Quercetin, a flavonoid, inhibits proliferation and increases osteogenic differentiation in human adipose stromal cells

Kim, Yeon Jeong; Bae, Yong Chan; Suh, Kuen Tak; Jung, Jin Sup

doi:10.1016/j.bcp.2006.08.021

Cited by 93 publications

(74 citation statements)

References 54 publications

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“…12 Kim et al showed that antiproliferative effect of quercetin is mediated via inhibition of PI-3 kinase in cancer cells. 24 Our results revealed that resveratrol treatment induced a dose-dependent increase in the percentage of cells in G0/G1 phase, which was accompanied by a corresponding reduction in the percentage of cells in S phase. A number of studies reported that variety of different human cancer cell lines, treated with resveratrol at micromolar concentrations, arrested the cell cycle progression in S phase 39 or less frequently in the G2/M phase.…”

Section: Discussionsupporting

confidence: 48%

“…Quercetin-induced inhibition of cell proliferation has been reported for various cancer cells. 24 Caspase-3, a key factor in apoptosis execution, is the active form of procaspase-3 25 whose activation downstream in the apoptotic cascade is essential for leukemia cell apoptosis. 26 We used an approach similar to that in a previous study in which we tested the effect of resveratrol on caspase-3 activity in CLL cells.…”

Section: Discussionmentioning

confidence: 99%

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Resveratrol and quercetin-induced apoptosis of human 232B4 chronic lymphocytic leukemia cells by activation of caspase-3 and cell cycle arrest

2013

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Chronic lymphocytic leukemia (CLL), defined by accumulation of pathogenic B cells, has a very complex biology due to various factors such as inherited, host, and enviromental factors. Recently, finding new therapeutic agents or development of novel treatment strategies have been paid attention. Resveratrol and quercetin, important phytoalexins found in many plants, have been reported to have cytotoxic effects on various types of cancer. In this study, we examined cytotoxic, cytostatic, and apoptotic effects of these two important phenolic compounds on 232B4 human CLL cells. Cytotoxic effects of resveratrol and quercetin were determined by MTT cell proliferation assay. Changes in caspase-3 enzyme activity were measured using caspase-3 colorimetric assay. Annexin V-FITC/PI double staining was performed to measure apoptotic cell population. Effects of resveratrol and quercetin on cell cycle profiles of CLL cells were investigated by flow cytometry. Treatment of CLL cells with resveratrol and quercetin caused dose dependent inhibition of cell proliferation and increased apoptotic cell population through induction of caspase-3 activity. Cell cycle analysis displayed cell cycle arrest mainly in G0/G1 for both polyphenols. Our data, in total, showed for the first time that resveratrol and quercetin might block CLL growth through inducing apoptosis and cell cycle arrest.

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Section: Discussionsupporting

confidence: 48%

Section: Discussionmentioning

confidence: 99%

Resveratrol and quercetin-induced apoptosis of human 232B4 chronic lymphocytic leukemia cells by activation of caspase-3 and cell cycle arrest

2013

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“…Flavonoids, which are found in many plants and vegetables, especially onions and broccoli, as well as in green tea, apples, and grapes, have anti-inflammatory, anticoagulant, antibacterial, and antihypertensive effects (2)(3)(4)(5). Numerous epidemiological studies have demonstrated a relationship between the consumption of quercetin by enhance the treatment of cardiovascular diseases, lung cancer, asthma, and other respiratory disorders (6).…”

Section: Introductionmentioning

confidence: 99%

A Comparison of the Effects of Quercetin Hydrate With Those of Vitamin E on the Levels of IL-13, PDGF, TNF-α, and INF-γ in Bleomycin-Induced Pulmonary Fibrosis in Rats

Malayeri

Hemmati

Arzi

et al. 2016

Jundishapur J Nat Pharm Prod

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“…Natural compounds, such as antioxidants (e.g., epigallocatechin-3-gallate derived from green tea) and other flavonoids (e.g., resveratrol and quercetin), induce differentiation of mesenchymal stem cells (MSCs) to osteoblasts and enhance formation of bone nodules. [4][5][6][7] Additionally, histone deacetylase inhibitors, such as valproic acid, trichostatin A, and sodium butyrate, alter transcription of genes related to osteogenic differentiation by modifying chromatin structure and may also be promising candidates. 8,9 Ethyl-3,4-dihydroxybenzoate (EDHB) is a component of the Rubus coreanus extract (Fig.…”

Section: Introductionmentioning

confidence: 99%

Ethyl-3,4-Dihydroxybenzoate with a Dual Function of Induction of Osteogenic Differentiation and Inhibition of Osteoclast Differentiation for Bone Tissue Engineering

Kwon

Lee

Koo

et al. 2014

Tissue Engineering Part A

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The current approach in biomaterial design of bone implants is to induce in situ regeneration of bone tissue, thus improving integration of the implants and reducing their failure. Therefore, ethyl-3,4-dihydroxybenzoate (EDHB), which stimulates differentiation of osteoblasts and the resultant bone formation, should be studied. In this study, the osteoinductive ability of EDHB in preosteoblasts and human mesenchymal stem cells was examined. EDHB for future use in bone tissue engineering was evaluated by examination of early markers of differentiation (such as alkaline phosphatase [ALP] activity and collagen type I expression) and late markers of osteoblast differentiation (bone nodule formation). As bone remodeling and implant osteointegration depend not only on osteoblast response but also on interaction of the biomaterial with bone-resorbing osteoclasts, differentiation of osteoclasts in response to the compounds was also observed. For in vivo study, alginate gel comprised of EDHB and cells was transplanted into the back subcutis of mice. Our results show that EDHB might have beneficial effects through regulation of both osteoblast and osteoclast differentiation. Therefore, we suggest that EDHB could be a strong candidate for dual regulation to increase osteoblast differentiation and decrease osteoclast differentiation.

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Quercetin, a flavonoid, inhibits proliferation and increases osteogenic differentiation in human adipose stromal cells

Cited by 93 publications

References 54 publications

Resveratrol and quercetin-induced apoptosis of human 232B4 chronic lymphocytic leukemia cells by activation of caspase-3 and cell cycle arrest

Resveratrol and quercetin-induced apoptosis of human 232B4 chronic lymphocytic leukemia cells by activation of caspase-3 and cell cycle arrest

A Comparison of the Effects of Quercetin Hydrate With Those of Vitamin E on the Levels of IL-13, PDGF, TNF-α, and INF-γ in Bleomycin-Induced Pulmonary Fibrosis in Rats

Ethyl-3,4-Dihydroxybenzoate with a Dual Function of Induction of Osteogenic Differentiation and Inhibition of Osteoclast Differentiation for Bone Tissue Engineering

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