We calculate the scalar Casimir energy and Casimir force for an R 3 ×N Kaluza-Klein piston setup in which the extra-dimensional space N contains a noncommutative two-dimensional sphere S fz . We study the cases with T d ×S fz and S fz as the extra-dimensional spaces, where T d is the d-dimensional commutative torus, and examine the validity of the results and the regularization obtained in the piston setup in each case. We examine the Casimir energy with one-loop corrections for one piston chamber due to the selfinteracting scalar field in the noncommutative geometry. We compute with some approximations. We compare the obtained results with the results of analogous computations for the Minkowski space-time M D . In conclusion, we discuss the stabilization of the extra-dimensional space in the piston setup.