Quasi-linear relationship between Gibbs free energy of ATP hydrolysis and power output in human forearm muscle

Jeneson, Jeroen A. L.; Westerhoff, Hans V.; Brown, Truman R.; Echteld, C.J.A. van; Berger, Ruud

doi:10.1152/ajpcell.1995.268.6.c1474

Cited by 76 publications

(90 citation statements)

References 28 publications

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“…A uniquely strong point of 13 C MRS is the very wide chemical shift range of up to 200 ppm, which enables the differentiation of a multitude of chemical species and explains its widespread use in organic chemistry. However, the sensitivity of the 13 C nucleus is intrinsically low and its natural abundance is only 1.1%.…”

Section: Mrsmentioning

confidence: 99%

“…However, the sensitivity of the 13 C nucleus is intrinsically low and its natural abundance is only 1.1%. Therefore, the use of 13 C MRS for in vivo studies of skeletal muscle without isotope enrichment is essentially limited to materials that are present at high concentrations, in particular glycogen and triglycerides. Muscle levels of glycogen can be quantified from the intensity of the C-1 peak at 100.5 ppm.…”

Section: Mrsmentioning

confidence: 99%

“…The use of 13 C MRS to measure muscle glycogen has been pioneered by the Yale group (132-136). Jue et al (132) were the first to report on the detection of the natural abundance 13 C signal from the glycogen C-1 resonance and used this technique to measure glycogen turnover in human muscle (133,134). The glycogen C-1 resonance is 100% visible in spite of its high molecular weight (135), which is due to the high mobility of the a-1,4-glycosidic linkage.…”

Section: Mrsmentioning

confidence: 99%

“…3). From such a dataset, the kinetic transfer function of power-output and an index of the cytosolic free ADP concentration can be derived, yielding an estimate of the maximal mitochondrial ATP synthesis flux of the muscle (12,13). Accuracy of this particular approach, however, critically depends on quantification of contractile work on the one hand and restriction of 31 P MRS signal collection to the active muscle group(s) recruited during the exercise (14).…”

mentioning

confidence: 99%

“…The non-equilibrium thermodynamic model holds that respiration varies linearly with the thermodynamic driving force DG ATP during submaximal work (22). It was later shown that the precise relation is quasi-linear (13). The metabolic restraints imposed by the creatine kinase equilibrium make it impossible to distinguish the nonequilibrium thermodynamic control model from the kinetic control model when pH changes are small (20,24).…”

mentioning

confidence: 99%

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Dynamic MRS and MRI of skeletal muscle function and biomechanics

et al. 2006

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MR is a powerful technique for studying the biomechanical and functional properties of skeletal muscle in vivo in health and disease. This review focuses on 31 P, 1 H and 13 C MR spectroscopy for assessment of the dynamics of muscle metabolism and on dynamic 1 H MRI methods for non-invasive measurement of the biomechanical and functional properties of skeletal muscle. The information thus obtained ranges from the microscopic level of the metabolism of the myocyte to the macroscopic level of the contractile function of muscle complexes. The MR technology presented plays a vital role in achieving a better understanding of many basic aspects of muscle function, including the regulation of mitochondrial activity and the intricate interplay between muscle fiber organization and contractile function. In addition, these tools are increasingly being employed to establish novel diagnostic procedures as well as to monitor the effects of therapeutic and lifestyle interventions for muscle disorders that have an increasing impact in modern society.

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Section: Mrsmentioning

confidence: 99%

Section: Mrsmentioning

confidence: 99%

Section: Mrsmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Dynamic MRS and MRI of skeletal muscle function and biomechanics

et al. 2006

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Regulation of Oxidative and Glycogenolytic ATP Synthesis in Exercising Rat Skeletal Muscle Studied by31P Magnetic Resonance Spectroscopy

et al. 1996

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31P magnetic resonance spectroscopy measurements of pH and the concentrations of orthophosphate and phosphocreatine were used to estimate rates of glycogenolytic and oxidative ATP synthesis in rat leg muscle during 6 min sciatic nerve stimulation at different rates (1–4 Hz). To study the regulation of glycogenolysis during exercise, the apparent "glycogenolytic capacity' (LMAX) was calculated from glycogenolytic ATP synthesis rate and orthophosphate concentration as a measure of the Ca2+‐dependent activation of glycogen phosphorylase. This was found to be proportional to the total ATP synthesis rate (F), and to decline with time; expressed relative to total ATP turnover rate as LMAX/F, its initial value was 2.9±0.6, declining with half‐time 1.4±0.4 min. The apparent "mitochondrial capacity' (QMAX), calculated from oxidative ATP synthesis rate and [ADP], was independent of ATP turnover rate, but increased with half‐time 0.8±0.1 min to 29±2 mmol kg−1 min−1: thus [ADP] was the predominant but not the only influence on oxidative ATP synthesis. Numerical simulation shows that time‐dependent changes in LMAX>/F exert a strong influence on pH and on the concentrations of phosphocreatine and ADP

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