Quercetin and ovarian cancer: An evaluation based on a systematic review

Abstract

Some studies have suggested chemopreventive and therapeutic effects of quercetin (Q) on carcinogenesis. The aim of this review was to evaluate the association between Q and ovarian cancer risk among human researches and induced sensitivity to some types of chemotherapeutic drugs and antiproliferative effects of this flavonoid in the animals and cell lines studies. Data for this systematic review were achieved through searches of the MEDLINE (PubMed), Google Scholar, Science Direct, Scopus, Cochrane, SID, and Magiran databases for studies published up to May 2015. Relevant studies were reviewed based on Preferred Reporting Item for Systematic Review and Meta analysis guidelines. From the total number of 220 papers obtained at the initial search, 13 publications including 1 prospective, 2 case -control, 1 animal, and 9 in vitro human and animal cancer cell lines studies were eligible. Despite findings in laboratory settings, results from the epidemiological studies commented that the potentially protective effects of Q not be able to significantly decrease ovarian cancer risk at levels commonly consumed (1.01–31.7 mg/day) in a typical diet. However, animal and in vitro studies suggest that Q exerts anticancer effects via inhibiting tumor growth, and angiogenesis, interrupt the cell cycle, and induce apoptosis. It is highlighted the need for more studies to be conducted.

Network Pharmacology-Based and Clinically Relevant Prediction of the Potential Targets of Chinese Herbs in Ovarian Cancer Patients

“…Among the 189 kinds of components, stigmasterol, β -sitosterol, cetoside, quercetin, oleanolic acid, apigenin, paeoniflorin, artemisinin, and kaempferol, appear more frequently. Quercetin [ 31 , 32 ], stigmasterol [ 33 , 34 ], and oleanolic acid [ 35 , 36 ] have been documented to have antitumor effects.…”

Basic Studies on Chemopreventive Properties of Quercetin and Curcumin and Other Plant-origin Compounds in Ovarian Cancer Cells – A Mini-review

“…Up to date several dietary, clinical (cohort and case-control) studies evaluating the association of some flavonoids (mostly nonisoflavones) and its subgroup components consumption and ovarian cancer risk were already performed (Mohammadi et al [32], Parvaresh et al [33], Hua et al [6]). According to the researchers, there has been no association between ovarian cancer risk and total nonisoflavone flavonoids intake [32].…”

“…Although there have been published some reviews summarizing knowledge in this subject [31][32][33][34], in this paper we have presented more precise of dose-dependent in vitro, in vivo aspects of action of above mentioned plant origin bio-active compounds in relation to platinum-based cytostatics towards ovarian cancer.…”

Telomerase Inhibitors from Natural Products and Their Anticancer Potential

“…In addition, several animal studies have also been conducted and they found the mechanisms of chemopreventive and therapeutic effects of quercetin [ 175 , 176 , 177 , 178 ]. The epidemiological studies also reported that the regular consumption of quercetin (1.01–31.7 mg/day) could reduce the ovarian cancer risk [ 179 ]. Furthermore, in vivo and in vitro studies suggested that quercetin exerts anti-carcinogenic potential through inhibiting angiogenesis and tumor growth, cell cycle arrest, and inducing apoptosis [ 180 , 181 ].…”