Quantum optical coherence tomography of a biological sample

Nasr, Magued B.; Goode, Darryl P.; Nguyen, Nam C.; Rong, Guoxin; Yang, Linglu; Reinhard, Björn M.; Saleh, Bahaa E. A.; Teich, Malvin C.

doi:10.1016/j.optcom.2008.11.061

Cited by 72 publications

(41 citation statements)

References 26 publications

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“…35,36 Their unique structural, electronic, and optical properties make gold nanoparticles very attractive for several applications in biotechnology. [37][38][39] Further, gold nanoparticles can provide a natural environment for bimolecular immobilization and facilitate electron transfer of biosensors because of their large surface area, interesting electrochemical properties, and good biocompatibility. [40][41][42] Therefore, magnetic composite Fe 3 O 4 /Au nanoparticles have had more and more applications in areas such as immunoassays, protein immobilization, cell purification, and magnetically controlled transport of anticancer drugs.…”

Section: Introductionmentioning

confidence: 99%

Fe3O4/Au magnetic nanoparticle amplification strategies for ultrasensitive electrochemical immunoassay of alfa-fetoprotein

Gan¹,

Jin²,

Li³

et al. 2011

IJN

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Background The purpose of this study was to devise a novel electrochemical immunosensor for ultrasensitive detection of alfa-fetoprotein based on Fe 3 O 4 /Au nanoparticles as a carrier using a multienzyme amplification strategy. Methods and results Greatly enhanced sensitivity was achieved using bioconjugates containing horseradish peroxidase (HRP) and a secondary antibody (Ab 2 ) linked to Fe 3 O 4 /Au nanoparticles (Fe 3 O 4 /Au-HRP-Ab 2 ) at a high HRP/Ab 2 ratio. After a sandwich immunoreaction, the Fe 3 O 4 /Au-HRP-Ab 2 captured on the electrode surface produced an amplified electrocatalytic response by reduction of enzymatically oxidized hydroquinone in the presence of hydrogen peroxide. The high content of HRP in the Fe 3 O 4 /Au-HRP-Ab 2 could greatly amplify the electrochemical signal. Under optimal conditions, the reduction current increased with increasing alfa-fetoprotein concentration in the sample, and exhibited a dynamic range of 0.005–10 ng/mL with a detection limit of 3 pg/mL. Conclusion The amplified immunoassay developed in this work shows good precision, acceptable stability, and reproducibility, and can be used for detection of alfa-fetoprotein in real samples, so provides a potential alternative tool for detection of protein in the laboratory. Furthermore, this immunosensor could be regenerated by simply using an external magnetic field.

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Section: Introductionmentioning

confidence: 99%

Fe3O4/Au magnetic nanoparticle amplification strategies for ultrasensitive electrochemical immunoassay of alfa-fetoprotein

Gan¹,

Jin²,

Li³

et al. 2011

IJN

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“…However, this quantum limit has never been surpassed in a biological measurement; this includes recent quantum measurements such as quantum coherent intracellular tracking of NV nanodiamonds (10), where no quantum correlations were present between the detected photons. Two previous experiments have applied non-classically correlated photons to biological measurements without achieving quantum enhanced sensitivity; in these, optical coherence tomography was demonstrated within onion skin tissue (11) and protein concentrations measured (9).…”

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confidence: 99%

Biological measurement beyond the quantum limit

Taylor

Janoušek

Daria

et al. 2013

2013 Conference on Lasers &Amp; Electro-Optics Europe &Amp; International Quantum Electronics Conference CLEO EUROPE/IQEC

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Quantum noise places a fundamental limit on the per photon sensitivity attainable in optical measurements. This limit is of particular importance in biological measurements, where the optical power must be constrained to avoid damage to the specimen. By using non-classically correlated light, we demonstrated that the quantum limit can be surpassed in biological measurements. Quantum enhanced microrheology was performed within yeast cells by track-ing naturally occurring lipid granules with sensitivity 2.4 dB beyond the quantum noise limit. The viscoelastic properties of the cytoplasm could thereby be determined with a 64% improved measurement rate. This demonstration paves the way to apply quantum resources broadly in a biological context.Measurements of biological dynamics require low light levels to avoid photochemical intrusion upon biological processes and damaging effects on the specimen (1, 2). With this con-1

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“…By replacing the branching waveguide at the device output with a diffraction grating, prism, or polarizing beam splitter (for Type-II), we can obtain binary modal entanglement. The structure can then be used as a source of binary and continuum entanglement that is expected to be useful for applications such as quantum imaging [29][30][31], quantum cryptography [32], quantum teleportation [33], and quantum information [34]. We note that this waveguide configuration is compatible with integrated optics, which can facilitate its incorporation into a practical system.…”

Section: Features Of Modal Entanglementmentioning

confidence: 99%

Modal, Spectral, and Polarization Entanglement in Guided- Wave Parametric Down-Conversion

Saleh

Teich

2009

Frontiers in Optics 2009/Laser Science XXV/Fall 2009 OSA Optics &Amp; Photonics Technical Digest

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We examine the modal, spectral, and polarization entanglement properties of photon pairs generated in a nonlinear, periodically poled, two-mode waveguide (1-D planar or 2-D circular) via nondegenerate spontaneous parametric down-conversion. Any of the possible degrees of freedommode number, frequency, or polarization -can be used to distinguish the down-converted photons while the others serve as attributes of entanglement. Distinguishing the down-converted photons based on their mode numbers enables us to efficiently generate spectral or polarization entanglement that is either narrowband or broadband. On the other hand, when the generated photons are distinguished by their frequencies in a Type-0 process, modal entanglement turns out to be an efficient alternative to polarization entanglement. Moreover, modal entanglement in Type-II down-conversion may be used to generate a doubly entangled state in frequency and polarization.

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Quantum optical coherence tomography of a biological sample

Cited by 72 publications

References 26 publications

Fe3O4/Au magnetic nanoparticle amplification strategies for ultrasensitive electrochemical immunoassay of alfa-fetoprotein

Fe3O4/Au magnetic nanoparticle amplification strategies for ultrasensitive electrochemical immunoassay of alfa-fetoprotein

Biological measurement beyond the quantum limit

Modal, Spectral, and Polarization Entanglement in Guided- Wave Parametric Down-Conversion

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