Quasi-Experimental Study of Sodium Citrate Locks and the Risk of Acute Hemodialysis Catheter Infection among Critically Ill Patients

Parienti, Jean‐Jacques; Deryckere, Stephanie; Mégarbane, Bruno; Valette, Xavier; Seguin, Amélie; Sauneuf, Bertrand; Mira, Jean‐Paul; Souweine, Bertrand; Cattoir, Vincent; Daubin, Cédric; Cheyron, Damien du

doi:10.1128/aac.03079-14

Cited by 14 publications

(34 citation statements)

References 39 publications

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“…In a randomized study including a mixed ICU and non-ICU population, minocyclinerifampicin-coated HDCs failed to decrease the rate of colonization, but did reduce infection (0/66 versus 7/64 CRBSI in the treatment versus control arm, respectively) [24]. Studies on the efficacy of non-antibiotic antimicrobial locks for preventing HDC infections have yielded conflicting results but differ by the types of lock solutions and duration of dwell time exposure [25][26][27].…”

Section: Hemodialysis Cathetersmentioning

confidence: 99%

“…The extrapolation of these studies to short-term catheters inserted in critically ill patients is questionable because of differences in catheter type, use, and accessibility for ALT. Studies on ALT in ICU patients are scarce and addressed mainly hemodialysis catheters, since their lumens are idle and available for ALT only between renal replacement therapy sessions [25][26][27]. The results of a large study comparing interdialytic lock with unfractionated heparin and 4% citrate are not yet available [101].…”

Section: Catheter Lock For Preventing Thrombotic and Infectious Complmentioning

confidence: 99%

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A state of the art review on optimal practices to prevent, recognize, and manage complications associated with intravascular devices in the critically ill

et al. 2018

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Intravascular catheters are inserted into almost all critically ill patients. This review provides up-to-date insight into available knowledge on epidemiology and diagnosis of complications of central vein and arterial catheters in ICU. It discusses the optimal therapy of catheter-related infections and thrombosis. Prevention of complications is a multidisciplinary task that combines both improvement of the process of care and introduction of new technologies. We emphasize the main component of the prevention strategies that should be used in critical care and propose areas of future investigation in this field.

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Section: Hemodialysis Cathetersmentioning

confidence: 99%

Section: Catheter Lock For Preventing Thrombotic and Infectious Complmentioning

confidence: 99%

A state of the art review on optimal practices to prevent, recognize, and manage complications associated with intravascular devices in the critically ill

et al. 2018

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“…27 Only few studies were conducted in critically ill patients and focused only on short-term dialysis catheters. 18,118,119 Souweine et al demonstrated that a 2-minute 60% ethanol lock is not able to decrease the rate of intravascular catheter infections in short-term hemodialysis catheters of ICU patients. 18 The results of a large study comparing interdialytic lock with unfractionated heparin and citrate as a catheter locking solution for nontunneled central venous hemodialysis catheters are not yet available.…”

Section: Systemic Antibiotic or Antiseptic Lock Solutionsmentioning

confidence: 99%

Management and Prevention of Central Venous Catheter-Related Infections in the ICU

Buetti

Timsit

2019

Semin Respir Crit Care Med

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Central venous catheter-related bloodstream infections (CR-BSI) are a frequent event in the intensive care unit (ICU) setting. In contrast to other nosocomial infections, most risk factors for CR-BSI are linked to the device and can be prevented efficiently. Rates of CR-BSI higher than 1 per 1,000 catheter days are no longer acceptable. A continuous quality improvement program is effective to reduce them. Key elements of prevention of CR-BSI are hand hygiene, avoidance of insertion of unnecessary catheters, full sterile barrier precautions at insertion, preferential use of subclavian venous insertion site, cutaneous antisepsis with 2% chlorhexidine alcoholic preparation, use of chlorhexidine-impregnated dressings, immediate replacement of moistened or detached catheter dressings, and removal of catheters as soon as possible. Audit and feedback of the process of care, infection rates, and periodic re-education of health care providers are other instrumental tools in the prevention of CR-BSI. Catheter removal is the main therapeutic intervention, especially recommended in the case of sepsis or shock. While awaiting culture results, an empiric antimicrobial treatment of CR-BSI should target gram-positive microorganism (i.e., Staphylococcus aureus) and gram-negative coverage should be based on clinical variables, patients' risk factors, and previous colonization status. While a short course of antimicrobials (7 days) is sufficient for noncomplicated CR-BSI, a longer course of 14 days should be preferred for uncomplicated S. aureus and Candida CR-BSI. In case of persisting fever or positive blood culture after 3 days despite adequate antimicrobial therapy and catheter removal, catheter-related complications (e.g., endocarditis, thrombophlebitis, septic metastasis) should be ruled out.

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“…11/2014 (23) Comparar os riscos de infecção dos cateteres de diálise de acordo com a escolha da solução de bloqueio utilizada, em pacientes de uma unidade de terapia intensiva (UTI), durante o período interdialítico.…”

Section: Estudo Retrospectivo (Nível Iii)unclassified

“…A solução de minociclina e EDTA, em comparação à heparina não fracionada, também foi analisada e obteve resultado positivo em relação à diminuição de bacteremia (17) . O citrato esteve relacionado com uma redução no risco de colonização da ponta do cateter e também com menores ín-dices de disfunção do cateter (23) . (25) .…”

Section: Em Um Dos Estudos As Infecções Por S Aureusunclassified

Infecção Da Corrente Sanguínea Relacionada a Cateter Venoso Central Para Hemodiálise: Revisão Integrativa

et al. 2017

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Objetivo: identificar evidências científicas presentes nas publicações relacionadas à infecção em cateter venoso central para hemodiálise. Método: revisão integrativa de literatura. A busca foi realizada nas bases de dados Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS) e Biblioteca Nacional de Medicina dos Estados Unidos (PubMed), no mês de dezembro de 2015. Resultados: os 13 estudos analisados demonstraram altos índices de infecção relacionados a cateter, sendo o Staphylococcus aureus o micro-organismo mais observado. Alguns fatores de risco para infecção citados, relacionados ao paciente, foram hipertensão, diabetes mellitus e hipoalbuminemia. O tempo de uso do cateter esteve entre os fatores de risco para infecção. Conclusão: os resultados apresentam possíveis alternativas que podem auxiliar na prevenção e redução das infecções relacionadas ao cateter.Descritores: Enfermagem Baseada em Evidências; Revisão; Infecções Relacionadas a Cateter. Objective: identify the scientific evidence present in publications related to central venous catheter-related infection in hemodialysis. Method: integrative literature review. The search was conducted in the databasesof the Latin American and Caribbean Center on Health Sciences Information (LILACS) and the United States National Library of Medicine

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Quasi-Experimental Study of Sodium Citrate Locks and the Risk of Acute Hemodialysis Catheter Infection among Critically Ill Patients

Cited by 14 publications

References 39 publications

A state of the art review on optimal practices to prevent, recognize, and manage complications associated with intravascular devices in the critically ill

A state of the art review on optimal practices to prevent, recognize, and manage complications associated with intravascular devices in the critically ill

Management and Prevention of Central Venous Catheter-Related Infections in the ICU

Infecção Da Corrente Sanguínea Relacionada a Cateter Venoso Central Para Hemodiálise: Revisão Integrativa

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