Quantum Dot Thermometry Evaluation of Geometry Dependent Heating Efficiency in Gold Nanoparticles

Abstract

Quantum dot based thermometry, in combination with double beam confocal microscopy, was used to investigate the absorption/heating efficiency of gold nanoparticles with different morphologies (nanorods, nanocages, nanoshells, and nanostars), all of them with an intense localized surface plasmon resonance within the first biological window, at around 808 nm. The heating efficiency was found to be strongly dependent on the geometry of the nanostructure, with the largest values found for gold nanorods and long-edge gold nanostars, both of them with heating efficiencies close to 100%. Gold nanorods and nanocages were found to have the largest absorption cross section per unit mass among all the studied geometries, emerging as optimum photothermal agents with minimum metal loading for biosystems.

Plasmonic Photothermal Therapy in Third and Fourth Biological Windows

“…However, cellular uptake for NPs that are smaller than 100 nm is well documented for PPT applications in NIR-I & II [15,14,3,1,2]. In NIR-III & IV even the smallest contour nanobars exceed 100 nm (Fig.…”

“…Among various materials, gold is the dominant choice for NPs especially in biological applications due to its chemical inertness, biocompatibility and ability to support localized surface plasmon resonance(LSPR). Several studies indicate that a rodlike design is the most efficient geometry for PPT applications [1,2,3].…”

Ion-Mediated Aggregation of Gold Nanoparticles for Light-Induced Heating

“…Therefore, the increase of temperature is compared within the different values of ionic strength. Additional considerations in further studies comprising plasmonic nanoparticles of different sizes and shapes should be included [20].…”

In vitro biomechanical properties, fluorescence imaging, surface-enhanced Raman spectroscopy, and photothermal therapy evaluation of luminescent functionalized CaMoO4:Eu@Au hybrid nanorods on human lung adenocarcinoma epithelial cells

“…It is well known that pure Au nanorods and nanostars exhibit strong PTT activity (100%). [37] Also, GNRs shows high absorption cross section as compared to carbon nanotubes, quantum dots and organic dyes. [38] Self-assembled WO 3−x hierarchical nanostructures ranging from 700 to 1400 nm were prepared with η 28% by Hu et al [39], and the same research group prepared CuS NPs with η 38%.…”