QuEChERS Approach for the Analysis of Three Fluoroquinolone Antibiotics in Wastewater: Concentration Profiles and Ecological Risk in Two Nigerian Hospital Wastewater Treatment Plants

Ajibola, Akinranti S.; Amoniyan, Oluwasegun A.; Ekoja, Faith Omeyi; Ajibola, Florence O.

doi:10.1007/s00244-020-00789-w

Cited by 23 publications

(5 citation statements)

References 46 publications

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“…Measured concentrations of diclofenac (41 µg L -1 ) and ibuprofen (60 µg L -1 ) in Dandaru river (UCH effluent receiving water) were higher than the corresponding concentrations in UCH effluent (37 µg L -1 for diclofenac and <LOQ for ibuprofen). Dandaru River flows through the Agodi gardens which is a recreational environment for tourists (Ajibola et al 2020b). Therefore, the higher concentrations of both compounds in Dandaru River than in UCH effluent could be attributed to contributions from other emission sources such as disposal of unused and expired drugs into the river.…”

Section: Resultsmentioning

confidence: 99%

Analysis, Occurrence and Ecological Risk Assessment of Diclofenac and Ibuprofen Residues in Wastewater from Three Wastewater Treatment Plants in South-Western Nigeria

Ajibola¹,

Adebiyi²,

Nwaeke³

et al. 2021

jasem

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Despite the frequent detection of non-steroidal anti-inflammatory drugs (NSAIDs) worldwide in the aquatic environment, there is currently a paucity of studies from Africa, including Nigeria, on the occurrence and potential ecological risks of two commonly used NSAIDs diclofenac and ibuprofen in wastewater and effluent receiving water. In this work, diclofenac and ibuprofen were determined in wastewater from three wastewater treatment plants (WWTPs) and effluent receiving water in South-Western Nigeria. Instrumental analysis was performed by high-performance liquid chromatography. Ecological risk was assessed for four trophic levels: fish, daphnia, algae and bacteria. The method quality parameters were satisfactory for the accurate determination of target NSAIDs in wastewater and effluent receiving water. Maximum concentrations of diclofenac and ibuprofen in wastewater were 166.1 µg L-1 (UCH influent) and 62.0 µg L-1 (Ijaiye effluent), respectively. Ibuprofen posed high risk to fish in all effluent and effluent receiving water samples. Bacteriawere the most sensitive organisms to the presence of diclofenac while fish was the most sensitive to ibuprofen. To the best of our knowledge, this is the first report on the occurrence and ecological risk assessment of diclofenac and ibuprofen residues in wastewater from Nigerian municipal and hospital WWTPs. More efficient wastewater treatment processes and technologies are recommended for the investigated WWTPs to reduce the discharge of target NSAIDs and other pharmaceuticals into the Nigerian aquatic environment. Keywords: Non-steroidal anti-inflammatory drugs, wastewater, ecological risk assessment, Nigeria

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Section: Resultsmentioning

confidence: 99%

Analysis, Occurrence and Ecological Risk Assessment of Diclofenac and Ibuprofen Residues in Wastewater from Three Wastewater Treatment Plants in South-Western Nigeria

Ajibola¹,

Adebiyi²,

Nwaeke³

et al. 2021

jasem

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“…Among all antibiotics, fluoroquinolone groups (levofloxacin, ciprofloxacin, and norfloxacin) are the most commonly detected in wastewater treatment plants (Hamjinda et al 2018). They are excreted in unmetabolized form, ~ 70% for levofloxacin, 30% for norfloxacin, and 40% for ciprofloxacin (Ajibola et al 2021). Levofloxacin is a third-generation fluoroquinolone compound that is listed as an essential medicine in the World Health Organization (Sitovs et al 2021;WHO 2019).…”

Section: Introductionmentioning

confidence: 99%

“…In Kenya, the levels of levofloxacin in river water and wastewater were 0.04 and 1.60 μg L −1 , respectively (K'Oreje et al 2016). In Nigeria, the levels of levofloxacin ranged from 0.1 to 0.3 mg L −1 in the effluents of hospitals (Ajibola et al 2021). In addition, levofloxacin levels in wastewater streams were found to be 6.63 mg L −1 in Pakistan and 0.54 mg L −1 in India (Zafar et al 2021;Gothwal and Shashidhar 2017).…”

Section: Introductionmentioning

confidence: 99%

Decontamination of levofloxacin from water using a novel chitosan–walnut shells composite: linear, nonlinear, and optimization modeling

Mahmoud,

Fawzy

2023

Appl Water Sci

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Chitosan–walnut shells (Ch–W) composite was tested for the removal of levofloxacin from water. Various experimental factors were examined at different contact time intervals. The prepared composite exhibited maximum uptake capacity of 7.43 mg g−1 for levofloxacin with 0.5 g L−1 Ch–W dose at 45 min and pH = 7. Linear and nonlinear isotherm/kinetic models have been investigated, and the pertinency of the models was confirmed by correlation coefficients (R2) and error functions. Consequently, the adsorption of levofloxacin could be more accurately described by the nonlinear pseudo-second-order and Langmuir as well as Temkin models (R2 ˃ 0.98). Optimization modeling of levofloxacin was performed using a central composite design. The independent parameters; initial concentration, pH, and Ch–W dose, were selected while levofloxacin removal was the response. The maximum levofloxacin removal was 75.7% and 94.2% at concentrations of 4 mg L−1 and 2 mg L−1, respectively. Furthermore, 3D surface plots with the interaction effects of the investigated factors are presented. The developed model was reliable for further study and prediction owing to the closeness between the experimental and predicted values. The individual and interacting factors were found to be significant except for “concentration x dose” based on the ANOVA. The models confirmed the experimental results with R2, R2adjusted, and R2predicted values ˃ 0.939. The continuity adsorption cycles were tested for reuse and revealed that the removal of levofloxacin was decreased ~ 23% after six cycles. Hence, the prepared composite has the potential to remove antibiotics from water.

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“…A recent meta‐analysis of CIP concentration studies in the rivers revealed an increment (30.68 to 148.46 ng/L) between the five‐year periods 2007–2011 and 2012–2016 [4] . Moreover, up to 228 ng/L of CIP concentrations were found in WWTP influents; however, the effluents showed 0.9–4.7 % in CIP removal [5] …”

Section: Introductionmentioning

confidence: 99%

Interaction of Ciprofloxacin with Arabinose, Glucosamine, Glucuronic Acid and Rhamnose: Insights from Genetic Algorithm and Quantum Chemistry

et al. 2022

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A theoretical study of the ciprofloxacin interactions with glucuronic acid, arabinose, glucosamine, and rhamnose is presented. The most stable complexes were obtained through genetic algorithms starting from the neutral and zwitterion species of ciprofloxacin. The energy at the semiempirical level PM7 of the optimal structures of the complexes was the genetic algorithm‘s fitness function. The resulting complexes’ geometry was optimized at M062X−D3/6‐311++G** level of theory, and non‐covalent interactions were assessed through the reduced density gradient and quantum theory of atoms in molecules. The results show that the zwitterion species of ciprofloxacin favorably complex carbohydrates and can induce proton exchange between them. The molecular complexes from proton exchange are the most stable, followed by the complexes formed by the contact of the zwitterion species and the carbohydrate. The complexes formed by both neutral species were the least stable. The medium strength and strong (assisted by charge) hydrogen bonds, the XH⋅⋅⋅π and lone‐pair⋅⋅π interactions, were mainly present in the complexes. Proton exchange processes strengthen the interactions mentioned above.

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QuEChERS Approach for the Analysis of Three Fluoroquinolone Antibiotics in Wastewater: Concentration Profiles and Ecological Risk in Two Nigerian Hospital Wastewater Treatment Plants

Cited by 23 publications

References 46 publications

Analysis, Occurrence and Ecological Risk Assessment of Diclofenac and Ibuprofen Residues in Wastewater from Three Wastewater Treatment Plants in South-Western Nigeria

Analysis, Occurrence and Ecological Risk Assessment of Diclofenac and Ibuprofen Residues in Wastewater from Three Wastewater Treatment Plants in South-Western Nigeria

Decontamination of levofloxacin from water using a novel chitosan–walnut shells composite: linear, nonlinear, and optimization modeling

Interaction of Ciprofloxacin with Arabinose, Glucosamine, Glucuronic Acid and Rhamnose: Insights from Genetic Algorithm and Quantum Chemistry

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