Quantitative Untersuchungen der menschlichen Plazenta bei normaler Schwangerschaft und EPH-Gestose in Beziehung zum HPL-Serumspiegel im letzten Trimenon der Schwangerschaft

Abstract

Thirty-two human placentas from normal and from pregnancies complicated by preeclampsia in last third of gestation were morphologically and morphometrically examined and correlated with human placenta-lactogen blood-level. HPL was determined by the radio-immunoassay (Carbon-Dextran-method). HPL-values, placenta villous surface, the weight of the newborn and placenta showed significant correlation. The placentas were classified according to the morphologic degree of severity (placenta-morphological-index) and compared to preeclamptic index (Goecke) and HPL-values. The results showed correlation between the studied datas according to the severity of preeclampsia. The significance of these results is discussed.

Review article

“…4), we Interpret this reduction of mature syncytium äs a reduction in functional syncytium for placental hormone synthesis. Whereas these correlations are already known for placental weight and placental villous surface [7,11] our results correborate the "decreased function of endocrine trophoblast quality" äs postulated by BECKER [1], Linear regression analysis yields a correlation coefficient of r -0.52 between antepartum maternal HPL values and the proportion of mature syncytium [23]. This further demonstrates the quantitative relation between "functional" syncytium and hormone synthesis.…”

“…Identified are marginal (l, 2, 3, 5, 6,10,11,13,14,15), lateral[4,7,9,12] and central(8) sections äs well äs further subdivision in subchorial. intermediary, and basal zones.…”