The connection between real-time quantum field theory (RTQFT) [see, e.g., A. Kamenev and A. Levchenko, Advances in Physics 58 (2009) 197] and phase-space techniques [E. Wolf and L. Mandel, Optical Coherence and Quantum Optics (Cambridge, 1995)] is investigated. The Keldysh rotation that forms the basis of RTQFT is shown to be a phase-space mapping of the quantum system based on the symmetric (Weyl) ordering. Following this observation, we define generalised Keldysh rotations based on the class of operator orderings introduced by Cahill and Glauber [Phys. Rev. 177 (1969) Furthermore, we argue that response transformation is especially suited for RTQFT formulation of spatial, in particular, relativistic, problems, because it extends cancellation of zero-point fluctuations, characteristic of the normal ordering, to interacting fields. As an example, we consider quantised electromagnetic field in the Dirac sea. In the time-normally-ordered representation, dynamics of the field looks essentially classical (fields radiated by currents), without any contribution from zero-point fluctuations. For comparison, we calculate zero-point fluctuations of the interacting electromagnetic field under orderings other than time-normal. The resulting expression is physically inconsistent: it does not obey the Lorentz condition, nor Maxwell's equations.