Non-equilibrium dynamics of many-body systems is important in many branches of science, such as condensed matter, quantum chemistry, and ultracold atoms. Here we report the experimental observation of a phase transition of the quantum coherent dynamics of a 3D many-spin system with dipolar interactions, and determine its critical exponents. Using nuclear magnetic resonance (NMR) on a solid-state system of spins at room-temperature, we quench the interaction Hamiltonian to drive the evolution of the system. The resulting dynamics of the system coherence can be localized or extended, depending on the quench strength. Applying a finite-time scaling analysis to the observed time-evolution of the number of correlated spins, we extract the critical exponents ν ≈ s ≈ 0.42 around the phase transition separating a localized from a delocalized dynamical regime. These results show clearly that such nuclear-spin based quantum simulations can effectively model the non-equilibrium dynamics of complex many-body systems, such as 3D spin-networks with dipolar interactions.The complexity of many-body systems is a long standing problem in physics (1-8). As an example, quantum states of many-body systems can be localized at well defined positions in space or they can be delocalized, depending on parameters like disorder. In their localized regime, such systems may not reach a thermal state but retain information about their initial state on very long timescales (9-17). The role of the topology, dimension, long and short range interactions, and the presence of disorder is very important for the onset of these localization regimes. Much progress was achieved on the numerical and theoretical side, where these phenomena have been predicted under certain conditions. However, experimentally addressing 3D manybody systems in a controlled manner poses severe experimental problems (5,8,14,16). Non-equilibrium dynamics of many-body systems has been investigated to provide complementary information about a large variety of situations but also remains challenging (18-26). Therefore, finding different experimental situations, new approaches and techniques for controlling and observing many-body dynamics can lead to new approaches for studying manybody physics.The recent progress on the experimental control of cold atoms (6, 27, 28), trapped ions (25, 26, 29, 30), Rydberg atoms (31), polar molecules (7, 32) and nitrogen-vacancy centers in diamond (33-36) has led to promising new ways of studying the non-equilibrium dynamics and localization phenomena of many-body systems. In particular a lot of effort is focused on studying many-spin systems with dipolar interactions of the Heisenberg-type (8, 24-26, 31, 32). Here, we use nuclear magnetic resonance (NMR), which provides a natural and versatile approach for coherently controlling large numbers of spins (up to ∼ 7000) in solid state systems, where dipolar interactions are present. NMR techniques allow to quantify the number of spins that are coherently correlated, and allow control of the interact...