Quercetin and HSC70 coregulate the anti-inflammatory action of the ubiquitin-like protein MNSFβ

Nakamura, Morihiko; Fukuma, Yuki; Notsu, Kaori; Kono, Megumi

doi:10.1007/s11033-021-06949-y

Cited by 7 publications

(3 citation statements)

References 37 publications

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“…A recent study demonstrated the effect of quercetin in regulating monoclonal nonspecific suppressor factor β on tumor necrosis factor- α secretion in lipopolysaccharide-stimulated macrophages. [ 88 ] In this study, quercetin and the heat shock protein HSC70 together modulated the role of monoclonal nonspecific inhibitors β . In the macrophage-like cell line RAW264.7, quercetin dose-dependent inhibition of LPS/interferon γ -induced nitric oxide production without cytotoxicity.…”

Section: Anti-inflammatory Activitymentioning

confidence: 88%

Pharmacological Activity of Quercetin: An Updated Review

Wang

Yao

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Quercetin, a natural flavonoid compound with a widespread occurrence throughout the plant kingdom, exhibits a variety of pharmacological activities. Because of the wide spectrum of health-promoting effects, quercetin has attracted much attention of dietitians and medicinal chemists. An updated review of the literature on quercetin was performed using PubMed, Embase, and Science Direct databases. This article presents an overview of recent developments in pharmacological activities of quercetin including anti-SARS-CoV-2, antioxidant, anticancer, antiaging, antiviral, and anti-inflammatory activities as well as the mechanism of actions involved. The biological activities of quercetin were evaluated both in vitro and in vivo, involving a number of cell lines and animal models, but metabolic mechanisms of quercetin in the human body are not clear. Therefore, further large sample clinical studies are needed to determine the appropriate dosage and form of quercetin for the treatment of the disease.

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Section: Anti-inflammatory Activitymentioning

confidence: 88%

Pharmacological Activity of Quercetin: An Updated Review

Wang

Yao

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Furthermore, in Martynia annua and Tephrosia purpurea [64], quercetin was found to have antioxidant activity. Also, quercetin has protection against endotoxin-induced inflammatory response [65], surgical-induced osteoarthritis [66], LPSinduced oxidative stress and inflammation [67], LPS/interferon c-induced nitric oxide production [68], TNF-α induced inflammation [69], and CCl4-induced inflammation [70].…”

Section: Skin Sensitivitymentioning

confidence: 99%

Quercetin: A Potential Polydynamic Drug

Georgiou,

Kakava,

Routsi

et al. 2023

Molecules

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The study of natural products as potential drug leads has gained tremendous research interest. Quercetin is one of those natural products. It belongs to the family of flavonoids and, more specifically, flavonols. This review summarizes the beneficial pharmaceutical effects of quercetin, such as its anti-cancer, anti-inflammatory, and antimicrobial properties, which are some of the quercetin effects described in this review. Nevertheless, quercetin shows poor bioavailability and low solubility. For this reason, its encapsulation in macromolecules increases its bioavailability and therefore pharmaceutical efficiency. In this review, a brief description of the different forms of encapsulation of quercetin are described, and new ones are proposed. The beneficial effects of applying new pharmaceutical forms of nanotechnology are outlined.

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“…2 ). In addition, the contribution of heat shock proteins to the regulation of Bcl-G stability should be considered as it was demonstrated that siRNA-mediated downregulation of Hsc70 was associated with a substantial decrease in the level of Bcl-G protein in mouse macrophages [ 57 ].…”

Section: Regulation Of Bcl-g Level and Activitymentioning

confidence: 99%

BCL-G: 20 years of research on a non-typical protein from the BCL-2 family

Hartman

Czyż

2023

Cell Death Differ

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Proteins from the BCL-2 family control cell survival and apoptosis in health and disease, and regulate apoptosis-unrelated cellular processes. BCL-Gonad (BCL-G, also known as BCL2-like 14) is a non-typical protein of the family as its long isoform (BCL-GL) consists of BH2 and BH3 domains without the BH1 motif. BCL-G is predominantly expressed in normal testes and different organs of the gastrointestinal tract. The complexity of regulatory mechanisms of BCL-G expression and post-translational modifications suggests that BCL-G may play distinct roles in different types of cells and disorders. While several genetic alterations of BCL2L14 have been reported, gene deletions and amplifications prevail, which is also confirmed by the analysis of sequencing data for different types of cancer. Although the studies validating the phenotypic consequences of genetic manipulations of BCL-G are limited, the role of BCL-G in apoptosis has been undermined. Recent studies using gene-perturbation approaches have revealed apoptosis-unrelated functions of BCL-G in intracellular trafficking, immunomodulation, and regulation of the mucin scaffolding network. These studies were, however, limited mainly to the role of BCL-G in the gastrointestinal tract. Therefore, further efforts using state-of-the-art methods and various types of cells are required to find out more about BCL-G activities. Deciphering the isoform-specific functions of BCL-G and the BCL-G interactome may result in the designing of novel therapeutic approaches, in which BCL-G activity will be either imitated using small-molecule BH3 mimetics or inhibited to counteract BCL-G upregulation. This review summarizes two decades of research on BCL-G.

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Quercetin and HSC70 coregulate the anti-inflammatory action of the ubiquitin-like protein MNSFβ

Cited by 7 publications

References 37 publications

Pharmacological Activity of Quercetin: An Updated Review

Pharmacological Activity of Quercetin: An Updated Review

Quercetin: A Potential Polydynamic Drug

BCL-G: 20 years of research on a non-typical protein from the BCL-2 family

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