Recently, it has been shown that locally randomized measurements can be employed to get partial transpose moments of a density matrix [Elben A., et al. Phys. Rev. Lett. 125, 200501 (2020)].Consequently, two general entanglement detection methods were proposed based on partial transpose moments of a density matrix [Yu X-D., et al. Phys. Rev. Lett. 127, 060504 (2021)]. In this context, a natural question arises that how partial transpose moments are related with entanglement and with well known idea of principal minors. In this work, we analytically demonstrate that for qubit-qubit quantum systems, partial transpose moments can be expressed as simple functions of principal minors. We expect this relation to exist for every bipartite quantum systems. In addition, we have extended the idea of PT-moments for tripartite qubit systems and have shown that PT-moments can only detect the whole range of being NPT for GHZ and W states mixed with white noise.