Abstract:The present article describes how we devised new quaternary ammonium‐supported quench reagents (TAMA‐Cl and BAX‐sulfate) for scavenging acids and excess electrophiles from crude reaction mixtures. TAMA‐Cl is liquid at room temperature, but is very glutinous and has to be used in aqueous solution. It removes unchanged electrophiles very efficiently. An aqueous preparation of TAMA‐Cl may be easily added in automated syntheses, and high‐throughput phase‐separation techniques should allow purification of scavenger… Show more
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