Quasi-isometric length parameterization of cortical sulci: Application to handedness and the central sulcus morphology

Coulon, Olivier; Lefèvre, Julien; Klöppel, Stefan; Siebner, Hartwig R.; Mangin, Jean‐François

doi:10.1109/isbi.2015.7164105

Cited by 12 publications

(7 citation statements)

References 12 publications

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“…While cortical folds and sulcal parameters can be affected by genetics and environmental factors, there is consistent similarity in the patterns of folds and sulci of healthy individuals. As shown in a study of handedness [4], the central sulcus starts and ends in similar locations and has dips in similar positions along the sulcal path. Subtle abnormalities in cortical folding patterns can be indicative of diseases such as ADHD, schizophrenia, autism or bipolar disorder [6], [7].…”

Section: Introductionmentioning

confidence: 90%

“…Cortical folding parameters such as sulcal depth can be a marker of functional specificities or developmental pathologies [2], [3]. Some studies have shown that sulcal depth varies for right handed and left handed participants in the central sulcus [4], [5]. While cortical folds and sulcal parameters can be affected by genetics and environmental factors, there is consistent similarity in the patterns of folds and sulci of healthy individuals.…”

Section: Introductionmentioning

confidence: 99%

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Central sulcus development in early childhood

Gajawelli

Deoni

Dirks

et al. 2017

2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

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Mapping out the development of the brain in early childhood is a critical part of understanding neurological disorders. The brain grows rapidly in early life, reaching 95% of the final volume by age 6. A normative atlas containing structural parameters that indicate development would be a powerful tool in understanding the progression of neurological diseases. Although some studies have begun exploring cortical development in pediatric imaging, sulci have not been examined extensively. Here, we study the changes in the Central Sulcus (CS), which is one of the earliest sulci to develop from the fetal stage, at early developmental age 1-3 years old using high resolution magnetic resonance images. Parameterization of the central sulcus was performed and results show us that the CS change corresponds to the development of the mouth and tongue regions.

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Section: Introductionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Central sulcus development in early childhood

Gajawelli

Deoni

Dirks

et al. 2017

2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

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“…A sulcal parameterization process was then applied to the left and right central sulci of each subject and depth was measured at each position along the sulcus, which resulted in a depth curve for each central sulcus, as described in [5, 6]. This method detects the dorsal and ventral extremities and provides a smooth isometric parameterization that, for every point on the sulcus, indicates its relative position between the two extremities [5]. For each position within [0 100], the depth at this position is estimated by measuring the length of the corresponding isoparametric lines.…”

Section: Methodsmentioning

confidence: 99%

Characterization of the central sulcus in the brain in early childhood

Gajawelli

Deoni

Dirks

et al. 2015

2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

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Characterization of the developing brain during early childhood is of interest for both neuroscience and medicine, and in particular, is key to understanding what goes wrong in neurodevelopmental disorders. In particular, the cortex grows rapidly in the first 3 years of life, and creating a normative atlas can provide a comparison tool to diagnose disorders at an early stage, thereby empowering early interventional therapies. Zooming in on specific sulci may provide additional targeted information, and notably, an understanding of central sulcus growth can provide important insight on the development of laterality. However, there currently do not exist any atlases of specific changes in sulci as the brain grows. In this pilot study, we explore regional differences in the depth of the central sulcus between two and three year old infants using brain magnetic resonance images.

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“…We isometrically parameterized the PreCG and PoCG crest lines, in an intrinsic manner, as proposed in (Coulon et al 2015), from the ventral (coordinate 0) to the dorsal end (coordinate 100). For a given streamline, its pre-central (resp.…”

Section: Short Structural Connectivity Profiles Of the Csmentioning

confidence: 99%

U-shape short-range extrinsic connectivity organisation around the human central sulcus

2020

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The central sulcus is probably one of the most studied folds in the human brain, owing to its clear relationship with primary sensory-motor functional areas. However, due to the difficulty of estimating the trajectories of the U-shape fibres from diffusion MRI, the short structural connectivity of this sulcus remains relatively unknown. In this context, we studied the spatial organization of these U-shape fibres along the central sulcus. Based on high quality diffusion MRI data of 100 right-handed subjects and state-of-the-art pre-processing pipeline, we first define a connectivity space that provide a comprehensive and continuous description of the short-range anatomical connectivity around the central sulcus at both the individual and group levels. We then infer the presence of five major U-shape fibre bundles at the group level in both hemispheres by applying unsupervised clustering in the connectivity space. We propose a quantitative investigation of their position and number of streamlines as a function of phenotypic traits such as sex and hemispheres and functional scores such as handedness and manual dexterity. Main findings of this study are twofold: a description of U-shape short-range connectivity along the central sulcus at group level and the evidence of a significant relationship between the position of three hand related U-shape fibre bundles and the handedness score of subjects.

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Quasi-isometric length parameterization of cortical sulci: Application to handedness and the central sulcus morphology

Cited by 12 publications

References 12 publications

Central sulcus development in early childhood

Central sulcus development in early childhood

Characterization of the central sulcus in the brain in early childhood

U-shape short-range extrinsic connectivity organisation around the human central sulcus

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