Quantomo: Validation of a Computer-Assisted Methodology for the Volumetric Analysis of Intracerebral Haemorrhage

Kosior, Jayme C.; Idris, Sherif; Dowlatshahi, Dar; Alzawahmah, Mohamed; Eesa, Muneer; Sharma, Payal; Tymchuk, Sarah; Hill, Michael D.; Aviv, Richard I.; Frayne, Richard; Demchuk, Andrew M.; investigators, Sunnybrook Cta Ich study

doi:10.1111/j.1747-4949.2010.00579.x

Cited by 80 publications

(56 citation statements)

References 11 publications

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“…For adults who underwent brain imaging (and were not diagnosed at autopsy), we calculated hematoma volume using the first CT brain scan after the adult's presentation with ICH using Quantomo computerized planimetry software (Cybertrial Inc, Calgary, Canada), which has been shown to have greater reliability for quantifying ICH volume in comparison with the ABC/2 method. 64,65 We assessed the performance of the ICH score 8 at distinguishing between those who survive and those who do not 1 year after an ICH by calculating the area under a receiver operator characteristic curve using the values of the ICH score obtained for each participant.…”

Section: Discussionmentioning

confidence: 99%

Influence of Intracerebral Hemorrhage Location on Incidence, Characteristics, and Outcome

Samarasekera

Fonville

Lerpiniere

et al. 2015

Stroke

146

106

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Background and Purpose-The characteristics of intracerebral hemorrhage (ICH) may vary by ICH location because of differences in the distribution of underlying cerebral small vessel diseases. Therefore, we investigated the incidence, characteristics, and outcome of lobar and nonlobar ICH. Methods-In a population-based, prospective inception cohort study of ICH, we used multiple overlapping sources of case ascertainment and follow-up to identify and validate ICH diagnoses in 2010 to 2011 in an adult population of 695 335. Results-There were 128 participants with first-ever primary ICH. The overall incidence of lobar ICH was similar to nonlobar ICH (9.

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Section: Discussionmentioning

confidence: 99%

Influence of Intracerebral Hemorrhage Location on Incidence, Characteristics, and Outcome

Samarasekera

Fonville

Lerpiniere

et al. 2015

Stroke

146

106

View full text Add to dashboard Cite

show abstract

“…Automation enabled our analyses to be performed in Ͻ5 seconds per patient, excluding region-ofinterest generation, but this function can also be fully automated. 35 Leave-one-out cross-validation was used to test the predictive models, serially excluding each patient in the dataset from analysis, thereby establishing a validation dataset and avoiding overestimation of model significance. Furthermore, this technique examines the full range of attenuation information available from each patient's entire ICH, improving the limited "largest section" qualitative approach.…”

Section: Discussionmentioning

confidence: 99%

Quantitative CT Densitometry for Predicting Intracerebral Hemorrhage Growth

Barras¹,

Tress²,

Christensen³

et al. 2013

AJNR Am J Neuroradiol

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“…If magnetic resonance diffusion-weighted imaging was not available, a noncontrast computed tomographic scan (NCCT) was chosen for measurement. An expert (Dr Al-Ajlan) used Quantomo (Cybertrial Inc, Calgary) 6 to delineate infarct and measure post-treatment infarct volumes (in milliliters) while being blinded to all other clinical and imaging information. Manual adjustments to delineate infarct boundaries were performed where necessary.…”

Section: Methodsmentioning

confidence: 99%

Intra-Arterial Therapy and Post-Treatment Infarct Volumes

Al-Ajlan

Goyal

Demchuk

et al. 2016

Stroke

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Background and Purpose-The goal of reperfusion therapy in acute ischemic stroke is to limit brain infarction. The objective of this study was to investigate whether the beneficial effect of endovascular treatment on functional outcome could be explained by a reduction in post-treatment infarct volume. Methods-The Endovascular Treatment for Small Core and Anterior Circulation Proximal Occlusion With Emphasis onMinimizing CT to Recanalization Times (ESCAPE) trial was a multicenter randomized open-label trial with blinded outcome evaluation. Among 315 enrolled subjects (endovascular treatment n=165; control n=150), 314 subject's infarct volumes at 24 to 48 hours on magnetic resonance imaging (n=254) or computed tomography (n=60) were measured. Posttreatment infarct volumes were compared by treatment assignment and recanalization/reperfusion status. Appropriate statistical models were used to assess relationship between baseline clinical and imaging variables, post-treatment infarct volume, and functional status at 90 days (modified Rankin Scale). Results-Median post-treatment infarct volume in all subjects was 21 mL (interquartile range =65 mL), in the intervention arm, 15.5 mL (interquartile range =41.5 mL), and in the control arm, 33.5 mL (interquartile range =84 mL; P<0.01). Baseline National Institute of Health Stroke Scale (P<0.01), site of occlusion (P<0.01), baseline noncontrast computed tomographic scan Alberta Stroke Program Early CT score (ASPECTS) (P<0.01), and recanalization (P<0.01) were independently associated with post-treatment infarct volume, whereas age, sex, treatment type, intravenous alteplase, and time from onset to randomization were not (P>0.05). Post-treatment infarct volume (P<0.01) and delta National Institute of Health Stroke Scale (P<0.01) were independently associated with 90-day modified Rankin Scale, whereas laterality (left versus right) was not. E verything that we think, plan, or do comes from within the human brain. Our language, our arts and culture, the meaning of being human are all products of the human brain. The drugs, devices, and techniques we have developed for acute ischemic stroke therapy are aimed at saving the human brain from death. Clinical trials in ischemic stroke test if these therapies are capable of reducing damage to the brain. Conclusions-TheseAn ability to speak, listen, and understand; to move, walk, or run; to see and interact with the world around us are all examples of brain functions. Clinical trials use ordinal scales like the modified Rankin Scale (mRS), the National Institute of Health Stroke Scale (NIHSS), or the Barthel index to quantify these functions.1-3 Understandably, none of these scales ever capture the entirety of functions and capabilities of the human brain. Therefore, it is important for stroke therapies being tested within clinical trials to also be able to show that they save brain tissue.Using a detailed post hoc analysis of the Endovascular Treatment for Small Core and Anterior Circulation Proximal Occlusion With Emphasis on Minim...

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Quantomo: Validation of a Computer-Assisted Methodology for the Volumetric Analysis of Intracerebral Haemorrhage

Abstract: Quantomo is a computer-assisted methodology that is more reliable for quantifying intracerebral haemorrhage volume as compared with the ABC/2 method.

Cited by 80 publications

References 11 publications

Influence of Intracerebral Hemorrhage Location on Incidence, Characteristics, and Outcome

Influence of Intracerebral Hemorrhage Location on Incidence, Characteristics, and Outcome

Quantitative CT Densitometry for Predicting Intracerebral Hemorrhage Growth

Intra-Arterial Therapy and Post-Treatment Infarct Volumes

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