One of the main quests in quantum metrology, and quantum parameter estimation in general, is to find out the highest achievable precision with given resources and design schemes to attain it. In this article we present a general framework for quantum parameter estimation and provide systematic methods for computing the ultimate precision limit, which is more general and efficient than conventional methods.npj Quantum Information (2017) 3:14 ; doi:10.1038/s41534-017-0014-6 INTRODUCTION A pivotal task in science and technology is to identify the highest achievable precision in measurement and estimation and design schemes to reach it. Quantum metrology, which exploits quantum mechanical effects such as entanglement, can achieve better precision than classical schemes and has found wide applications in quantum sensing, gravitational wave detection, quantumenhanced reading of digital memory, quantum imaging, atomic clock synchronization, etc.; 1-11 this has gained increasing attention in recent years.