Quantum Dots based on Indium Phosphide (InP): the Effect of Chemical Modifications of the Organic Shell on Interaction with Cultured Cells of Various Origins

Литвинов, И. К.; Belyaeva, T. N.; Салова, А.В.; Aksenov, N. D.; Leontieva, E. A.; Орлова, А. О.; Корнилова, Е. С.

doi:10.1134/s1990519x18020050

Cited by 13 publications

(5 citation statements)

References 39 publications

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“…The widespread approach to the study of the PL properties of QDs associated with cells by steady-state luminescence methods can give an erroneous result, since the QD PL intensity can decrease for many reasons, including QD aggregation and the emergence of new non-radiative relaxation channels. We also showed earlier that the pH of the medium also affects the PL intensity of QDs [ 63 , 64 ]. Steady-state methods cannot answer what exactly the reason for the quenching of QD luminescence in cells is.…”

Section: Resultsmentioning

confidence: 65%

Time- and Spectrally-Resolved Photoluminescence Study of Alloyed CdxZn1−xSeyS1−y/ZnS Quantum Dots and Their Nanocomposites with SPIONs in Living Cells

Matiushkina

Литвинов

Bazhenova

et al. 2022

IJMS

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Magnetic-luminescent composites based on semiconductor quantum dots (QDs) and superparamagnetic iron oxide nanoparticles (SPIONs) can serve as a platform combining visualization and therapy. Here, we report the construction of QD-SPION nanocomposites based on synthesized SPIONs and alloyed QDs (CdxZn1−xSeyS1−y)/ZnS solubilized with L-cysteine molecules. The study of the spectral-luminescence characteristics, the kinetics of luminescence decay show the composite’s stability in a solution. After incubation with HeLa cells, QDs, SPIONs, and their composites form clusters on the cell surface and associate with endosomes inside the cells. Component-wise analysis of the photoluminescence decay of cell-associated QDs/SPIONs provides information about their localization and aggregate status.

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Section: Resultsmentioning

confidence: 65%

Time- and Spectrally-Resolved Photoluminescence Study of Alloyed CdxZn1−xSeyS1−y/ZnS Quantum Dots and Their Nanocomposites with SPIONs in Living Cells

Matiushkina

Литвинов

Bazhenova

et al. 2022

IJMS

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“…NCs with cores of heavy metal compounds, such as CdSe, CdTe, and PbS, were initially the most widespread due to their easy synthesis and unique optical properties [ 125 , 126 ]. However, the current trend is to use the nontoxic cadmium-free and lead-free fluorescent NCs made of silicon [ 127 ], carbon [ 128 ], graphene [ 129 ], ZnS [ 130 ], CuInS 2 [ 131 ], AgInS 2 [ 132 ], or InP [ 133 ].…”

Section: Fluorescent Labels For Multiplexed 3d Imagingmentioning

confidence: 99%

Nontoxic Fluorescent Nanoprobes for Multiplexed Detection and 3D Imaging of Tumor Markers in Breast Cancer

et al. 2023

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Multiplexed fluorescent immunohistochemical analysis of breast cancer (BC) markers and high-resolution 3D immunofluorescence imaging of the tumor and its microenvironment not only facilitate making the disease prognosis and selecting effective anticancer therapy (including photodynamic therapy), but also provides information on signaling and metabolic mechanisms of carcinogenesis and helps in the search for new therapeutic targets and drugs. The characteristics of imaging nanoprobe efficiency, such as sensitivity, target affinity, depth of tissue penetration, and photostability, are determined by the properties of their components, fluorophores and capture molecules, and by the method of their conjugation. Regarding individual nanoprobe components, fluorescent nanocrystals (NCs) are widely used for optical imaging in vitro and in vivo, and single-domain antibodies (sdAbs) are well established as highly specific capture molecules in diagnostic and therapeutic applications. Moreover, the technologies of obtaining functionally active sdAb–NC conjugates with the highest possible avidity, with all sdAb molecules bound to the NC in a strictly oriented manner, provide 3D-imaging nanoprobes with strong comparative advantages. This review is aimed at highlighting the importance of an integrated approach to BC diagnosis, including the detection of biomarkers of the tumor and its microenvironment, as well as the need for their quantitative profiling and imaging of their mutual location, using advanced approaches to 3D detection in thick tissue sections. The existing approaches to 3D imaging of tumors and their microenvironment using fluorescent NCs are described, and the main comparative advantages and disadvantages of nontoxic fluorescent sdAb–NC conjugates as nanoprobes for multiplexed detection and 3D imaging of BC markers are discussed.

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“…While highly dispersible in common organic solvents, InP suffers from a lack of colloidal stability in aqueous media. To mitigate this, b a a variety of hydrophilic capping ligands have been investigated, including mercaptosuccinic acid and polyethylene glycol-functionalized carboxylic acids and amines (71,72). To not only increase the biocompatibility of shelled InP nanocrystals but also increase the efficacy of the material as a biological probe, penicillamine has been attached as the capping ligand (73).…”

Section: 33mentioning

confidence: 99%

Surface Chemistry of Metal Phosphide Nanocrystals

Eagle

Rivera-Maldonado

Cossairt

2021

Annu. Rev. Mater. Res.

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Semiconducting and metallic metal phosphide nanocrystals have gained increased attention in the materials science and engineering community due to their demonstrated and theoretical promise in both emissive and catalytic applications. Central to realizing the full potential of nanoscale metal phosphides is a thorough understanding of their surfaces and how surface chemistry impacts their function. In this review, we document what is known about the surface chemistry of metal phosphide nanocrystals, including both as synthesized and postsynthetically modified species, and draw a connection between surface chemistry and functional properties. This survey is intended to provide a comprehensive view of metal phosphide nanocrystal surface chemistry and how it differs across the families of phosphide materials. A clear distinction emerges between the semiconducting and metallic phosphides from both a synthetic and applied standpoint. We seek to expose key knowledge gaps and targets for further scientific and technological development. Expected final online publication date for the Annual Review of Materials Science, Volume 51 is August 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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Quantum Dots based on Indium Phosphide (InP): the Effect of Chemical Modifications of the Organic Shell on Interaction with Cultured Cells of Various Origins

Cited by 13 publications

References 39 publications

Time- and Spectrally-Resolved Photoluminescence Study of Alloyed CdxZn1−xSeyS1−y/ZnS Quantum Dots and Their Nanocomposites with SPIONs in Living Cells

Time- and Spectrally-Resolved Photoluminescence Study of Alloyed CdxZn1−xSeyS1−y/ZnS Quantum Dots and Their Nanocomposites with SPIONs in Living Cells

Nontoxic Fluorescent Nanoprobes for Multiplexed Detection and 3D Imaging of Tumor Markers in Breast Cancer

Surface Chemistry of Metal Phosphide Nanocrystals

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