Quartz crystal microbalance biosensor for label-free MDA MB 231 cancer cell detection via notch-4 receptor

Bakhshpour, Monireh; Pişkin, A. Kevser; Yavuz, Handan; Deni̇zli̇, Adil

doi:10.1016/j.talanta.2019.06.060

Cited by 65 publications

(22 citation statements)

References 39 publications

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“…The sensing needs isolation equipment that minimizes any hindrance effects because of the high sensitivity to environmental circumstances. These nanosensors have been used in a wide variety of applications to identify targets [58,59]. Thermal nanosensors exploit the fundamental property of biological reactions, such as absorption or evolution of heat.…”

Section: Fundamental Of Nanosensorsmentioning

confidence: 99%

Virus detection using nanosensors

Saylan

Deni̇zli̇

2020

Nanosensors for Smart Cities

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Section: Fundamental Of Nanosensorsmentioning

confidence: 99%

Virus detection using nanosensors

Saylan

Deni̇zli̇

2020

Nanosensors for Smart Cities

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“…They applied the MDA MB 231 cells in different amounts (50–300 cells/ml) to the biosensor and recorded the resonance frequency values. They also tested the sensitivity of the biosensor by selective adsorption of L929 mouse fibroblast cells (Bakhshpour et al, 2019). Kartal et al fabricated a piezoelectric medical biosensor for insulin detection in aqueous and artificial plasma solutions.…”

Section: Recent Studies Of Medical Biosensorsmentioning

confidence: 99%

Recent advances of medical biosensors for clinical applications

2020

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The growing requirements for sensing of biomolecules need the development of sensitive, selective, precise, fast and easy-to-use innovative analytical tools for clinical applications Thaler & Luppa, 2019). Quantitative measurements of biomolecules are generally carried out by conventional methods including spectroscopic and chromatographic techniques for extraction, separation and detection Karami et al., 2020;Liu et al., 2019). These conventional techniques are sensitive; however, they require complicated and expensive pieces of equipment and also need expert staff and time to operate them with sample preparation (Eivazzadeh-Keihan et al., 2019;Soler et al., 2020). It is hard to achieve real-time detection of biomolecules by these techniques.New tools with superior sensing capabilities and high spatial localization are urgently needed for especially clinical applications (Rico-Yuste & Carrasco, 2019). The development of biosensors and also powerful, automated and cost-effective diagnostic platforms for the fast and real-time detection of biomolecules have been struggling by researchers Samson et al., 2020;Wang et al., 2020). The scientists from all over the world combine chemistry, biology, physics, electronics, material science, biotechnology and nanotechnology to follow recent developments due to their specific properties of sensing abilities (

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“…In recent years, various biosensors have been reported for determination of foodborne bacteria, such as electrochemical [1,2], quartz crystal microbalance [3,4] and surface plasmon resonance [5,6], etc. They have attracted great attention because of their simple operation, short time, miniaturized size, and high sensitivity.…”

Section: Introductionmentioning

confidence: 99%

“…After the complexes were captured in the separation chamber using the external magnetic field, GSH was finally injected into the chamber to decompose the MnO 2 NFs into Mn 2+ for releasing the QDs, whose fluorescent intensity was measured by the optical detector to determine the amount of the Salmonella cells. In recent years, various biosensors have been reported for determination of foodborne bacteria, such as electrochemical [1,2], quartz crystal microbalance [3,4] and surface plasmon resonance [5,6], etc. They have attracted great attention because of their simple operation, short time, miniaturized size, and high sensitivity.…”

Section: Introductionmentioning

confidence: 99%

A Microfluidic Biosensor Based on Magnetic Nanoparticle Separation, Quantum Dots Labeling and MnO2 Nanoflower Amplification for Rapid and Sensitive Detection of Salmonella Typhimurium

Huang

et al. 2020

Micromachines

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Screening of foodborne pathogens is an effective way to prevent microbial food poisoning. A microfluidic biosensor was developed for rapid and sensitive detection of Salmonella Typhimurium using quantum dots (QDs) as fluorescent probes for sensor readout and manganese dioxide nanoflowers (MnO2 NFs) and as QDs nanocarriers for signal amplification. Prior to testing, amino-modified MnO2 nanoflowers (MnO2-NH2 NFs) were conjugated with carboxyl-modified QDs through EDC/NHSS method to form MnO2-QD NFs, and MnO2-QD NFs were functionalized with polyclonal antibodies (pAbs) to form MnO2-QD-pAb NFs. First, the mixture of target Salmonella Typhimurium cells and magnetic nanoparticles (MNPs) modified with monoclonal antibodies (mAbs) was injected with MnO2-QD-pAb NFs into a microfluidic chip to form MNP-bacteria-QD-MnO2 complexes. Then, glutathione (GSH) was injected to dissolve MnO2 on the complexes into Mn2+, resulting in the release of QDs. Finally, fluorescent intensity of the released QDs was measured using the fluorescent detector to determine the amount of Salmonella. A linear relationship between fluorescent intensity and bacterial concentration from 1.0 × 102 to 1.0 × 107 CFU/mL was found with a low detection limit of 43 CFU/mL and mean recovery of 99.7% for Salmonella in spiked chicken meats, indicating the feasibility of this biosensor for practical applications.

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Quartz crystal microbalance biosensor for label-free MDA MB 231 cancer cell detection via notch-4 receptor

Cited by 65 publications

References 39 publications

Virus detection using nanosensors

Virus detection using nanosensors

Recent advances of medical biosensors for clinical applications

A Microfluidic Biosensor Based on Magnetic Nanoparticle Separation, Quantum Dots Labeling and MnO2 Nanoflower Amplification for Rapid and Sensitive Detection of Salmonella Typhimurium

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