Quercetin and naringenin abate diethylnitrosamine/acetylaminofluorene-induced hepatocarcinogenesis in Wistar rats: the roles of oxidative stress, inflammation and cell apoptosis

Ahmed, Osama M.; Ahmed, A. A.; Fahim, Hanaa I.; Zaky, Mohamed Y.

doi:10.1080/01480545.2019.1683187

Cited by 47 publications

(31 citation statements)

References 72 publications

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“…Quercetin and naringenin prevented the lowered mRNA expression of liver IL-4, p53 and Bcl-2 in a diethylnitrosamine/2-acetylaminofluorene-induced hepatocarcinogenesis model in rats [151]. Naringenin inhibited the migration of breast cancer MDA-MR-231 cell line via modulation of Quercetin and naringenin prevented the lowered mRNA expression of liver IL-4, p53 and Bcl-2 in a diethylnitrosamine/2-acetylaminofluorene-induced hepatocarcinogenesis model in rats [151]. Naringenin inhibited the migration of breast cancer MDA-MR-231 cell line via modulation of inflammatory and apoptotic signaling pathways [152].…”

Section: Immunomodulatory and Anti-inflammatory Effects Of Flavonoidsmentioning

confidence: 93%

“…Hesperetin inhibited cell proliferation markers, angiogenic growth factors, COX-2 mRNA expression in 1,2dimethylhydrazine-induced colon cancer [150]. Quercetin and naringenin prevented the lowered mRNA expression of liver IL-4, p53 and Bcl-2 in a diethylnitrosamine/2-acetylaminofluorene-induced hepatocarcinogenesis model in rats [151]. Naringenin inhibited the migration of breast cancer MDA-MR-231 cell line via modulation of Quercetin and naringenin prevented the lowered mRNA expression of liver IL-4, p53 and Bcl-2 in a diethylnitrosamine/2-acetylaminofluorene-induced hepatocarcinogenesis model in rats [151].…”

Section: Immunomodulatory and Anti-inflammatory Effects Of Flavonoidsmentioning

confidence: 95%

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Flavonoids as Anticancer Agents

et al. 2020

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Flavonoids are polyphenolic compounds subdivided into 6 groups: isoflavonoids, flavanones, flavanols, flavonols, flavones and anthocyanidins found in a variety of plants. Fruits, vegetables, plant-derived beverages such as green tea, wine and cocoa-based products are the main dietary sources of flavonoids. Flavonoids have been shown to possess a wide variety of anticancer effects: they modulate reactive oxygen species (ROS)-scavenging enzyme activities, participate in arresting the cell cycle, induce apoptosis, autophagy, and suppress cancer cell proliferation and invasiveness. Flavonoids have dual action regarding ROS homeostasis—they act as antioxidants under normal conditions and are potent pro-oxidants in cancer cells triggering the apoptotic pathways and downregulating pro-inflammatory signaling pathways. This article reviews the biochemical properties and bioavailability of flavonoids, their anticancer activity and its mechanisms of action.

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Section: Immunomodulatory and Anti-inflammatory Effects Of Flavonoidsmentioning

confidence: 93%

Section: Immunomodulatory and Anti-inflammatory Effects Of Flavonoidsmentioning

confidence: 95%

Flavonoids as Anticancer Agents

et al. 2020

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“…[36]. It is a glycone of rutin, and it is a parent compound of a number of various flavonoids [37,38]. Although the antidiabetic effects of hesperidin and quercetin were reported by some publications, the mechanisms of their antidiabetic actions are not fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic Potency, Antioxidant Effects, and Mode of Actions ofCitrus reticulataFruit Peel Hydroethanolic Extract, Hesperidin, and Quercetin in Nicotinamide/Streptozotocin-Induced Wistar Diabetic Rats

Ali

Abdel‐Gabbar

Abdel-Twab

et al. 2020

Oxidative Medicine and Cellular Longevity

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This study is aimed at assessing the antihyperglycemic, antihyperlipidemic, and antioxidant effects of Citrus reticulata (C. reticulata) fruit peel hydroethanolic extract and two flavonoids, hesperidin and quercetin, in nicotinamide (NA)/streptozotocin- (STZ-) induced type 2 diabetic rats. In addition, GC-MS and HPLC-MS analyses of the extract were performed and the results indicated the presence of multiple flavonoids including hesperidin, quercetin, naringin, and polymethoxylated flavones (nobiletin and tangeretin). To achieve the aim of the study, diabetic rats with NA/STZ-induced T2DM were orally treated with C. reticulata fruit peel hydroethanolic extract, hesperidin, and quercetin at a dose of 100 mg/kg b.w./day for four weeks. The treatments with C. reticulata fruit peel extract, hesperidin, and quercetin significantly ameliorated the impaired oral glucose tolerance; the elevated serum fructosamine level; the diminished serum insulin and C-peptide levels; the altered HOMA-IR, HOMA-IS, and HOMA-β cell function; the decreased liver glycogen content; the increased liver glucose-6-phosphatase and glycogen phosphorylase activities; the deleteriously affected serum lipid profile; the elevated serum AST and ALT activities; and the raised serum creatinine and urea levels in the diabetic rats. The treatments also produced remarkable improvement in the antioxidant defense system manifested by a decrease in the elevated liver lipid peroxidation and an increase in the lowered glutathione content and GPx, GST, and SOD activities. Furthermore, the three treatments enhanced the mRNA expression of GLUT-4 and the insulin receptor β-subunit, but only quercetin produced a significant increase in the expression of adiponectin in adipose tissue of diabetic rats. In conclusion, C. reticulata fruit peel hydroethanolic extract, hesperidin, and quercetin have potent antidiabetic effects which may be mediated through their insulinotropic effects and insulin-sensitizing actions. In addition, the alleviation of the antioxidant defense system by the extract, hesperidin, and naringin may have an important action to enhance the antidiabetic actions and to improve liver and kidney functions in NA/STZ-induced diabetic rats.

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“…Ahmed et al employed the DEN/2-acetylaminofluorene (2AAF) rat HCC model to investigate the anti-cancer activity of NIN in vivo and found that NIN treatment significantly abated hepatocarcinogenesis by decreasing hepatic NO levels and lipid peroxidation, upregulating SOD, GPx and CAT, and increasing intrahepatic GSH content. NIN (10 mg/ kg) treatment also significantly promoted expressions of anti-inflammatory cytokines IL-4, and tumor suppressor P53 in livers of these rats [96]. Most recently, it has been reported that 6-C-(E-phenylethenyl) NIN (6-CEPN), a novel seminatural derivative of NIN, inhibits HCC tumor growth and enhances the sensitivity of HCC cells to therapeutic drugs, including cisplatin, 5-fluorouracil, and sorafenib.…”

Section: The Effect Of Nin On Hepatic Carcinomamentioning

confidence: 91%

Flavonoids from Aurantii Fructus Immaturus and Aurantii Fructus: promising phytomedicines for the treatment of liver diseases

Huang

2020

Chin Med

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Background: Liver diseases and related complications are major sources of morbidity and mortality, which places a huge financial burden on patients and lead to nonnegligible social problems. Therefore, the discovery of novel therapeutic drugs for the treatment of liver diseases is urgently required. Aurantii Fructus Immaturus (AFI) and Aurantii Fructus (AF) are frequently used herbal medicines in traditional Chinese medicine (TCM) formulas for the treatment of diverse ailments. A variety of bioactive ingredients have been isolated and identified from AFI and AF, including alkaloids, flavonoids, coumarins and volatile oils. Main body: Emerging evidence suggests that flavonoids, especially hesperidin (HD), naringenin (NIN), nobiletin (NOB), naringin (NRG), tangeretin (TN), hesperetin (HT) and eriodictyol (ED) are major representative bioactive ingredients that alleviate diseases through multi-targeting mechanisms, including anti-oxidative stress, anti-cytotoxicity, anti-inflammation, anti-fibrosis and anti-tumor mechanisms. In the current review, we summarize the recent progress in the research of hepatoprotective effects of HD, NIN, NOB, NRG, TN, HT and ED and highlight the potential underlying molecular mechanisms. We also point out the limitations of the current studies and shed light on further in-depth pharmacological and pharmacokinetic studies of these bioactive flavonoids. Conclusion: This review outlines the recent advances in the literature and highlights the potential of these flavonoids isolated from AFI and AF as therapeutic agents for the treatment of liver diseases. Further pharmacological studies will accelerate the development of natural products in AFI and AF and their derivatives as medicines with tantalizing prospects in the clinical application.

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Quercetin and naringenin abate diethylnitrosamine/acetylaminofluorene-induced hepatocarcinogenesis in Wistar rats: the roles of oxidative stress, inflammation and cell apoptosis

Cited by 47 publications

References 72 publications

Flavonoids as Anticancer Agents

Flavonoids as Anticancer Agents

Antidiabetic Potency, Antioxidant Effects, and Mode of Actions ofCitrus reticulataFruit Peel Hydroethanolic Extract, Hesperidin, and Quercetin in Nicotinamide/Streptozotocin-Induced Wistar Diabetic Rats

Flavonoids from Aurantii Fructus Immaturus and Aurantii Fructus: promising phytomedicines for the treatment of liver diseases

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