Quantitative variation in serum ceruloplasmin among ethnic groups

Abstract

Serum ceruloplasmin levels were determined enzymatically and immunochemically in Caucasians, Negroes, Orientals, and Amerindians. Orientals were found to have lower levels than either Negroes or Caucasians whereas the levels in Amerindians were higher. The differences were statistically significant at the 0.01 and 0.05 levels respectively.

Investigation on Huntington's disease

“…Serum caeruloplasmin was measured spectrophotometrically, as described by Shokeir (1970) by a method modified from Ravin (1961) and Cox (1966), and immunochemically (Shokeir 1970). Serum dopamine P-hydroxylase (DBH) levels were measured by the method of Weinshilboum & Axelrod (1971).…”

Investigations on the nature of ceruloplasmin deficiency in the newborn

“…This was achieved by double agar diffusion in tubes. For details of the above two methods, see Shokeir (1970). lrnmunoelectrophoresis and starch gel electrophoresis were used to ascertain the electrophoretic mobility of serum ceruloplasmin.…”

Identification of Several Electrophoretic Variants of Human Ceruloplasmin Including Cp^Michigan, a New Polymorphism

“…Cp oxidase activity is low in newborn infants and in creased in pregnant females [Matsuda et al" 1974]. Ethnic differences in immunochemically detectable Cp protein are noted [Shokeir, 1970], Several functions have been ascribed to Cp including (I) copper binding and transport and (2) as an oxidase with activity towards ferrous ions and bio genic amines [Gutteridge, 1978;Frieden and Hsieh, 1976;Poulik and Weiss, 1975]. The anemia associated with copper deficien cy could be explained by the inability of Cp to function as a 'ferroxidase' (EC 1.12.3.1) [Frieden and Hsieh, 1976;Mareschal et al, 1980].…”