“…In addition, defects in tyrosinase may cause some diseases such as albinism and vitiligo 15,16 . Tyrosinase from A. bisporus was reported to be a hetero tetramer comprising two heavy (H) and light (L) chains with a molecular mass of 120 kDa 17 . The enzyme tyrosinase has three domains, of which the central domain contains two Cu binding sites, called CuA and CuB.…”