Quantum Dots with a Paramagnetic Coating as a Bimodal Molecular Imaging Probe

Mulder, Willem J. M.; Koole, Rolf; Brandwijk, Ricardo; Storm, Gert; Chin, P.; Strijkers, Gustav J.; Donegá, Celso de Mello; Nicolay, Klaas; Griffioen, Arjan W.

doi:10.1021/nl051935m

Cited by 444 publications

(380 citation statements)

References 34 publications

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“…Common examples include fluorescent dyes that are quenched by gold nanoparticles (Dulkeith et al 2002(Dulkeith et al , 2005 or that can be excited by fluorescence resonant energy transfer via a quantum dot serving as donor (Funston et al 2008;Liu et al 2008), for instance for biosensors. Other functions include paramagnetic ligand molecules (Mulder et al 2006a) or chelator molecules for radionuclides (Schipper et al 2007;Shokeen et al 2008).…”

Section: (D) Fluorescent Dyes and Other Functions Multi-functional Pmentioning

confidence: 99%

Surface modification, functionalization and bioconjugation of colloidal inorganic nanoparticles

Sperling

Parak

2010

Phil. Trans. R. Soc. A.

1,369

1,075

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Inorganic colloidal nanoparticles are very small, nanoscale objects with inorganic cores that are dispersed in a solvent. Depending on the material they consist of, nanoparticles can possess a number of different properties such as high electron density and strong optical absorption (e.g. metal particles, in particular Au), photoluminescence in the form of fluorescence (semiconductor quantum dots, e.g. CdSe or CdTe) or phosphorescence (doped oxide materials, e.g. Y 2 O 3 ), or magnetic moment (e.g. iron oxide or cobalt nanoparticles). Prerequisite for every possible application is the proper surface functionalization of such nanoparticles, which determines their interaction with the environment. These interactions ultimately affect the colloidal stability of the particles, and may yield to a controlled assembly or to the delivery of nanoparticles to a target, e.g. by appropriate functional molecules on the particle surface. This work aims to review different strategies of surface modification and functionalization of inorganic colloidal nanoparticles with a special focus on the material systems gold and semiconductor nanoparticles, such as CdSe/ZnS. However, the discussed strategies are often of general nature and apply in the same way to nanoparticles of other materials.

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Section: (D) Fluorescent Dyes and Other Functions Multi-functional Pmentioning

confidence: 99%

Surface modification, functionalization and bioconjugation of colloidal inorganic nanoparticles

Sperling

Parak

2010

Phil. Trans. R. Soc. A.

1,369

1,075

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“…[1][2][3][4][5][6][7][8][9] To date, several types of hybrid nanosystems containing multiple different types of nanoparticles have been developed that allow multimodal imaging. For example, formulations containing quantum dots (QD) and magnetic iron oxide nanoparticles (MN) provide a means to perform simultaneous fluorescent optical imaging and magnetic resonance imaging (MRI).…”

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confidence: 99%

Micellar Hybrid Nanoparticles for Simultaneous Magnetofluorescent Imaging and Drug Delivery

et al. 2008

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Keywords biological imaging; cancer; drug delivery; magnetic nanoparticles; micelle; quantum dots Multifunctional nanoparticles have the potential to integrate therapeutic and diagnostic functions into a single nanodevice. [1][2][3][4][5][6][7][8][9] To date, several types of hybrid nanosystems containing multiple different types of nanoparticles have been developed that allow multimodal imaging. For example, formulations containing quantum dots (QD) and magnetic iron oxide nanoparticles (MN) provide a means to perform simultaneous fluorescent optical imaging and magnetic resonance imaging (MRI). [10][11][12][13][14][15] While these nanocomposites have been used for in vitro magnetic cell separation and in vitro cell targeting, there are limited in vivo studies, particularly for cancer imaging and therapy, due to poor stability or short systemic circulation times generally observed for these more complicated nanostructures. [16,17] Herein, we introduce long-circulating, micellar hybrid nanoparticles (MHN) that contain MN, QD, and the anti-cancer drug doxorubicin (DOX) within a single

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“…Recently multi-modal imaging probes that can expand the capabilities and functionalities of single nanoparticles have attracted increasing interest for various biomedical applications [40][41][42][43][44]. To demonstrate the potential applications of our magneticoptical hybrid nanoparticles for cancer cell targeting and imaging, the IONP-QD hybrid nanoparticles coated with functionalized PEO-b-PγMPS copolymer were conjugated with the thiolated small peptide cyclo(Arg-Gly-Asp-D-Phe-Cys) (RGD-SH) using the same method reported previously to target tumor integrin α v β 3 [20].…”

Section: Resultsmentioning

confidence: 99%

Preparation and control of the formation of single core and clustered nanoparticles for biomedical applications using a versatile amphiphilic diblock copolymer

et al. 2010

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We report the application of a versatile diblock copolymer, poly(ethylene oxide)-b-poly(γ-methacryloxypropyl trimethoxysilane) (PEO-b-PγMPS), to prepare nanocrystals such as iron oxide nanoparticles or quantum dots, with either a single core or multi-core cluster, for biomedical applications. This amphiphilic copolymer comprises both a hydrophilic PEO segment and a hydrophobic segment with a "surface anchoring moiety" (the silane group) which can interact effectively with the hydrophobic nanocrystals through ligand exchange. One of the unique features of this work is that we can control the formation of either single core nanoparticles or multi-core nanoclusters by simply varying the conditions of ligand exchange and aging of the mixture of block copolymer and nanoparticles without needing to change the copolymer. The morphologies of the resulting single core nanoparticles or multi-core nanoclusters were confirmed by dynamic light scattering and transmission electron microscopy. The clustered nanoparticles exhibit enhanced physicochemical properties that are beyond those expected from a simple accumulation of individual nanoparticles. Additionally, the hybrid nanoparticles containing both magnetic iron oxide nanoparticles and optical quantum dots obtained using our strategy provide have combined magnetic and optical functionalities that allow for potential new and expanded biomedical applications, as demonstrated by their use for magnetic resonance imaging and biomarker-targeted cell imaging.

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Quantum Dots with a Paramagnetic Coating as a Bimodal Molecular Imaging Probe

Cited by 444 publications

References 34 publications

Surface modification, functionalization and bioconjugation of colloidal inorganic nanoparticles

Surface modification, functionalization and bioconjugation of colloidal inorganic nanoparticles

Micellar Hybrid Nanoparticles for Simultaneous Magnetofluorescent Imaging and Drug Delivery

Preparation and control of the formation of single core and clustered nanoparticles for biomedical applications using a versatile amphiphilic diblock copolymer

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