Quercetin ameliorates imiquimod-induced psoriasis-like skin inflammation in mice via the NF-κB pathway

Chen, Haiming; Lu, Chuanjian; Liu, Huazhen; Wang, Maojie; Zhao, Hui; Yan, Yaohua; Han, Ling

doi:10.1016/j.intimp.2017.04.022

Cited by 119 publications

(71 citation statements)

References 53 publications

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“…Topical application of 5% IMQ cream to mice can induce psoriasis‐like dermatitis with increased natural immune response and subsequent inflammatory cytokines, which mimic pathophysiology of human psoriasis (but not 100%). Hence, IMQ‐induced psoriasis in mice model is accepted as a better model for exploring the anti‐psoriasis property of any agent or drug (Chen et al, ; Li et al, ). Therefore, for this present experiment, IMQ‐induced psoriasis model were induced in BALB/c mice model as they are highly susceptible to immune modulation (Tao & Reese, ).…”

Section: Discussionmentioning

confidence: 99%

“…The possible cytokines inhibitory activity of GRg1 (50 mg) in the IMQ induced psoriasis mice model could be due to immunomodulatory and anti‐inflammatory properties. Nonetheless, the exact mechanism is unknown, but previously many studies have hinted that those above‐mentioned inflammatory mediators (cytokines) are regulated via NF‐κB signaling pathway (Chen et al, ; Li et al, ; Zhang et al, ). Hence, we would like to explore whether GRg1 exhibit anti‐inflammatory activity via regulating the NF‐κB signaling pathway.…”

Section: Discussionmentioning

confidence: 99%

“…Totally 50 healthy BALB/c mice were randomly divided into five groups with t10 mice in each group ( n = 10). Psoriasis‐like dermatitis skin lesion was induced by daily topical application of 5% IMQ (62.5 mg) cream on the shaved back (3 × 4 cm) and right ear (2 × 2 cm) for 7 consecutive days (Chen et al, ). The control and GRg1 alone group mice received either water or GRg1 (50 mg/kg; orally) for 14 days without any IMQ induction, whereas the treatment group mice received either GRg1 (50 mg/kg; orally) or DXM (10 mg/kg; orally) for 7 days before and together with IMQ induction for another 7 days (totally 14 days of treatment).…”

Section: Methodsmentioning

confidence: 99%

“…Remaining skin was homogenized with Tris HCl buffer solution (pH 7.4) and centrifuged (10,000 rpm at 4°C for 15 min) and the supernatant was used for biochemical and molecular analysis. The PASI score (0–4) including the skin erythema and scaling were measured (lesioned area) to monitor the grade of psoriasis severity on the eighth day based on scoring range from 0 to 4, where 0 represents none, 1 represents slight, 2 represents moderate, 3 represents marked/high, and 4 represents very marked/very high (Chen et al, ). Also, the skin and right ear thickness were determined (index of inflammation) on eighth day using thickness gauge/caliper bought from Guanglu Digital Caliper Manufacturer Co., Ltd. (Beijing, China).…”

Section: Methodsmentioning

confidence: 99%

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Ginsenoside Rg1 abolish imiquimod‐induced psoriasis‐like dermatitis in BALB/c mice via downregulating NF‐κB signaling pathway

Shi

Chen

et al. 2019

J Food Biochem

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This animal experiment was framed to evaluate the beneficial effect of ginsenoside Rg1 (GRg1) against imiquimod (IMQ)‐induced psoriasis‐like dermatitis model to reveal the underpinning mechanism. Fifty healthy BALB/c mice were divided into five groups as control, GRg1, IMQ induced, oral treatment of GRg1 (50 mg/kg), or dexamethasone (DXM; 10 mg/kg) in IMQ‐induced mice. Treatment with GRg1 or DXM significantly mitigates (p < .01) psoriasis area severity index (PASI) score, skin thickness, lipid peroxidation, and inflammatory markers (IL‐23, 22, 17A, 1β, and TNF‐α). Moreover, administration of GRg1 or DXM considerably reversed the morphological changes induced by IMQ with improved (p < .01) antioxidant activity (SOD, CAT). In addition, a marked downregulation (p < .01) of protein expressions of pIκB and NF‐κB p65 (NF‐κB signaling pathway) were noted in GRg1 group. Collectively, GRg1 or DXM treatment significantly abolishes IMQ‐induced psoriasis‐like dermatitis by lowering PASI score, inflammation through downregulating NF‐κB signaling pathway. Practical applications This is the very first study to explore the efficacy of ginsenoside Rg1 (GRg1) against IMQ‐induced psoriasis in the mice model to reveal the underpinning mechanism. The results clearly showed that GRg1 potent anti‐psoriasis activity by lowering PASI score, inflammation through downregulating NF‐κB signaling pathway. Hence, this study helps in the development of novel nutraceutical/functional food against psoriasis and thus could improve the quality of life in psoriasis patients. However, further clinical trials are needed to justify the above results before developing a commercial functional food using GRg1 against psoriasis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Ginsenoside Rg1 abolish imiquimod‐induced psoriasis‐like dermatitis in BALB/c mice via downregulating NF‐κB signaling pathway

Shi

Chen

et al. 2019

J Food Biochem

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“…The incidence of skin inflammatory diseases (dermatitis, psoriasis, rash) has increased significantly in the last decades and bioflavonoids such as quercetin, curcumin and baicalin have been widely used for treatment of this injures [1,2,3,4]. Citrus fruits peels represent an important source of phenolic acids and flavonoids, mainly polymethoxyflavones (PMFs), flavanones and glycosylated flavanones [5,6].…”

Section: Introductionmentioning

confidence: 99%

A novel ultradeformable liposomes of Naringin for anti-inflammatory therapy

Pleguezuelos-Villa

Mir-Palomo

Dı́ez-Sales

et al. 2018

Colloids and Surfaces B: Biointerfaces

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The article has 4636 words including ackwonledgment and references. The abstract has 127 words. There are 5 figures and 2 tables. Highlights Nanovesicles were small in size and monodispersed independently of the NA concentration. No citotoxity effects were observed in 3T3 fibroblasts treated with ultradeformable liposomes. Ultradeformable liposomes have the ability to reduce skin inflammation. Graphical abstract AbstractUltradeformable liposomes were formulated using naringin (NA), a flavanone glycoside, at different concentrations (3, 6 and 9 mg/mL). Nanovesicles were small size (~100 nm), regardless of the NA concentration used, and monodisperse (PI < 0.30). All formulations showed a high entrapment efficiency (~88%) and a highly negative zeta potential (around -30 mV). The selected formulations were highly biocompatible as confirmed by in vitro studies using 3T3 fibroblasts.In vitro assay showed that the amounts (%) of NA accumulated in the epidermis (~ 10%) could explain the anti-inflammatory properties of ultradeformable liposomes. In vivo studies confirmed the higher effectiveness of ultradeformable liposomes respect to betamethasone cream and NA dispersion in reducing skin inflammation in mice. Overall, it can conclude that NA ultradeformable liposomes can be considered as a promising formulation for the treatment of skin inflammatory diseases.

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The Role of Chronic Inflammation in Various Diseases and Anti‐inflammatory Therapies Containing Natural Products

Wang

Zhou

et al. 2021

ChemMedChem

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Chronic inflammation represents a long-term reaction of the body's immune system to noxious stimuli. Such a sustained inflammatory response sometimes results in lasting damage to healthy tissues and organs. In fact, chronic inflammation is implicated in the development and progression of various diseases, including cardiovascular diseases, respiratory diseases, metabolic diseases, neurodegenerative diseases, and even cancers. Targeting nonresolving inflammation thus provides new opportunities for treating relevant diseases. In this review, we will go over several chronic inflammation-associated diseases first with emphasis on the role of inflammation in their pathogenesis. Then, we will summarize a number of natural products that exhibit therapeutic effects against those diseases by acting on different markers in the inflammatory response. We envision that natural products will remain a rich resource for the discovery of new drugs treating diseases associated with chronic inflammation.

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Quercetin ameliorates imiquimod-induced psoriasis-like skin inflammation in mice via the NF-κB pathway

Cited by 119 publications

References 53 publications

Ginsenoside Rg1 abolish imiquimod‐induced psoriasis‐like dermatitis in BALB/c mice via downregulating NF‐κB signaling pathway

Ginsenoside Rg1 abolish imiquimod‐induced psoriasis‐like dermatitis in BALB/c mice via downregulating NF‐κB signaling pathway

A novel ultradeformable liposomes of Naringin for anti-inflammatory therapy

The Role of Chronic Inflammation in Various Diseases and Anti‐inflammatory Therapies Containing Natural Products

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