In this article the notions of (quasi weakly hereditary) general closure operator C on a category X with respect to a class M of morphisms, and quasi factorization structures in a category X are introduced. It is shown that under certain conditions, if (E , M) is a quasi factorization structure in X , then X has quasi right M-factorization structure and quasi left E -factorization structure. It is also shown that for a quasi weakly hereditary and quasi idempotent QCD-closure operator with respect to a certain class M, every quasi factorization structure (E , M) yields a quasi factorization structure relative to the given closure operator; and that for a closure operator with respect to a certain class M, if the pair of classes of quasi dense and quasi closed morphisms forms a quasi factorization structure, then the closure operator is both quasi weakly hereditary and quasi idempotent. Several illustrative examples are furnished.