Que sera la chirurgie de la cataracte du futur ? Alternatives et voies de développement

Hassani, Rachid Tahiri Joutei; Sandali, Otman; Ouadfel, A.; Packer, Mark; Romano, Fabrizio; Thuret, Gilles; Gain, P.; Smet, Marc D. de; Baudouin, Christophe

doi:10.1016/j.jfo.2020.05.006

Journal Français d'Ophtalmologie

2020

DOI: 10.1016/j.jfo.2020.05.006

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Que sera la chirurgie de la cataracte du futur ? Alternatives et voies de développement

Rachid Tahiri Joutei Hassani

Otman Sandali

A. Ouadfel

et al.

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Cited by 3 publications

(2 citation statements)

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“…Annually, cataract surgery is performed on 20 million individuals worldwide, marking it as one of the most prevalent surgeries globally ( 1 ). The technique of phacoemulsification, introduced by Charles Kelman over five decades ago ( 2 ), continues to be the gold standard for cataract surgery ( 2 , 3 ).…”

mentioning

confidence: 99%

Editorial: Innovations in cataract surgery

Tahiri,

Albou-Ganem,

Gatinel

et al. 2024

Front. Med.

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confidence: 99%

Editorial: Innovations in cataract surgery

Tahiri,

Albou-Ganem,

Gatinel

et al. 2024

Front. Med.

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“…Moreover, cataract surgery is performed on approximately 20 million individuals globally annually, ranking it as one of the most frequently conducted surgeries worldwide ( 11 ). Numerous innovative surgical techniques have significantly enhanced the treatment of cataracts, including femtosecond laser-assisted cataract surgery (FLACS) and advanced intraocular lens (IOL) options such as multifocal and accommodative IOLs.…”

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confidence: 99%

Editorial: Insights in surgical ophthalmology: 2023

Guo,

Heindl

2024

Front. Ophthalmol.

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The discipline of Surgical Ophthalmology, as a distinct branch within ophthalmology, aims to alleviate patients' complaints through a range of surgical procedures. Recently, remarkable strides have been made in the rapidly evolving domain of surgical ophthalmology. Our Research Topic, titled "Insights in surgical ophthalmology: 2023", explores the cutting-edge research and advancements in this field, emphasizing novel perspectives, contemporary obstacles, future prospects, and sophisticated surgical techniques that promise to contribute to the ongoing progress within Surgical Ophthalmology. Consequently, Guo et al. emphasized the most pivotal challenges and recent advancements across all ophthalmic subspecialties, inspiring, informing, guiding, and motivating ophthalmologists to enhance their medical practices to improve patient care.Ocular surface disorders (OSD), which are highly prevalent, can significantly impact vision quality and overall quality of life, potentially leading to blindness in extreme cases. However, some treatments may be ineffective due to a limited understanding of OSD mechanisms. Fortunately, surgical advancements such as simple limbal epithelial transplantation (SLET) (1), corneal endothelial transplantation (2), and corneal neurotization for neurotrophic keratitis (3), among others, have significantly improved the management of severe OSDs. Innovative imaging technologies are also emerging as potential tools to enhance OSD prognosis. During Descemet membrane endothelial keratoplasty (DMEK) surgery, intraoperative optical coherence tomography (iOCT) provides crucial feedback for graft positioning. A recent study by Muijzer et al. involved a prospective, non-inferiority, international multicenter randomized controlled trial with 65 pseudophakic eyes of patients with Fuchs endothelial dystrophy scheduled for routine DMEK. The study found that iOCT-guided DMEK surgery, which avoids prolonged overpressurization, was at least as effective as the traditional method. Although the overall rate of adverse postoperative events remained unchanged, the surgery and unfolding times decreased. They presented iOCT's beneficial role in 40% of cases and considered it indispensable in 9% of the traditional cases.

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Aging, But Not Sex and Genetic Diversity, Impacts the Pathobiology of Bacterial Endophthalmitis

Singh

Wright

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. Age, sex, and genetics are important biological variables in determining an individual's susceptibility or response to infectious agents; however, their role has not been evaluated in intraocular infections. In this study, we comprehensively examined the impact of these host biological factors in the pathogenesis of experimental bacterial endophthalmitis. METHODS. Endophthalmitis was induced by intravitreal injection of bacteria (Staphylococcus aureus) in the eyes of male and female C57BL/6 mice of different ages: group I (young, 6-8 weeks), group II (mid-age, 18-20 weeks), and group III (old, 1 year). Highly heterogeneous outbred J:DO mice were used for genetic diversity analysis. Eyes were subjected to clinical examination, retinal function testing using electroretinography (ERG), histopathological analysis (hematoxylin and eosin staining), and bacterial burden estimation. The levels of inflammatory mediators were measured using qPCR and ELISA, and the infiltration of neutrophils was determined by flow cytometry. RESULTS. Both inbred C57BL/6 and diversity outbred (J:DO) mice were equally susceptible to S. aureus endophthalmitis, as evidenced by a time-dependent increase in clinical scores, bacterial burden, intraocular inflammation, and retinal tissue damage, in addition to decreased retinal function. However, no significant differences were observed in disease severity and innate responses in male versus female mice. Older mice (group III) exhibited higher clinical scores coinciding with increased bacterial proliferation and intraocular inflammation, resulting in enhanced disease severity. Moreover, bone-marrowderived macrophages from old mice exhibited reduced phagocytic activity but increased inflammatory response toward S. aureus challenge. CONCLUSIONS. Age, but not sex, is an important biological variable in bacterial endophthalmitis. Identification of pathways underlying altered innate immunity and impaired bacterial clearance in aging eyes could provide new insights into the pathobiology of intraocular infections in elderly patients.

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Que sera la chirurgie de la cataracte du futur ? Alternatives et voies de développement

Cited by 3 publications

References 41 publications

Editorial: Innovations in cataract surgery

Editorial: Innovations in cataract surgery

Editorial: Insights in surgical ophthalmology: 2023

Aging, But Not Sex and Genetic Diversity, Impacts the Pathobiology of Bacterial Endophthalmitis

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