Quantity and quality of muscle in patients recently diagnosed with colorectal cancer: a comparison with cancer-free controls

Cruz-Fernández, Mayra; Achalandabaso‐Ochoa, Alexander; Gallart-Aragón, Tania; Artacho‐Cordón, Francisco; Cabrerizo-Fernández, María José; Pacce-Bedetti, Nicolás; Cantarero‐Villanueva, Irene

doi:10.1007/s00520-020-05314-2

Cited by 5 publications

(4 citation statements)

References 46 publications

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“…Related to general muscle mass, the skeletal muscle mass index indicated that only the PTG showed moderate sarcopenia, a prevalent problem in patients with cancer because it involves a higher risk of developing immediate postoperative complications and decreased tolerance to chemoradiotherapy because of side effects [ 44 ]. However, in the muscles around the tumor, both the NDG and PTG presented a width reduction (with 13.19% less lumbar multifidus width in the NDG and 17.82% in the PTG) compared with the HMCG, a finding that is consistent with previous findings in patients with CRC [ 15 , 45 ]. This early impact in muscle close to the tumor location could be caused by tumor inflammation-released cytokines [ 46 ].…”

Section: Discussionsupporting

confidence: 91%

Colorectal cancer pain upon diagnosis and after treatment: a cross-sectional comparison with healthy matched controls

López-Garzón

Postigo-Martín

González-Santos

et al. 2022

Support Care Cancer

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Background The current study sought to explore whether cancer pain (CP) already exists in patients at colorectal cancer (CRC) diagnosis before treatment compared with patients with colorectal cancer (CRC) after treatment and a healthy matched control group. The study also sought to examine whether factors related to physical health status could enhance pain processes. Methods An observational cross-sectional study was conducted following the STROBE checklist. Twenty-nine newly diagnosed and forty post-treatment patients with CRC and 40 healthy age/sex-matched controls were included for comparison. Pain, local muscle function, and body composition outcomes were assessed by a physiotherapist with > 3 years of experience. ANCOVA and Kruskal–Wallis tests were performed, with Bonferroni and Dunn-Bonferroni post hoc analyses and Cohen’s d and Hedge’s effect size, as appropriate. Results The analysis detected lower values of pressure pain threshold (PPT) points, the PPT index, and abdominal strength and higher values of self-reported abdominal pain in newly diagnosed patients, with even more marked results observed in the post-treatment patients, where lower lean mass and skeletal muscle index values were also found than those in the healthy matched controls (p < 0.05). In the post-treatment and healthy matched control groups, positive associations were observed between the PPT lumbar dominant side points and abdominal isometric strength and lean mass, and negative associations were observed between the lumbar dominant side points and body fat (p < 0.05). Conclusion Upon diagnosis, patients with CRC already show signs of hyperalgesia and central sensitization and deteriorated physical conditions and body composition, and this state could be aggravated by subsequent treatments.

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Section: Discussionsupporting

confidence: 91%

Colorectal cancer pain upon diagnosis and after treatment: a cross-sectional comparison with healthy matched controls

López-Garzón

Postigo-Martín

González-Santos

et al. 2022

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“…There were significant decreases in muscle mass and trunk muscle mass in female malignant tumor patients compared with healthy subjects. In a previous report, Fernández et al found a significantly lower trunk muscle mass in patients with colorectal malignancies compared with healthy subjects [ 10 ]. Salhi et al reported that trunk muscle mass was already reduced at diagnosis in patients with lung malignancies [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Muscle Mass Between Healthy Subjects and Patients With Malignant Tumors Undergoing Outpatient Treatment

Takaoka¹,

Furuya²,

Maki³

et al. 2023

Cureus

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Background In recent years, advances in the treatment of malignant tumors have improved life expectancy and diversified treatment options. However, maintaining high activities of daily living in patients is essential for appropriately treating the primary disease, and interventions for patients with impaired motor function will lead to improved quality of life. Here, we compared the muscle mass of malignant tumor patients who are visiting bone metastasis outpatient clinics with that of healthy subjects. Methods We compared the muscle mass of 61 malignant tumor patients with an Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2 (mean 66.3 ± 12.0 years; 30 males and 31 females) attending our bone metastasis outpatient clinic since 2018 with that of 315 healthy subjects (mean 65.0 ± 17.7 years; 110 males and 205 females). Body mass index, skeletal muscle mass, and body fat percentage were assessed by bioimpedance analysis, and the skeletal muscle mass index (SMI) was calculated. Results To eliminate age bias in the malignant tumor patients and healthy subjects, 1:1 propensity score matching was performed separately for males and females. There was no significant difference in right upper limb, left upper limb, right lower limb, or left lower limb mass or SMI between the two groups, whereas trunk muscle mass and muscle mass were significantly higher in the healthy females compared with malignant tumor females. Conclusion There was no significant difference in the SMI measured by bioimpedance analysis between the two groups in either males or females, while muscle mass and trunk muscle mass were significantly lower in female malignant tumor patients than in healthy subjects. These results suggest that even malignant tumor patients whose performance status was maintained enough to allow outpatient visits still had impaired motor function.

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“…The lack of sufficiently strong deep muscles can cause back pain, diastasis recti (abdominal separation) and weaken the pelvic floor muscles. Adhesions can also cause defecation problems, urinary incontinence, organ prolapse, hernias and digestive problems [ 21 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

“…Research shows that, following treatment for colorectal cancer, the patients also show a weakened body core strength [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

The Impact of Surgical Techniques in Patients with Rectal Cancer on Spine Mobility and Abdominal Muscle Strength—A Prospective Study

Głowacka-Mrotek

Jankowski

Skonieczny

et al. 2022

Cancers

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The aim of this non-randomized study was to evaluate the impact of spine joint mobility and chest mobility on inhalation and exhalation, and to assess the abdominal muscle strength in patients undergoing surgery for colorectal cancer with one of the following methods: anterior resection, laparoscopic anterior resection or abdominoperineal resection. In patients who were successively admitted to the Department of Surgical Oncology at the Oncology Center in Bydgoszcz, the impact of spine joint mobility, muscle strength and chest mobility on inhalation and exhalation wasassessed three times, i.e., at their admission and three and six months after surgery. The analysis included 72 patients (18 undergoing abdominoperineal resection, the APR group; 23 undergoing laparoscopic anterior resection, the LAR group; and 31 undergoing anterior resection, the AR group). The study groups did not differ in terms of age, weight, height, BMIor hospitalization time (p > 0.05). Three months after surgery, reductions in spine joint mobility regarding flexion, extension and lateral flexion, as well asreductions in the strength of the rectus abdominis and oblique muscles, were noted in all study groups (p < 0.05). In comparison between the groups, the lowest values suggesting the greatest reduction in the range of mobility were recorded in the APR group. Surgical treatment and postoperative management in colorectal cancer patients caused a reduction in spine mobility, abdominal muscle strength and chest mobility. The patients who experienced those changes most rapidly and intensively werethose undergoing abdominoperineal resection.

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Quantity and quality of muscle in patients recently diagnosed with colorectal cancer: a comparison with cancer-free controls

Cited by 5 publications

References 46 publications

Colorectal cancer pain upon diagnosis and after treatment: a cross-sectional comparison with healthy matched controls

Colorectal cancer pain upon diagnosis and after treatment: a cross-sectional comparison with healthy matched controls

Comparison of Muscle Mass Between Healthy Subjects and Patients With Malignant Tumors Undergoing Outpatient Treatment

The Impact of Surgical Techniques in Patients with Rectal Cancer on Spine Mobility and Abdominal Muscle Strength—A Prospective Study

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