We report on a two-photon interference experiment in a quantum relay configuration using two picosecond regime periodically poled lithium niobate (PPLN) waveguide based sources emitting paired photons at 1550 nm. The results show that the picosecond regime associated with a guided-wave scheme should have important repercussions for quantum relay implementations in real conditions, essential for improving both the working distance and the efficiency of quantum cryptography and networking systems. In contrast to already reported regimes, namely, femtosecond and CW, it allows achieving a 99% net visibility two-photon interference while maintaining a high effective photon pair rate using only standard telecom components and detectors.For the realization of quantum networks, interference between photons produced by independent sources is necessary. Photon coalescence (or two-photon interference) lies at the heart of quantum operations and is seen as a first step toward achieving both teleportation [1] and entanglement swapping [2][3][4][5][6][7]. This effect has been extensively studied theoretically [8,9] and experimentally, initially based on two photons coming from a single down conversion source and therefore sharing a common past [10][11][12]. However, experiments involving truly independent photons represent an important challenge for achieving longer quantum links by means of quantum relays [13]. In this frame, it has been demonstrated theoretically that a two-photon interference net visibility of at least 95% is required for practical implementations using currently available photon pair sources and multimode quantum memories [14]. Reaching such a high visibility therefore appears to be a hard task since a perfect synchronization between independent sources is necessary to prevent any kind of distinguishability between the interfering photons. Several papers focusing on the synchronization issue have demonstrated that entanglement swapping with fully independent sources is in principle feasible in the femtosecond [3,4] and CW [5,7] regimes. Unfortunately, beyond the fundamental interest, the reported interference visibilities remain either far from 95% or show very low overall photon pair rate. For instance, the best visibility reported so far in the femtosecond regime has been obtained by compensating the synchronization-induced temporal distinguishability by dramatically increasing the photons coherence time up to a few picoseconds at the expense of the overall brightness [4]. Since laser cavities can easily be synchronized to sub-picosecond accuracy [15,16], the study of the picosecond regime [6,17], its associated filter bandwidths, and the type of photon pair generators, becomes of prime interest to ensure simultaneously a high degree of indistinguishability and a high overall brightness.Here, we demonstrate that to achieve this, the picosecond regime should provide an efficient trade-off enabling near-* sebastien.tanzilli@unice.fr perfect two-photon interference and high effective photon pair rates, when...