Quercetin alleviates rheumatoid arthritis by inhibiting neutrophil inflammatory activities

Yuan, Kai; Zhu, Qingqing; Lu, Qing‐Yi; Jiang, Haixu; Zhu, Mengmeng; Li, Xiaohong; Huang, Guangrui; Xu, Anlong

doi:10.1016/j.jnutbio.2020.108454

Cited by 106 publications

(64 citation statements)

References 32 publications

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“…The results of the conducted research indicate that the leaves of most of the analyzed poplars are a rich source of quercetin derivatives, such as rutin (peak 6) or isoquercetin (peak 9) ( Table 2, Figures 1 and 3) – known as strong antioxidants. In recent years, a number of studies indicate anti‐inflammatory effects of quercetin and its derivative – rutin, among others, in rheumatic arthritis, based on different mechanisms of action [43–46] . This suggests that poplar leaf extracts with a high content of flavonols may be a particularly interesting plant material for further research in the context of their use in the treatment of rheumatic diseases.…”

Section: Resultsmentioning

confidence: 99%

“…The leaves of three poplars, P. alba , P. simonii and P.×berolinensis , are a rich source of salicylic compounds and contain high concentrations of flavonoids. Basing on the literature data, [1,42–46] it is very well‐known that flavonoids and salicylic compounds, which also occur in poplars exert an anti‐inflammatory effect by inhibiting various stages of the arachidonic acid cascade. The presence of compounds with antioxidant properties, which partially decide about anti‐inflammatory effect of raw plant materials, was observed in all analyzed poplar leaves.…”

Section: Discussionmentioning

confidence: 99%

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Studies on the Polyphenolic Composition and the Antioxidant Properties of the Leaves of Poplar (Populus spp.) Various Species and Hybrids

Pobłocka-Olech

Głód

Jesionek

et al. 2021

Chemistry & Biodiversity

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The chemical composition in terms of flavonoid and salicylic compounds of leaves from 6 species and 3 hybrids of poplars (Populus) was identified with the use of TLC and HPLC‐DAD/ESI‐MS methods. Chromatographic analyses were carried out with 21 standard compounds including salicylic compounds (2), phenolic acids (3) and flavonoids (16). Moreover, on the basis of the obtained chromatographic data from the HPLC‐DAD/ESI‐MS and TLC separations, the presence of salicortin, tremulacin and chlorogenic acid was confirmed, depending on the analyzed poplar species or hybrid. The content of salicylic compounds was determined by HPLC‐UV method and expressed on salicin as free and total fraction. Total flavonoid content was determined by spectroscopic method as quercetin equivalent. Significant qualitative and quantitative differences in the chemical composition of the analyzed leaves were demonstrated. The highest concentration of flavonoids (8.02 mg/g) was found in the leaves of Populus nigra, while the highest content of salicylic compounds (47.14 mg/g) was found in the leaves of P.×berolinensis. The antioxidant and xanthine oxidase inhibition properties of extracts from poplar leaves were investigated by TLC bioautography. It has been shown that the richest set of compounds with antioxidant properties are present in the leaves of P. alba, P.×candicans and P. nigra.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Studies on the Polyphenolic Composition and the Antioxidant Properties of the Leaves of Poplar (Populus spp.) Various Species and Hybrids

Pobłocka-Olech

Głód

Jesionek

et al. 2021

Chemistry & Biodiversity

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“…In in vivo studies ( 39 – 41 ), quercetin has reduced arthritic scores and improved symptoms significantly in RA mice via inhibiting neutrophil infiltration and reducing levels of pro-inflammatory cytokines such as interferon γ, TNF-α, monocyte chemotactic protein 1, IL-6, and IL-17. It also inhibited neutrophil extracellular trap formation by suppressing autophagy ( 42 ). In another study, in a murine arthritis model, quercetin treatment reduced IL-1β and TNF-α release, and inhibited levels of pre-pro-endothelin 1 and cyclooxygenase 2 mRNA by inhibiting the activation of NF-κB and heme oxygenase 1/Nrf2 signaling ( 43 ).…”

Section: Quercetin and Autoimmune Diseasesmentioning

confidence: 99%

Potential Implications of Quercetin in Autoimmune Diseases

et al. 2021

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Autoimmune diseases are a worldwide health problem with growing rates of morbidity, and are characterized by breakdown and dysregulation of the immune system. Although their etiology and pathogenesis remain unclear, the application of dietary supplements is gradually increasing in patients with autoimmune diseases, mainly due to their positive effects, relatively safety, and low cost. Quercetin is a natural flavonoid that is widely present in fruits, herbs, and vegetables. It has been shown to have a wide range of beneficial effects and biological activities, including anti-inflammation, anti-oxidation, and neuroprotection. In several recent studies quercetin has reportedly attenuated rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, and systemic lupus erythematosus in humans or animal models. This review summarizes the evidence for the pharmacological application of quercetin for autoimmune diseases, which supports the view that quercetin may be useful for their prevention and treatment.

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“…According to published data, different bioactive compounds commonly seen in honey have an effective role decreasing intraarticular injuries by inhibiting inflammation, oxidative stress, synovial hyperplasia and angiogenesis (Wang et al, 2007;Yang et al, 2018;Li et al, 2019;Orhan and Deniz, 2020;Yuan et al, 2020). Specifically, cartilage protection and enhancement of chondrocyte reparative functions induced by honey, involve several biologically active molecules such as chrysin, apigenin, quercetin, baicalin, luteolin, fisetin, butein, among other flavonoids and phenolic compounds.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Potential of Bioactive Compounds in Honey for Treating Osteoarthritis

et al. 2021

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Dysregulation of joint tissue homeostasis induces articular degenerative changes and musculoskeletal diseases such as osteoarthritis. This pathology represents the first cause of motor disability in individuals over 60 years of age, impacting their quality of life and the costs of health systems. Nowadays, pharmacological treatments for cartilage disease have failed to achieve full tissue regeneration, resulting in a functional loss of the joint; therefore, joint arthroplasty is the gold standard procedure to cure this pathology in severe cases of Osteoarthritis. A different treatment is the use of anti-inflammatory drugs which mitigate pain and inflammation in some degree, but without significant inhibition of disease progression. In this sense, new therapeutic alternatives based on natural compounds have been proposed to delay osteoarthritis progression, particularly those agents that regulate articular homeostasis. Preclinical studies have shown a therapeutic application of honey and its bioactive compounds, ranging from treating wounds, coughs, skin infections, and are also used as a biological stimulant by exerting antioxidant and anti-inflammatory properties. In this article, we reviewed the current medicinal applications of honey with particular emphasis on its use regulating articular homeostasis by inhibiting inflammation and oxidative stress.

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Quercetin alleviates rheumatoid arthritis by inhibiting neutrophil inflammatory activities

Cited by 106 publications

References 32 publications

Studies on the Polyphenolic Composition and the Antioxidant Properties of the Leaves of Poplar (Populus spp.) Various Species and Hybrids

Studies on the Polyphenolic Composition and the Antioxidant Properties of the Leaves of Poplar (Populus spp.) Various Species and Hybrids

Potential Implications of Quercetin in Autoimmune Diseases

Therapeutic Potential of Bioactive Compounds in Honey for Treating Osteoarthritis

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