Quercetin Ameliorates Insulin Resistance Concomitant Early Cardiovascular Changes in Experimental Rats

Abstract

Quercetin is a dietary flavonoid found in a wide range of fruits and vegetables; it has diverse biological activities, possesses beneficial effects in ameliorating diabetic complications, apart from the effect of quercetin on fructose feed induced insulin resistance (IR) linked cardiac dysfunction have not been entirely revealed. This study aspires to explore the effect of quercetin on metabolism, oxidative stress, cardiomyocytes damage and cardiac function in IR state. Wistar rats either sex weighing 220-250 g (n = 8), were divided into four groups, kept on either control diet and high fructose diet and supplement with a quercetin as a test drug and metformin as a standard, at the dose of 50 and 200 mg/kg; p.o., respectively. Daily measured body weight, feed, and water intake for 35 days, Oral glucose tolerance test (OGTT) performed in animals on the 32 nd day. At end of the study (36 th day), measured hemodynamic parameters after that estimation of various biochemical parameters. Finally, the animals were sacrificed for isolation of tissues and measured heart weight, the oxidative stress level of heart and histopathological changes. Treatment of quercetin with fructose-fed ameliorated all the parameters revile by the contrast of IR rats. The outcome of quercetin associated improves insulin sensitivity, normalized lipid profile, abolish hemodynamic changes, oxidative stress and cardiac injury markers within fructose-fed, and lesser histopathological changes were observed in contrast with IR rats. These beneficial effects of quercetin mediated by improving insulin sensitivity and metabolism; reduced oxidative stress could potentially be used to ameliorate the myocardial damage.