Quercetin Glycosides Improve Motor Performance and Muscle Weight in Adult Mice

Kanzaki, Noriyuki; Takemoto, Daisuke; Ono, Yukiko; Izumo, Takayuki; Shibata, Hiroshi; Ye, Xin; Ingram, Donald K.; Ye, Jianping

doi:10.35248/2155-9600.19.9.760

Cited by 4 publications

(3 citation statements)

References 39 publications

(47 reference statements)

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“…Furthermore, quercetin decreased the 3D-clinorotation-induced expression of atrogin-1 and MuRF-1 via the dephosphorylation of ERK [ 60 ], which is indicative of its efficacy in disuse muscle atrophy. Interestingly, long-term (24 weeks) oral treatment with quercetin glycoside effectively improved motor performance and increased muscle (quadratus femoris, gastrocnemius, tibialis anterior, and soleus) mass during the early stages of aging [ 104 ]. The stimulation of mitochondrial biogenesis by quercetin was also reported in a mouse experiment.…”

Section: Polyphenols In Managing Muscle Atrophy and Muscle Healthmentioning

confidence: 99%

Polyphenols and Their Effects on Muscle Atrophy and Muscle Health

2021

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Skeletal muscle atrophy is the decrease in muscle mass and strength caused by reduced protein synthesis/accelerated protein degradation. Various conditions, such as denervation, disuse, aging, chronic diseases, heart disease, obstructive lung disease, diabetes, renal failure, AIDS, sepsis, cancer, and steroidal medications, can cause muscle atrophy. Mechanistically, inflammation, oxidative stress, and mitochondrial dysfunction are among the major contributors to muscle atrophy, by modulating signaling pathways that regulate muscle homeostasis. To prevent muscle catabolism and enhance muscle anabolism, several natural and synthetic compounds have been investigated. Recently, polyphenols (i.e., natural phytochemicals) have received extensive attention regarding their effect on muscle atrophy because of their potent antioxidant and anti-inflammatory properties. Numerous in vitro and in vivo studies have reported polyphenols as strongly effective bioactive molecules that attenuate muscle atrophy and enhance muscle health. This review describes polyphenols as promising bioactive molecules that impede muscle atrophy induced by various proatrophic factors. The effects of each class/subclass of polyphenolic compounds regarding protection against the muscle disorders induced by various pathological/physiological factors are summarized in tabular form and discussed. Although considerable variations in antiatrophic potencies and mechanisms were observed among structurally diverse polyphenolic compounds, they are vital factors to be considered in muscle atrophy prevention strategies.

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Section: Polyphenols In Managing Muscle Atrophy and Muscle Healthmentioning

confidence: 99%

Polyphenols and Their Effects on Muscle Atrophy and Muscle Health

2021

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“…Apigenin reduced oxidative stress and inhibited hyperactive autophagy and apoptosis, alleviating age-related skeletal muscle atrophy in rats [ 77 , 78 ]. Kanzaki et al [ 79 ] reported that quercetin glycosides increased the wet weights of the quadratus femoris, gastrocnemius, tibialis anterior and soleus muscles in mice. While in the tibialis anterior and soleus muscles of rats, ferulic acid increased the production of mechano-growth factor and the antioxidant enzymes [ 80 ].…”

Section: Discussionmentioning

confidence: 99%

Phytoecdysteroids and Anabolic Effect of Atriplex dimorphostegia: UPLC-PDA-MS/MS Profiling, In Silico and In Vivo Models

Zaghloul

Handousa

Singab

et al. 2023

Plants

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Atriplex dimorphostegia (Saltbush) is an annual halophytic shrub that is widely distributed across various parts of Asia. The current study is the first to report the metabolites profile of the total ethanol extract of the aerial parts of A. dimorphostegia (TEAD), and its anabolic activity together with the isolated 20-hydroxyecdysone (20-HE) in orchidectomized male rats. TEAD was analyzed and standardized utilizing UPLC-PDA-ESI–MS/MS and UPLC-PDA-UV techniques, resulting in tentative identification of fifty compounds including polyphenols, steroids and triterpenoids. In addition, 20-HE was quantified, representing 26.79 μg/mg of the extract. Phytochemical investigation of TEAD resulted in the isolation of 20-HE from the ethyl acetate fraction (EFAD) and was identified by conventional spectroscopic methods of analysis. Furthermore, the anabolic effect of the isolated 20-HE and TEAD was then evaluated using in silico and in vivo models. Molecular docking experiments revealed in vitro selectivity of 20-HE towards estrogen receptors (ERs), specifically ERβ over ERα and androgenic receptor (AR). The anabolic efficacy of TEAD and 20-HE was studied in orchidectomized immature male Wistar rats using the weight of gastrocnemius and soleus muscles. The weights of ventral prostate and seminal vesicles were used as indicators for androgenic activity. Rats administered 20-HE and TEAD showed a significant increase (p = 0.0006 and p < 0.0001) in the net muscle mass compared to the negative control, while the group receiving TEAD showed the highest percentage among all groups at p < 0.0001. Histopathological investigation of skeletal muscle fibers showed normal morphological structures, and the group administered 20-HE showed an increase in cross sectional area of muscle fibers comparable to methandienone and testosterone groups at p > 0.99. A. dimorphostegia exhibited promising anabolic activity with minimal androgenic side effects.

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“…Increased wet weights of a particular group of muscles (quadratus femoris, gastrocnemius, tibialis anterior, and soleus) in the treated mice's muscular morphology demonstrated functional benefits. Hence, the long-term oral administration of QG during the early stages of aging can safely and effectively enhance certain aspects of motor performance and increase muscle mass [172].…”

Section: Antioxidantsmentioning

confidence: 99%

An Integrated Approach to Skeletal Muscle Health in Aging

et al. 2023

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A decline in muscle mass and function represents one of the most problematic changes associated with aging, and has dramatic effects on autonomy and quality of life. Several factors contribute to the inexorable process of sarcopenia, such as mitochondrial and autophagy dysfunction, and the lack of regeneration capacity of satellite cells. The physiologic decline in muscle mass and in motoneuron functionality associated with aging is exacerbated by the sedentary lifestyle that accompanies elderly people. Regular physical activity is beneficial to most people, but the elderly need well-designed and carefully administered training programs that improve muscle mass and, consequently, both functional ability and quality of life. Aging also causes alteration in the gut microbiota composition associated with sarcopenia, and some advances in research have elucidated that interventions via the gut microbiota–muscle axis have the potential to ameliorate the sarcopenic phenotype. Several mechanisms are involved in vitamin D muscle atrophy protection, as demonstrated by the decreased muscular function related to vitamin D deficiency. Malnutrition, chronic inflammation, vitamin deficiencies, and an imbalance in the muscle–gut axis are just a few of the factors that can lead to sarcopenia. Supplementing the diet with antioxidants, polyunsaturated fatty acids, vitamins, probiotics, prebiotics, proteins, kefir, and short-chain fatty acids could be potential nutritional therapies against sarcopenia. Finally, a personalized integrated strategy to counteract sarcopenia and maintain the health of skeletal muscles is suggested in this review.

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Quercetin Glycosides Improve Motor Performance and Muscle Weight in Adult Mice

Cited by 4 publications

References 39 publications

Polyphenols and Their Effects on Muscle Atrophy and Muscle Health

Polyphenols and Their Effects on Muscle Atrophy and Muscle Health

Phytoecdysteroids and Anabolic Effect of Atriplex dimorphostegia: UPLC-PDA-MS/MS Profiling, In Silico and In Vivo Models

An Integrated Approach to Skeletal Muscle Health in Aging

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