Quasi-conformal statistical shape analysis of hippocampal surfaces for Alzheimer׳s disease analysis

Chan, Hei Long; Li, Hangfan; Lui, Lok Ming

doi:10.1016/j.neucom.2015.10.047

Cited by 21 publications

(13 citation statements)

References 48 publications

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“…The main factors causing the disease are not known. However, it is clear that AD is a nonstop disease; therefore, the patient's death is inevitable (Chan et al, 2016). Many treatment treatment strategies have been developed for AD so far; however, the progression of the disease could not be stopped (Zhao et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Improvement of memory deficits via acetylcholinesterase inhibitory activity of Nepeta nuda ssp. nuda essential oil in rats

Akbaba

Bağcı²,

Hrițcu³

et al. 2021

KJS publishes peer-review articles in Mathematics, Computer Sci

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Nepeta L. (Lamiaceae) species are belonging to aromatic and medicinal plants. Many biological activities of Nepeta species have been reported. In this study, memory-enhancing activities of Nepeta nuda ssp. nuda essential oil was aimed to be evaluated in laboratory rats treated with scopolamine. GC-MS/GC-FID system was used to identify oil composition. Memory performances of the rats were tested using Y-maze and radial-arm maze. Acetylcholinesterase enzyme activity and molecular docking analysis were also performed in this study. In total, 44 different compounds were identified in Nepeta nuda ssp. nuda essential oil. Trans-cis nepetalactone was showed to be the most abundant constituent in the oil. In the Y-maze test, the oil improved the performances of the animals on spontaneous alternation. Besides, in the radial-arm maze test, the oil improved working and reference memory significantly impaired in the rats subjected to scopolamine. The oil also showed acetylcholinesterase inhibitory activity in vitro. The molecular docking method, in the meantime, revealed that some of the compounds in the oil could interact with the acetylcholinesterase enzyme, theoretically. Nepeta nuda ssp. nuda essential oil improved spatial memory of scopolamine-induced rats. Neuroprotective effects of the oil are probably related to the anti-cholinesterase activity of the oil. Therefore, Nepeta nuda ssp. nuda essential oil could be used as a complementary therapy to improve memory in Alzheimer’s and related diseases.

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Section: Introductionmentioning

confidence: 99%

Improvement of memory deficits via acetylcholinesterase inhibitory activity of Nepeta nuda ssp. nuda essential oil in rats

Akbaba

Bağcı²,

Hrițcu³

et al. 2021

KJS publishes peer-review articles in Mathematics, Computer Sci

View full text Add to dashboard Cite

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“…The deformation map is obtained by finding an optimal quasiconformal mapping. Quasiconformal mappings have been widely used for different imaging tasks [45], including image registration [58,20,59,42,56,41] and image analysis [18,9,19,47,60]. Since the deformation map is bijective, the topology-preserving property can be guaranteed.…”

Section: Introductionmentioning

confidence: 99%

Topology-Preserving 3D Image Segmentation Based On Hyperelastic Regularization

Zhang

Lui

2021

Preprint

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Image segmentation is to extract meaningful objects from a given image. For degraded images due to occlusions, obscurities or noises, the accuracy of the segmentation result can be severely affected. To alleviate this problem, prior information about the target object is usually introduced. In [10], a topology-preserving registration-based segmentation model was proposed, which is restricted to segment 2D images only. In this paper, we propose a novel 3D topologypreserving registration-based segmentation model with the hyperelastic regularization, which can handle both 2D and 3D images. The existence of the solution of the proposed model is established. We also propose a converging iterative scheme to solve the proposed model. Numerical experiments have been carried out on the synthetic and real images, which demonstrate the effectiveness of our proposed model.

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“…This inaccuracy may compromise the comparison between the geometry of different tooth shapes. In recent years, conformal and quasi-conformal mappings have been considered for the analysis of medical and biological shapes such as brain cortical surfaces [11,12], hippocampi [13,14], vestibular systems [15], carotid arteries [16] and insect wings [17,18].…”

Section: Introductionmentioning

confidence: 99%

“…Illustration of our framework is done by applying the new algorithms to a dataset of tooth occlusal surfaces from Indigenous Australians [19] and Australians of European ancestry [20] (see Figure 1 for examples). More specifically, to capture and quantify the shape differences between the 3D surfaces in terms of the overall shape, the curvature and the positions of the anatomical landmarks, we extend our previous work on landmark-matching Teichmüller map [21] to achieve an accurate 1-1 mapping between them, and further develop a quasi-conformal shape analysis model based on our previous work [14] for performing a classification. The classification results for the tooth Figure 1: Examples of the second upper premolar occlusal surfaces from two populations in Australia [19,20], with four landmarks of the buccal cusp, the lingual cusp, the mesial fossa pit and the distal fossa pit highlighted in red.…”

Section: Introductionmentioning

confidence: 99%

Tooth morphometry using quasi-conformal theory

Choi

Chan

Yong

et al. 2020

Pattern Recognition

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Shape analysis is important in anthropology, bioarchaeology and forensic science for interpreting useful information from human remains. In particular, teeth are morphologically stable and hence well-suited for shape analysis. In this work, we propose a framework for tooth morphometry using quasi-conformal theory. Landmark-matching Teichmüller maps are used for establishing a 1-1 correspondence between tooth surfaces with prescribed anatomical landmarks. Then, a quasi-conformal statistical shape analysis model based on the Teichmüller mapping results is proposed for building a tooth classification scheme. We deploy our framework on a dataset of human premolars to analyze the tooth shape variation among genders and ancestries.Experimental results show that our method achieves much higher classification accuracy with respect to both gender and ancestry when compared to the existing methods. Furthermore, our model reveals the underlying tooth shape difference between different genders and ancestries in terms of the local * Corresponding author.

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Quasi-conformal statistical shape analysis of hippocampal surfaces for Alzheimer׳s disease analysis

Cited by 21 publications

References 48 publications

Improvement of memory deficits via acetylcholinesterase inhibitory activity of Nepeta nuda ssp. nuda essential oil in rats

Improvement of memory deficits via acetylcholinesterase inhibitory activity of Nepeta nuda ssp. nuda essential oil in rats

Topology-Preserving 3D Image Segmentation Based On Hyperelastic Regularization

Tooth morphometry using quasi-conformal theory

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