Abstract:Background and Objective: Glycogen synthase kinase (GSK-3β) play central role in Ischemic Pre Conditioning (IPC) mediated early as well as late effect of cardioprotection. The signaling pathway of IPC gets diminished during diabetes mellitus. The present study was designed to investigate the whether GSK-3β inhibitors, administered 24 h before the ischemia, would exert the cardioprotection in diabetic rat. Methods: Diabetes Mellitus (DM) was induced by single administration of streptozotocin (STZ) (50 mg kgG 1 … Show more
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