Quaternary ammonium poly(diethylaminoethyl methacrylate) possessing antimicrobial activity

Farah, Shady; Aviv, Oren; Laout, Natalia; Ratner, S. B.; Beyth, Nurit; Domb, Abraham J.

doi:10.1016/j.colsurfb.2015.01.051

Cited by 32 publications

(21 citation statements)

References 22 publications

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“…Both of intermolecular ionic interactions of imidazolium salt groups and intramolecular actions between alkyl side chains and positively charged groups in imidazolium may provide thermodynamic driving force for micro-phase separation, which is an assumption in other reports. [39][40][41] Besides, the special heterogeneous morphology on magnetic block copolymer film surface generated from phase separation may affect antimicrobial activity.…”

Section: Morphology Of the Copolymer Filmsmentioning

confidence: 99%

Retracted: Controlled synthesis of magnetic block copolymers for anti‐microbial purpose

Zhao

2016

J of Applied Polymer Sci

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The above article from the Journal of Applied Polymer Science [Volume 134 (2017), Issue 11, 44598; version of record online: November 9, 2016] has been retracted by agreement between the author Hongjian Zhao, the Editor‐in‐Chief, Stefan Spiegel, and Wiley Periodicals, Inc. The retraction has been agreed following an investigation indicating that the majority of the paper is based on results not created by the author and used without permission from the original authors/scientists and the group of Prof. Xiaoyan Yuan, where the work was done. REFERENCES

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Section: Morphology Of the Copolymer Filmsmentioning

confidence: 99%

Retracted: Controlled synthesis of magnetic block copolymers for anti‐microbial purpose

Zhao

2016

J of Applied Polymer Sci

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“…This step of the experimental protocol appeared to have an effect on the findings because a reduction in the surviving number of bacteria was not confirmed for the samples stored in distilled water. Similar antibacterial activity for the non-stored and non-filled samples was not observed for E. coli , although Farah et al [47] and Lu et al [48] investigated the use of polymeric materials and reported significantly higher antibacterial activity against S. aureus than for E. coli . Several studies have reported that for antimicrobial additives and polymers, the effect against S. aureus was lower than that against E. coli [45,49,50], a difference that indicates significant variability in the results.…”

Section: Discussionmentioning

confidence: 62%

Effect of Storage in Distilled Water for Three Months on the Antimicrobial Properties of Poly(methyl methacrylate) Denture Base Material Doped with Inorganic Filler

et al. 2016

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The colonization of poly(methyl methacrylate) (PMMA) denture base materials by pathogenic microorganisms is a major problem associated with the use of prostheses, and the incorporation of antimicrobial fillers is a method of improving the antimicrobial properties of these materials. Numerous studies have demonstrated the initial in vitro antimicrobial effectiveness of this type of material; however, reports demonstrating the stability of these fillers over longer periods are not available. In this study, silver sodium hydrogen zirconium phosphate was introduced into the powder component of a PMMA denture base material at concentrations of 0.25%, 0.5%, 1%, 2%, 4%, and 8% (w/w). The survival rates of the gram-positive bacterium Staphylococcus aureus, gram-negative bacterium Escherichia coli and yeast-type fungus Candida albicans were established after fungal or bacterial suspensions were incubated with samples that had been previously stored in distilled water. Storage over a three-month period led to the progressive reduction of the initial antimicrobial properties. The results of this study suggest that additional microbiological tests should be conducted for materials that are treated with antimicrobial fillers and intended for long-term use. Future long-term studies of the migration of silver ions from the polymer matrix and the influence of different media on this ion emission are required.

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“…To improve the antibacterial properties or to pioneer new application fields of these antibiotics, numerous studies have been reported. However, most of them focused on synthesis of new antibacterial organic molecules (Kourai et al 2006;Chanawanno et al 2010;Shtyrlin et al 2016) or polymerization with R4N + (Jiao et al 2017;Farah et al 2015;Zaltsman et al 2016). That is, there is few report with respect to composites between metal or inorganic materials and antibiotic molecules.…”

Section: Introductionmentioning

confidence: 99%

Enhancement of antibacterial effect of quaternary ammonium with inorganic nanosheets against Enterobacter cloacae

et al. 2018

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To suppress nosocomial infections, numerous studies of quaternary ammonium cations (R4N +) to improve the antibiotic properties have been investigated. However, most of them reported developments of novel organic or polymeric materials with R4N +. To pioneer antibacterial inorganic materials hybridized with R4N + , a colloidal solution of metal oxide nanosheets, which have a small particle size (typically less than 10 nm), is considered to be a suitable option because oxide nanosheets with a negative surface charge strongly interact R4N +. Herein, we demonstrate for the first time that the high antibacterial/bactericidal effects of titanate nanosheets (TNS) adsorbing tetramethylammonium (TMA-TNS) or tetrabultylammonium ions (TBA-TNS). Their antibacterial effects against Enterobacter cloacae were evaluated using a colony forming unit (CFU) counting method. The results showed that the synthesized TNS composites had superior antibacterial and bactericidal effects to those of free R4N + and TBA-TNS exhibited the strongest effect (69% CFU reduction compared with that of free TBA + and 98% CFU reduction compared with the control) among the samples examined. Dark incubation was employed to ensure photocatalytic reaction of semiconducting TNS did not contribute to the process. Compared with TiO2 spherical particles, such high bactericidal effect would be induced by a synergistic function of TBA + and TNS, which physically damages bacteria due to long hydrophobic alkyl chains and an anisotropic nanocrystalline structure with sharp edges, respectively.

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Quaternary ammonium poly(diethylaminoethyl methacrylate) possessing antimicrobial activity

Cited by 32 publications

References 22 publications

Retracted: Controlled synthesis of magnetic block copolymers for anti‐microbial purpose

Retracted: Controlled synthesis of magnetic block copolymers for anti‐microbial purpose

Effect of Storage in Distilled Water for Three Months on the Antimicrobial Properties of Poly(methyl methacrylate) Denture Base Material Doped with Inorganic Filler

Enhancement of antibacterial effect of quaternary ammonium with inorganic nanosheets against Enterobacter cloacae

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