Quantum dots in imaging, drug delivery and sensor applications

Matea, Cristian; Mocan, Teodora; Tabaran, Flaviu; Pop, Teodora; Moşteanu, Ofelia; Puia, Cosmin; Iancu, Cornel; Mocan, Lucian

doi:10.2147/ijn.s138624

Cited by 507 publications

(252 citation statements)

References 58 publications

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“…Magnetic nanoparticles are easily and scalably manufactured, and they can be detected by MRI for tracking or diagnostic purposes as well as moved toward target cells using a magnetic field . Quantum dots (QDs) are an interesting option as a delivery vehicle with optical properties, as they are designed to be bright, photostable imaging agents and are normally of small size amenable to in vivo trafficking and cellular uptake . As with other inorganic nanoparticles mentioned here, many of these are generally used in combination with other gene delivery materials, such as coatings of PEI, PEG, and other polymers to allow binding and other capabilities required for gene delivery.…”

Section: Nanomaterials For Combinatorial Nucleic Acid Deliverymentioning

confidence: 99%

Cancer‐Targeting Nanoparticles for Combinatorial Nucleic Acid Delivery

2019

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Nucleic acids are a promising type of therapeutic for the treatment of a wide range of conditions, including cancer, but they also pose many delivery challenges. For efficient and safe delivery to cancer cells, nucleic acids must generally be packaged into a vehicle, such as a nanoparticle, that will allow them to be taken up by the target cells and then released in the appropriate cellular compartment to function. As with other types of therapeutics, delivery vehicles for nucleic acids must also be designed to avoid unwanted side effects; thus, the ability of such carriers to target their cargo to cancer cells is crucial. Classes of nucleic acids, hurdles that must be overcome for effective intracellular delivery, types of nonviral nanomaterials used as delivery vehicles, and the different strategies that can be employed to target nucleic acid delivery specifically to tumor cells are discussed. Additonally, nanoparticle designs that facilitate multiplexed delivery of combinations of nucleic acids are reviewed.

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Section: Nanomaterials For Combinatorial Nucleic Acid Deliverymentioning

confidence: 99%

Cancer‐Targeting Nanoparticles for Combinatorial Nucleic Acid Delivery

2019

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“…Highest power conversion efficiency of CdTe solar cells is reported to be as high as ∼20‐22 %, which is probably the highest among all QD based light harvesting devices . Apart from the device applications, in biology and biomedical fields QDs have shown great potential in numerous applications like imaging, sensing, therapy, drug delivery and so on . Exploitation of the CdTe QD fluorescence in biology is extensive for supramolecular interaction study.…”

Section: Introductionmentioning

confidence: 99%

Study of Interfacial Charge Transfer from an Electron Rich Organic Molecule to CdTe Quantum Dot by using Stern‐Volmer and Stochastic Kinetic Models

et al. 2020

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Photoinduced electron transfer (PET) from N‐methylaniline (NMA) to a photoexcited CdTe quantum dot (QD*) is studied in toluene. The PET mechanism at low to moderate quencher (NMA) concentrations (<0.08 M) remains mostly collisional with some contributions from QD‐NMA complex formation. However, at high quencher concentrations (>0.10 M), QDs form larger numbers of static complexes with NMA molecules leading to a steep positive deviation in the steady‐state Stern–Volmer curves. An isothermal titration calorimetry (ITC) study confirms the formation of QD‐NMA complexes (K∼150 M−1) at high quencher concentrations. Fitting our experimental data using a stochastic kinetic model indicates that the number of NMA molecules attached per QD at highest NMA concentration (∼0.16 M) used in this study decreases from ∼0.76 to ∼0.47 with reducing the QD size from ∼5.2 nm to ∼3.2 nm. However, the PET rate increases with decreasing QD size, which is commensurate with the observation that the chemical driving force (ΔG) increases with decreasing the QD particle size. We have analyzed the PET kinetics mainly by using Stern‐Volmer fittings. However, in some cases Tachiya's stochastic kinetic model is used for stoichiometric analysis, which seems to be useful only at high quencher concentrations. The measured PET rate coefficients in all the cases are found to be at least an order of magnitude lower when compared to the diffusion‐controlled rate of the reaction medium.

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“…The nano-sized semiconductor crystals commonly known as quantum dots (QDs) with their exceptional electronic and optical properties are highly appreciated. 93,94 Specifically intensive fluorescence, high quantum yield, size-tunable light emission, appreciable chemical and photo-stability have revolutionized the concept of nano-based sensing or diagnostics. General elemental composition of QDs includes cadmium (Cd), lead (Pb), mercury (Hg) and zinc (Zn).…”

Section: Quantum Dotsmentioning

confidence: 99%

“…But recently developed ternary I-III-VI QDs contain elements in different form, here "I" represents cupper (Cu) or silver (Ag), "III" represents gadolinium (Ga) or indium (In) and "VI" represents sulfur (S) or selenium (Se). 94 Owing to their extremely small size ranging from 2 to 10 nm QDs are well appreciated and used in biomedical sector as they could conveniently cross the BBB in conjugation with a therapeutic molecule. 94,95 Mahajan et al showed that fluorescent quantum rods (QRs) a form of QD in conjugation with transferring, a targeting molecule and HAAT (Highly Active Antiretroviral Therapy) drug Sequinavir could freely cross an in vitro model of BBB.…”

Section: Quantum Dotsmentioning

confidence: 99%

Nano-based approach to combat emerging viral (NIPAH virus) infection

Kerry

Malik

Redda

et al. 2019

Nanomedicine: Nanotechnology, Biology and Medicine

108

107

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Emergence of new virus and their heterogeneity are growing at an alarming rate. Sudden outburst of Nipah virus (NiV) has raised serious question about their instant management using conventional medication and diagnostic measures. A coherent strategy with versatility and comprehensive perspective to confront the rising distress could perhaps be effectuated by implementation of nanotechnology. But in concurrent to resourceful and precise execution of nano-based medication, there is an ultimate need of concrete understanding of the NIV pathogenesis. Moreover, to amplify the effectiveness of nano-based approach in a conquest against NiV, a list of developed nanosystem with antiviral activity is also a prerequisite. Therefore the present review provides a meticulous cognizance of cellular and molecular pathogenesis of NiV. Conventional as well several nano-based diagnosis experimentations against viruses have been discussed. Lastly, potential efficacy of different forms of nano-based systems as convenient means to shield mankind against NiV has also been introduced.

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Quantum dots in imaging, drug delivery and sensor applications

Cited by 507 publications

References 58 publications

Cancer‐Targeting Nanoparticles for Combinatorial Nucleic Acid Delivery

Cancer‐Targeting Nanoparticles for Combinatorial Nucleic Acid Delivery

Study of Interfacial Charge Transfer from an Electron Rich Organic Molecule to CdTe Quantum Dot by using Stern‐Volmer and Stochastic Kinetic Models

Nano-based approach to combat emerging viral (NIPAH virus) infection

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