Abstract:As weak acids or bases, in solution, drug molecules are
in either
their ionized or nonionized states. A high degree of ionization is
essential for good water solubility of a drug molecule and is required
for drug–receptor interactions, whereas the nonionized form
improves a drug’s lipophilicity, allowing the ligand to cross
the cell membrane. The penetration of a drug ligand through cell membranes
is mainly governed by the pK
a of the drug
molecule and the membrane environment. In this study, with the aim
of p… Show more
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