Quercetin decreases cardiac hypertrophic mediators and maladaptive coronary arterial remodeling in renovascular hypertensive rats without improving cardiac function

Rocha, Eduardo Vieira da; Falchetti, Francisco; Pernomian, Laena; Mello, Marcela M. Blascke de; Parente, Juliana Montenegro; Nogueira, Renato C.; Gomes, Beatriz Q.; Bertozi, Giuliana; Sanches-Lopes, Jessica M.; Tanus‐Santos, José Eduardo; Castro, Michele M.

doi:10.1007/s00210-022-02349-6

Cited by 4 publications

(2 citation statements)

References 45 publications

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“…Angiotensin II also triggers an inflammatory response and increases the synthesis of collagen types I and III appearing in fibroblast, leading to vascular wall thickening and cardiac hypertrophy [ 4 , 5 ]. Previous studies reported that several chemical compounds such as rosiglitazone (peroxisome proliferator-activated receptor-gamma agonist) [ 30 ], resveratrol [ 31 ], quercetin [ 32 ], and a Chinese herbal formula (Xin-Ji-Er-Kang) [ 33 ] attenuated the cardiac and vascular remodeling in the 2K1C animals. In this study, treatment of GD flower diminished the inflammatory cell infiltration of the cardiac myocyte and partially improved the vascular impairment in the 2K1C group; however, the slightly hypertrophy of the cardiac myocyte and the vascular smooth muscle cell remained.…”

Section: Resultsmentioning

confidence: 99%

Cardiovascular Protective Effect of Garcinia dulcis Flower Acetone Extract in 2-Kidney-1-Clip Hypertensive Rats

Thongsepee,

Martviset,

Himakhun

et al. 2024

Advances in Pharmacological and Pharmaceutical Sciences

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Morelloflavone and camboginol are bioactive compounds purified from Garcinia dulcis (GD), which has anti-inflammatory and antihypertensive properties. The objective of this study was to examine the cardiovascular protective effect of GD flower acetone extract in 2-kidney-1-clip (2K1C) hypertensive rats. Male Wistar rats underwent 2K1C or sham operation (SO) and were housed for 4 weeks. Each group of rats, then, was further divided into 2 subgroups receiving oral administration of either 50 mg/kg BW GD extract or corn oil (vehicle) daily for 4 weeks. Noninvasive blood pressure (BP) and body weight were measured weekly throughout the study. Subsequently, the invasive measurement of arterial BP and the heart rate were determined in all anesthetized rats. The baroreceptor reflex sensitivity (BRS) was investigated by injection of either phenylephrine or sodium nitroprusside for bradycardia or tachycardia response, respectively. Histological examination of the heart and thoracic aorta was also performed in order to investigate the general morphology and the tumor necrosis factor alpha (TNF-α) expression. We found that the GD flower extract significantly diminished the BP and restored the impaired BRS. Moreover, it also decreased the TNF-α expression in the cardiac muscle and thoracic aorta of 2K1C when compared to the SO group. Taken together, our data showed that GD flower extract exhibits the cardiovascular protective effect in the 2K1C hypertensive rats.

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Section: Resultsmentioning

confidence: 99%

Cardiovascular Protective Effect of Garcinia dulcis Flower Acetone Extract in 2-Kidney-1-Clip Hypertensive Rats

Thongsepee,

Martviset,

Himakhun

et al. 2024

Advances in Pharmacological and Pharmaceutical Sciences

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“…Moreover, the authors demonstrated the anti-inflammatory activity of quercetin in rats treated for 60 days with 25 mg quercetin/kg body weight in a condition of a hypercholesterolemic diet [100]. Furthermore, by reducing MMP2 (Matrix Metalloproteinase 2) activity and oxidative stress, chronic treatment with quercetin (10 mg/kg/day) ameliorates hypertension-induced coronary hypertrophic remodeling in renovascular hypertensive rats, even if it does not reduce cardiac dysfunction [101]. An interesting study on patients with stable coronary artery disease demonstrated that quercetin therapy reduces the levels of IL-1b in the blood but also the level of IκBa mRNA, thus affecting the transcriptional activity of NF-κB signaling and finally ameliorating the indicators of chronic systemic inflammation after two-months of quercetin treatment at the daily dose of 120 mg [102].…”

Section: Flavonoids and Cardiovascular Diseases: Role Of Nf-κb Signal...mentioning

confidence: 97%

Effects of Flavonoids on Cancer, Cardiovascular and Neurodegenerative Diseases: Role of NF-κB Signaling Pathway

Barreca

Alessandro

Corrado

2023

IJMS

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Flavonoids are polyphenolic phytochemical compounds found in many plants, fruits, vegetables, and leaves. They have a multitude of medicinal applications due to their anti-inflammatory, antioxidative, antiviral, and anticarcinogenic properties. Furthermore, they also have neuroprotective and cardioprotective effects. Their biological properties depend on the chemical structure of flavonoids, their mechanism of action, and their bioavailability. The beneficial effects of flavonoids have been proven for a variety of diseases. In the last few years, it is demonstrated that the effects of flavonoids are mediated by inhibiting the NF-κB (Nuclear Factor-κB) pathway. In this review, we have summarized the effects of some flavonoids on the most common diseases, such as cancer, cardiovascular, and human neurodegenerative diseases. Here, we collected all recent studies describing the protective and prevention role of flavonoids derived from plants by specifically focusing their action on the NF-κB signaling pathway.

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Preliminary Exploration of Potential Active Ingredients and Molecular Mechanisms of Yanggan Yishui Granules for Treating Hypertensive Nephropathy Using UPLC-Q-TOF/MS Coupled with Network Pharmacology and Molecular Docking Strategy

Yang,

Zhang,

Dai

et al. 2024

Journal of Analytical Methods in Chemistry

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Hypertensive nephropathy (HN) is a prevalent complication of hypertension and stands as the second primary reason for end-stage renal disease. Research in clinical settings has revealed that Yanggan Yishui Granule (YGYSG) has significant therapeutic effects on HN. However, the material basis and action mechanisms of YGYSG against HN remain unclear. Consequently, this study utilized a comprehensive method integrating ultraperformance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS), network pharmacology, and molecular docking to delineate the active ingredients and potential therapeutic mechanisms of YGYSG for treating HN. Firstly, sixty distinct components were recognized in total as potential active ingredients in YGYSG by UPLC-Q-TOF/MS. Subsequently, the mechanisms of YGYSG against HN were revealed for the first time using network pharmacology. 23 ingredients played key roles in the complete network and were the key active ingredients, which could affect the renin-angiotensin system, fluid shear stress and atherosclerosis, HIF-1 signaling pathway, and AGE-RAGE signaling pathway in diabetic complications by regulating 29 key targets such as TNF, IL6, ALB, EGFR, ACE, and MMP2. YGYSG could treat HN through the suppression of inflammatory response and oxidative stress, attenuating the proliferation of renal vascular smooth muscle cells, lessening glomerular capillary systolic pressure, and ameliorating renal dysfunction and vascular damage through the aforementioned targets and pathways. Molecular docking results revealed that most key active ingredients exhibited a high affinity for binding to the key targets. This study pioneers in clarifying the bioactive compounds and molecular mechanisms of YGYSG against HN and offers scientific reference into the clinical application.

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Quercetin decreases cardiac hypertrophic mediators and maladaptive coronary arterial remodeling in renovascular hypertensive rats without improving cardiac function

Cited by 4 publications

References 45 publications

Cardiovascular Protective Effect of Garcinia dulcis Flower Acetone Extract in 2-Kidney-1-Clip Hypertensive Rats

Cardiovascular Protective Effect of Garcinia dulcis Flower Acetone Extract in 2-Kidney-1-Clip Hypertensive Rats

Effects of Flavonoids on Cancer, Cardiovascular and Neurodegenerative Diseases: Role of NF-κB Signaling Pathway

Preliminary Exploration of Potential Active Ingredients and Molecular Mechanisms of Yanggan Yishui Granules for Treating Hypertensive Nephropathy Using UPLC-Q-TOF/MS Coupled with Network Pharmacology and Molecular Docking Strategy

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