In this paper, we investigate the following nonlinear fractional Schrödinger equationwhere s ∈ (0, 1), N > 2 and (−∆) s is fractional Laplacian operator. We prove that the problem has a non-trivial solution under asymptotically periodic case of V and f at infinity. Moreover, the nonlinear term f does not satisfy any monotone condition and Ambrosetti-Rabinowitz condition.