Quercetin-imprinted monolithic polymer

Petrova, Yu. Yu.; Bulatova, Elena V.; Sevast’yanova, Ekaterina V.; Mateyshina, Yulia G.

doi:10.1016/j.matpr.2020.06.213

Cited by 6 publications

(4 citation statements)

References 11 publications

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“…Table 4 compares the performance on the adsorption kinetics and isotherms of the MIP as a selective adsorbent for quercetin in our work with other quercetin-MIPs that previously reported by different methods in the literatures [ 30 , 32 , 48 , 49 , 50 ]. Apparently, the comparison studies revealed that MIP we prepared was excellent in terms of high adsorption capacity, short adsorption time, and fast adsorption kinetics.…”

Section: Resultsmentioning

confidence: 96%

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Selective Adsorption of Quercetin by the Sol-Gel Surface Molecularly Imprinted Polymer

Zhi

Luo

et al. 2023

Polymers

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Quercetin, as one of the most biologically active natural flavonoids, is widely found in various vegetables, fruits and Chinese herbs. In this work, molecularly imprinted polymer (MIP) was synthesized through surface molecular imprinting technology with sol-gel polymerization mechanism on SiO2 at room temperature using quercetin as the template, SiO2 as the supporter, 3-aminopropyltriethoxysilane (APTES) as the functional monomer, and tetraethoxysilane (TEOS) as the cross-linker. The prepared MIP was characterized via scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FT-IR) and nitrogen adsorption measurements to validate its surface morphology, structure and functionality. SEM images revealed that the morphology of MIP was rough and spherical with the particle size of 260 nm larger than that of the support SiO2. In the FTIR spectra of MIP, the band around 1499 cm−1 and 2932 cm−1 were assigned to N−H and C-H groups, respectively. The results indicated that the imprinted polymer layers were grafted on the surface of SiO2 and the MIP had been successfully prepared. Since the specific surface area and pore volume of MIP were markedly higher than those of NIP and SiO2 and were 52.10 m2 g−1 and 0.150 cm3 g−1, respectively, it was evident that the imprinting process created corresponding imprinted cavities and porosity. The MIP for adsorbing quercetin was evaluated by static adsorption experiment. The results indicated that the adsorption equilibrium could be reached within 90 min and the maximum adsorption capacity was as high as 35.70 mg/g. The mechanism for adsorption kinetics and isotherm of MIP for quercetin was proved to conform the pseudo-second-order kinetics model (R2 = 0.9930) and the Freundlich isotherm model (R2 = 0.9999), respectively, revealing that chemical adsorption and heterogeneous surface with multilayer adsorption dominated. In contrast to non-imprinted polymer (NIP), the MIP demonstrated high selectivity and specific recognition towards quercetin whose selectivity coefficients for quercetin relative to biochanin A were 1.61. Furthermore, the adsorption capacity of MIP can be maintaining above 90% after five regeneration cycles, indicating brilliant reusability and potential application for selective adsorption of quercetin.

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Section: Resultsmentioning

confidence: 96%

“…Several papers have been published regarding the preparation of quercetin-MIPs [ 30 , 31 , 32 ]. It was estimated that our MIP would be an available material for the selective adsorption of quercetin.…”

Section: Introductionmentioning

confidence: 99%

Selective Adsorption of Quercetin by the Sol-Gel Surface Molecularly Imprinted Polymer

Zhi

Luo

et al. 2023

Polymers

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“…It was shown that in the presence of polyethylene glycol (porogen) with an average molecular mass of 10000 Da, the sorption capacity of quercetin by the molecularly-imprinted sample was ~5 µmol/g, the specific surface area was 288.1 m 2 /g, and the imprinting factor was 1.41. It was shown that recovery of quercetin (21-43%) is slightly lower, but the imprinting factor (1.4) is not inferior to that of the similar methods for extracting phenolic compounds [26] and dyes [29] with resorcinol-melamine-formaldehyde and phenol-formaldehyde resins, as well as quercetin with surface-imprinted polymers [30,31]. Modeling of the kinetics and isotherms of quercetin rebinding by the samples, obtained in the presence of polyethylene glycol of different average molecular mass, showed compliance with the pseudo-second-order model and the Freundlich model describing an inhomogeneous surface.…”

Section: Discussionmentioning

confidence: 99%

Hydrophilic molecularly imprinted phenol-amine-formaldehyde resins

Petrova,

Bulatova,

Zelentsov

et al. 2023

Chim.Tech.Acta

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Hydrophilic molecularly imprinted resins (MIR), which are produced using hydrophilic monomers such as phenols, aldehydes, melamine or urea, have recently attracted increasing attention for use in separation and preconcentration. Among their obvious advantages are good sorption capacity, high recovery and selectivity, as well as their reusability in aqueous solutions. In this work we applied the bulk molecular imprinting method to produce quercetin-imprinted phenol-amino-formaldehyde resin. For this purpose, phloroglucinol and melamine solutions were mixed with formaldehyde and then polyethylene glycol and quercetin (Qu) were added to the obtained solution as a porogen and a template, respectively. The mixture was stirred under heating, then left in the thermostat for a continuous time. The optimum ratio of phloroglucinol to melamine was 3:1. The average molecular mass of porogen (Mw) varied between 4000–10000 Da. The obtained MIR were eluted with ethanol-water mixture (4:1, v/v) in the Soxhlet extractor for 36 h to remove the template. The MIR were characterized by FTIR-spectroscopy, laser diffraction spectroscopy and differential thermal analysis. The maximum recovery and sorption capacity of MIR synthesized in the presence of a porogen with Mw 10000 were 47% and 4.7 μmol Qu/g, respectively. The maximum imprinting factor was 1.41. The sorption kinetics of quercetin by a non-imprinted resin (NIR) is best described by a pseudo-second-order model, while MIR has a mixed pseudo-first-second-order mechanism.

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“…Therefore, this way is especially appropriate for the imprinting of biological macromolecules. Petrova et al [19] proposed molecularly imprinted membranes on the surface of silica microparticles, which is an organic monolithic polymer prepared by glutathione and 3-methylacroxypropyltrimethoxy-silane (gamma-Maps) in a thiol-ene cleavage reaction triggered by the heating of azodiisobutanitrile. Quercetin exists as a template.…”

Section: Extraction Of Quercetin From Plant Samples By Molecularly Im...mentioning

confidence: 99%

Advances in Molecular Imprinting Technology for the Extraction and Detection of Quercetin in Plants

Zhou

et al. 2023

Polymers

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Quercetin is a kind of flavonoid compound, which has antioxidative, anti-aging and anti-cancer effects, so it is of great importance to study the efficient extraction and highly sensitive detection of quercetin. Molecular imprinting technology has remarkable selectivity and resistance to complex matrix interference, which is often used for extracting quercetin. The methods of molecular imprinted solid phase extraction, molecularly imprinted microsphere extraction, molecularly imprinted electrochemical sensor recognition and molecularly imprinted composite material extraction of quercetin from plant samples were discussed in detail. This review provides valuable information on efficient and sensitive methods for separating and purifying quercetin in plants. It also provides a technical reference for further investigation of the separation and analysis of active ingredients in natural products.

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Quercetin-imprinted monolithic polymer

Cited by 6 publications

References 11 publications

Selective Adsorption of Quercetin by the Sol-Gel Surface Molecularly Imprinted Polymer

Selective Adsorption of Quercetin by the Sol-Gel Surface Molecularly Imprinted Polymer

Hydrophilic molecularly imprinted phenol-amine-formaldehyde resins

Advances in Molecular Imprinting Technology for the Extraction and Detection of Quercetin in Plants

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