Quantum dot-containing polymer particles with thermosensitive fluorescence

Förster (or fluorescence) resonance energy transfer amongst semiconductor quantum dots (QDs) is reviewed, with particular interest in biosensing applications. The unique optical properties of QDs provide certain advantages and also specific challenges with regards to sensor design, compared to other FRET systems. The brightness and photostability of QDs make them attractive for highly sensitive sensing and long-term, repetitive imaging applications, respectively, but the overlapping donor and acceptor excitation signals that arise when QDs serve as both the donor and acceptor lead to high background signals from direct excitation of the acceptor. The fundamentals of FRET within a nominally homogeneous QD population as well as energy transfer between two distinct colors of QDs are discussed. Examples of successful sensors are highlighted, as is cascading FRET, which can be used for solar harvesting.

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“…Interdot spacing can be modified by embedding QDs into a support matrix [ 79 , 95 , 96 ]. Chen et al .…”

Section: Qd-qd Fretmentioning

confidence: 99%

Förster Resonance Energy Transfer between Quantum Dot Donors and Quantum Dot Acceptors

Chou

Dennis

2015

Sensors

250

242

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“…Similarly, directed coupling of an anticreatine kinase antibody in a commercial EIA system resulted in a shorter assay time and improved assay performance over use ofthe uncomplexed antibody [213]. Antibody fragments have even been conjugated to QD-containing polyacrolein and poly(acrolein-costyrene) particles by reaction with surface aldehyde groups [214].In the case of whole immunoglobulins, these were usedin vitro in a simple and rapid agglutination-based detection of the pathogenic bacterium Yersinia pestis, while similarly conjugated anti-HER2 scFvs proved suitable for use in multipoint detection of cells expressing the cancer marker [215].…”

Section: In Vitro Applicationsmentioning

confidence: 99%

Polymer-antibody fragment conjugates for biomedical applications

Srivastava

O'Connor

Pandit

et al. 2014

Progress in Polymer Science

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“…There is also significant progress in the field of nanosensorics [8][9][10][11]. For example, in [8], by adding trace amounts of QDs to the outer surface of an organo-modified composite, a QDs-bihydroxide type structure was developed capable to react to nitrite by increasing the intensity of chemiluminescence.…”

Section: Physbiosymp17mentioning

confidence: 99%