Quantitatively Visualizing Assay of Drug Delivery System Using 2-Color Optical Coherence Dosigraphy

友, 中道; 壮一, 佐伯; 俊, 齊藤; 高史, 廣; 益徳, 松崎

doi:10.1299/kikaib.74.1572

Cited by 4 publications

(5 citation statements)

References 9 publications

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“…Therefore, it was confirmed that 2C-OCD can significantly detect cancerous tissue with selective uptake of photosensitizer. This result also suggested that the concentration of AlPcS accumulated in the tumor tissue was at least larger than 11.3 µM because our previous study (Nakamichi et al, 2008) revealed that current 2C-OCD system can detect AlPcS concentration with accuracy of ±11.3 µM. It was also confirmed that statistically significant differences (p < 0.001) were found for all combinations of averaged fluorescence intensities in tumor and normal sites.…”

Section: C-ocd Resultssupporting

confidence: 76%

“…Using photosensitizer as a contrast agent for OCT, 2C-OCD (Nakamichi et al, 2008(Nakamichi et al, , 2009) simultaneously detects tissue scattering coefficient and drug absorption coefficient from '2-color' OCTs having different optical absorbance of the photosensitizer. Al (III) phthalocyanine chloride tetrasulfonic acid (AlPcS) (Frontier Scientific Inc.) (Derycke et al, 2004;Juzenas et al, 2004;Kulvietis et al, 2007) is an oncotropic photosensitizer and has optical absorption peak at around 680 nm (Fig.…”

Section: -Color Optical Coherence Dosigraphymentioning

confidence: 99%

“…In practice, Eqs. (1)(2) showing spatial differentiations along depth axis for logarithmic OCT signal intensities I λ c (x, y, z) are investigated, (Nakamichi et al, 2008(Nakamichi et al, , 2009) for detail derivation of Eqs. (1)(2).…”

Section: -Color Optical Coherence Dosigraphymentioning

confidence: 99%

“…Previously, we proposed a micro-visualizing technique of drug distribution in vivo with micro-scale spatial resolution, which was termed 2-color optical coherence dosigraphy (2C-OCD) (Nakamichi et al, 2008(Nakamichi et al, , 2009). The dosigraphy is a coined term combining 'dosimetry' and 'tomography'.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

<i>In vivo</i> tomographically diagnosing technique of early cancer using 2-color optical coherence dosigraphy

Nakamichi

Saeki

Hiro

et al. 2017

JBSE

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The endoscopic optical coherence tomography (OCT) has been developed for early detection of digestive system cancer. However, it is difficult to detect cancerous tissue due to complicated speckle patterns contributed by optical properties of scattering and absorption in the morphological images of OCT. In our previous papers, 2-color optical coherence dosigraphy (2C-OCD) was proposed, which quantified OCT signal as scattering and absorption coefficients and could provide drug distribution at the micro-scale spatial resolution. In this study, an in vivo tomographically diagnosing technique of early cancer is presented, in which 2C-OCD is applied to cancerous tissue with selective uptake of photosensitizer. The feasibility study was demonstrated and investigated, based on 2C-OCD visualization of the subcutaneous tumor-implanted nude mice with photosensitizer AlPcS administered. Consequently, it was confirmed that drug absorption coefficient obtained by 2C-OCD was correlated with fluorescence intensity from accumulated AlPcS (r = 0.918), comparing with their histological images. Additionally, 2C-OCD could diagnose tumor tissue significantly with sensitivity of 82.5% and specificity of 78.3%, respectively. Therefore, 2C-OCD can detect photosensitizer infiltration into cancerous tissue, and thus has a promising modality for in vivo tomographically diagnosing technique of early cancer.

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Section: C-ocd Resultssupporting

confidence: 76%

Section: -Color Optical Coherence Dosigraphymentioning

confidence: 99%

Section: -Color Optical Coherence Dosigraphymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

<i>In vivo</i> tomographically diagnosing technique of early cancer using 2-color optical coherence dosigraphy

Nakamichi

Saeki

Hiro

et al. 2017

JBSE

Self Cite

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show abstract

“…11 Two-color optical coherence dosigraphy was recently developed to trace the distribution or delivery of a specific drug. 12 The combination of simultaneous light and ultrasound in intravascular imaging creates an innovative field of molecular imaging. Photo-acoustic imaging (opto-acoustic, or thermoacoustic imaging) uses a harmony of light and sound.…”

Section: Editorial Intravascular Molecular Imaging For Atherosclerosismentioning

confidence: 99%

Intravascular Molecular Imaging for Atherosclerosis

Hiro

2014

Circ J

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Imaging and quantitative analysis of water evaporation process using spectral-domain optical coherence tomography under illumination with two near-infrared wavelengths

Makino

Ujino

Lenggoro

et al. 2023

Opt Rev

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Quantitatively Visualizing Assay of Drug Delivery System Using 2-Color Optical Coherence Dosigraphy

Cited by 4 publications

References 9 publications

<i>In vivo</i> tomographically diagnosing technique of early cancer using 2-color optical coherence dosigraphy

<i>In vivo</i> tomographically diagnosing technique of early cancer using 2-color optical coherence dosigraphy

Intravascular Molecular Imaging for Atherosclerosis

Imaging and quantitative analysis of water evaporation process using spectral-domain optical coherence tomography under illumination with two near-infrared wavelengths

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