it is currently difficult to distinguish the contribution of placenta to fetus. It is well known that placenta exerts neural hormonal regulatory functions to the fetus [ 28 , 29 ]; further investigation on placenta-synthesized ANGPTL8 is guaranteed.…”

Section: Discussionmentioning

confidence: 99%

Angiopoietin-Like 8 in Gestational Diabetes Mellitus: Reduced Levels in Third Trimester Maternal Serum and Placenta, Increased Levels in Cord Blood Serum

Yuan

Zhang

Wang

et al. 2022

International Journal of Endocrinology

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Gestational diabetes mellitus (GDM) poses a significant health risk to pregnant women, and thus exploring the potential underlying mechanism is highly desirable. The aim of the study was to compare maternal serum, cord blood serum, and placental angiopoietin-like 8 (ANGPTL8) levels in the third trimester of pregnancy in women with and without gestational diabetes and explore the potential underlying mechanism. A total of 42 pregnant women (23 with GDM and 19 with normal glucose tolerance (NGT)) along with 29 age-matched non-pregnant healthy females were enrolled. All pregnant subjects were in the late third trimester. Maternal serum and cord blood serum ANGPTL8 levels were measured with an enzyme-linked immunosorbent assay and the protein levels of ANGPTL8 in placentas were assessed with western blotting. The associations between maternal serum and cord blood serum ANGPTL8 levels and metabolic parameters were investigated with the Spearman correlation analysis. Significantly lower levels of maternal serum and placental ANGPTL8 levels were observed in GDM patients compared to NGT pregnant women, while remarkably higher ANGPTL8 levels were present in the cord blood serum samples. The maternal serum ANGPTL8 level was positively correlated with BMI, total cholesterol, triglycerides, and AUC for OGTT and birthweight. Additionally, the cord blood serum ANGPTL8 level was positively correlated with insulin and the homeostatic model assessment for insulin resistance. Both maternal serum and cord blood serum ANGPTL8 levels seemed to correlate with GDM and has the potential to be used as a biomarker for GDM and birthweight prediction.

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“…The antioxidant property of quercetin prevents the in vivo and in vitro oxidation of biomolecules. Quercetin is known to prevent embryonic malformations in pregnant diabetic mice [72]. Various in vivo studies suggest that quercetin within a range of 15 mg/kg to 100 mg/kg for 14-70 days is potential in the treatment of diabetes [73].…”

Section: Diabetesmentioning

confidence: 99%

Health Benefits of Quercetin in Age-Related Diseases

2022

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Polyphenols are the known group of phytochemicals that essentially consists of phenolic rings. These are the plant product present in varied fruits and vegetables. These secondary metabolites perform a protective function in plants from environmental and biological stress. When consumed as a human diet these are also known to prevent various age-associated diseases. Polyphenols are known to possess antioxidant properties and protect against oxidative stress. The literature survey was carried out using databases such as PubMed, Science direct and Springer. The research articles from last 10–12 years were selected for this review based on its relevancy with the topic. The articles selected was mainly focused on quercetin and its health benefits. The present review highlights the main functions of a flavonoid, quercetin. Quercetin is among the widely occurring polyphenol, found abundantly in nature. It is commonly present in different plant products. Onion is known to have the highest quantity of quercetin. This plant compound is possessed antioxidant properties and is considered to have a protective function against aging. It is known to be present in both free and conjugated forms. Quercetin has anti-oxidative, anti-inflammatory, anti-proliferative, anti-carcinogenic, anti-diabetic, and anti-viral properties. The molecule is lipophilic and can easily cross the BBB (Blood-Brain Barrier) and hence protects from neurodegenerative diseases. Various in vivo and in vitro studies have demonstrated the role of quercetin and here a detailed review of quercetin as a curative agent in neurodegeneration, diabetes, cancer, and inflammation has been carried out. Studies have proved that quercetin plays a crucial role in the prevention of age-related disorders. Quercetin is a potent antioxidant which is currently being used in various pharmaceuticals. Properties of quercetin can be further explored in various other disorders. Nanoformulations and liposomal formulations of quercetin can be made to treat other age associated diseases.

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Quercetin improved histological structure and upregulated adiponectin and adiponectin receptors in the placenta of rats with gestational diabetes mellitus

Cited by 22 publications

References 66 publications

Gibberellic acid‐induced hepatorenal dysfunction and oxidative stress: Mitigation by quercetin through modulation of antioxidant, anti‐inflammatory, and antiapoptotic activities

Gibberellic acid‐induced hepatorenal dysfunction and oxidative stress: Mitigation by quercetin through modulation of antioxidant, anti‐inflammatory, and antiapoptotic activities

Angiopoietin-Like 8 in Gestational Diabetes Mellitus: Reduced Levels in Third Trimester Maternal Serum and Placenta, Increased Levels in Cord Blood Serum

Health Benefits of Quercetin in Age-Related Diseases

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