Quercetin attenuates adipose hypertrophy, in part through activation of adipogenesis in rats fed a high-fat diet

Perdicaro, Diahann J.; Lanzi, Cecilia Rodríguez; Tudela, Julián Gambarte; Miatello, Roberto; Oteiza, Patricia I.; Prieto, Marcela A. Vazquez

doi:10.1016/j.jnutbio.2020.108352

Cited by 33 publications

(14 citation statements)

References 30 publications

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“…On the other side Perdicaro et al demonstrated that quercetin attenuated adipose tissue hypertrophy, reduced the adipocyte size but activated the adipogenesis in HFD-fed rats. Quercetin supplemented rats showed increased levels of angiogenic ( Vascular endothelial growth factor 1 and 2 (Vegf1, Vegf2 ) and adipogenic ( Pparg and C/ebpa ) markers but also mitigated inflammation, and reticulum stress [ 273 ].…”

Section: Flavonolsmentioning

confidence: 99%

Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

et al. 2020

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The prevention and treatment of obesity is primary based on the follow-up of a healthy lifestyle, which includes a healthy diet with an important presence of bioactive compounds such as polyphenols. For many years, the health benefits of polyphenols have been attributed to their anti-oxidant capacity as free radical scavengers. More recently it has been described that polyphenols activate other cell-signaling pathways that are not related to ROS production but rather involved in metabolic regulation. In this review, we have summarized the current knowledge in this field by focusing on the metabolic effects of flavonoids. Flavonoids are widely distributed in the plant kingdom where they are used for growing and defensing. They are structurally characterized by two benzene rings and a heterocyclic pyrone ring and based on the oxidation and saturation status of the heterocyclic ring flavonoids are grouped in seven different subclasses. The present work is focused on describing the molecular mechanisms underlying the metabolic impact of flavonoids in obesity and obesity-related diseases. We described the effects of each group of flavonoids in liver, white and brown adipose tissue and central nervous system and the metabolic and signaling pathways involved on them.

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Section: Flavonolsmentioning

confidence: 99%

Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

et al. 2020

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“…Recent study has shown that quercetin significantly attenuated systemic IR and inflammation in HFD‐fed rats (Perdicaro et al, 2020). Quercetin attenuated the expansion of adipose tissue in WAT and reduced serum IL‐6 and MCP‐1 mRNA levels in HFD‐induced obese mice (Forney, Lenard, Stewart, & Henagan, 2018).…”

Section: Antifatty Hepatitis Property Of Quercetinmentioning

confidence: 99%

Quercetin as a protective agent for liver diseases: A comprehensive descriptive review of the molecular mechanism

Zhao

Wang

Deng

et al. 2021

Phytotherapy Research

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Quercetin is the major representative of the flavonoid subgroup of flavones, with good pharmacological activities for the treatment of liver diseases, including liver steatosis, fatty hepatitis, liver fibrosis, and liver cancer. It can significantly influence the development of liver diseases via multiple targets and multiple pathways via antifat accumulation, anti‐inflammatory, and antioxidant activity, as well as the inhibition of cellular apoptosis and proliferation. Despite extensive research on understanding the mechanism of quercetin in the treatment of liver diseases, there are still no targeted therapies available. Thus, we have comprehensively searched and summarized the different targets of quercetin in different stages of liver diseases and concluded that quercetin inhibited inflammation of the liver mainly through NF‐κB/TLR/NLRP3, reduced PI3K/Nrf2‐mediated oxidative stress, mTOR activation in autophagy, and inhibited the expression of apoptotic factors associated with the development of liver diseases. In addition, quercetin showed different mechanisms of action at different stages of liver diseases, including the regulation of PPAR, UCP, and PLIN2‐related factors via brown fat activation in liver steatosis. The compound inhibited stromal ECM deposition at the liver fibrosis stage, affecting TGF1β, endoplasmic reticulum stress (ERs), and apoptosis. While at the final liver cancer stage, inhibiting cancer cell proliferation and spread via the hTERT, MEK1/ERK1/2, Notch, and Wnt/β‐catenin‐related signaling pathways. In conclusion, quercetin is an effective liver protectant. We hope to explore the pathogenesis of quercetin in different stages of liver diseases through the review, so as to provide more accurate targets and theoretical basis for further research of quercetin in the treatment of liver diseases.

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“…In addition, they also inhibited osteoclast differentiation by decreasing reactive oxygen species or osteoclast activity by decreasing inflammatory cytokine levels [37,38]. Epicatechin, rutin, isoquercitrin, and quercetin are involved in lipid or energy metabolism through SREBP/AMPK signaling or the fat oxidation pathway [39][40][41]. It has been reported that rutin (quercetin-3-O-β-rutinoside) and isoquercitrin (quercetin-3-O-βglucoside) are modified glycoside forms of quercetin, known as phytoestrogen, but have different bioavailability in vivo [42].…”

Section: Phytochemical Profiling Of Eeatmentioning

confidence: 99%

Ethanol Extract of Amomum tsao-ko Ameliorates Ovariectomy-Induced Trabecular Loss and Fat Accumulation

et al. 2021

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In Asia, Amomum tsao-ko has long been used as a spice or seasoning in food to stimulate digestion. In the present study, we evaluated the effects of ethanol extract of Amomum tsao-ko (EEAT) on menopausal osteoporosis and obesity. After the administration of EEAT in ovariectomy (OVX) mice models for five weeks, microcomputed tomography and a histological analysis were performed to assess, respectively, the trabecular structure and the fat accumulation in adipose, liver, and bone tissues. We also examined the effects of EEAT on a bone marrow macrophage model of osteoclastogenesis by in vitro stimulation from the receptor activator of nuclear factor-kappa Β ligand (RANKL) through real-time PCR and Western blot analysis. In addition, ultrahigh performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) with authentic standards was applied to characterize the phytochemical profiling of EEAT. We found that EEAT significantly decreased OVX-induced body weight gain and fat accumulation, significantly prevented OVX-induced deterioration of bone mineral density and microstructure of trabecular tissues, and significantly inhibited osteoclast differentiation by downregulating NF-κB/Fos/NFATc1 signaling in osteoclasts. Furthermore, UHPLC–MS/MS identified eight beneficial phytochemicals in EEAT. Collectively, these results suggest that EEAT might be an effective nutraceutical candidate to attenuate menopausal osteoporosis by inhibiting osteoclastogenesis and to prevent obesity by suppressing fat accumulation.

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Quercetin attenuates adipose hypertrophy, in part through activation of adipogenesis in rats fed a high-fat diet

Cited by 33 publications

References 30 publications

Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

Quercetin as a protective agent for liver diseases: A comprehensive descriptive review of the molecular mechanism

Ethanol Extract of Amomum tsao-ko Ameliorates Ovariectomy-Induced Trabecular Loss and Fat Accumulation

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