Quantitative Untersuchungen �ber die blutzuckersteigernde Wirkung von synthetischem Oxytocin und Vasopressin sowie �ber das Auftreten dieses Hormoneffektes unter physiologischen Bedingungen

Heidenreich, O.; Kook, Y.; Reus, E.

doi:10.1007/bf00245104

Cited by 4 publications

(2 citation statements)

References 19 publications

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“…1). The time required to approach equilibration of body C02 pools (100-200 min) was appreciably less than with anaesthetized rams (Mirsky, 1963) and glucose (Heidenreich, Kook & Reus, 1962) and in the human to increase the heart rate, cardiac output and hand blood flow and to decrease the blood pressure (Kitchin, Lloyd & Pickford, 1959 H w E. F. ANNISON AND J. L. LINZELL nant sheep, the influence of oxytocin in our experiments was examined and in some experiments no oxytocin was given and the animal was not milked during the infusions.…”

Section: Resultsmentioning

confidence: 99%

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The oxidation and utilization of glucose and acetate by the mammary gland of the goat in relation to their over‐all metabolism and to milk formation

Annison¹,

Linzell²

1964

The Journal of Physiology

143

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It is well established that in ruminants dietary carbohydrate is largely fermented to short-chain fatty acids. Acetate, the major product of ruminal fermentation, is absorbed together with smaller amounts of propionate and butyrate to constitute a major source of energy. The paucity of alimentary glucose, when considered with the low concentrations of blood glucose and relative insensitivity to insulin which characterize ruminants, has tended to obscure the importance of glucose in ruminant metabolism. However, recent work based on the dilution of constantly infused isotope (Searle. Strisover & Chaikoff, 1954;Steele, Wall, de Bodo & Altszuler, 1956) has shown that rates of turnover and oxidation of glucose in sheep (Annison & White, 1961Bergman, 1963;Ford, 1963) and cattle (Davis & Brown, 1962) are not markedly lower than in non-ruminants. Similar studies with acetate have confirmed the quantitative importance of this substrate in ruminant metabolism and shown that, relative to glucose, acetate makes a two-to three-fold greater contribution to total oxidative metabolism in the intact animal (Annison, Brown, Leng, Lindsay, West & White, 1963).The dominant role of acetate in the over-all economy of ruminants is not reflected in the metabolism of all individual tissues. McClymont & Setchell (1956) demonstrated the uptake of glucose but not acetate by the sheep brain, and Annison, Scott & Waites (1963) showed that the testis and epididymis in the anaesthetized ram oxidize more glucose than acetate. Extensive studies on the metabolism of acetate and glucose by the isolated perfused mammary gland ofthe lactating goat have also shown that glucose is oxidized about twice as rapidly as acetate and is essential for milk secretion

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Section: Resultsmentioning

confidence: 99%

“…to ensure thorough emptying of the glands. However, oxytocin has been reported in rats to have an insulin-like activity in vitro on mammary tissue (Goodfriend & Topper, 1961), in dogs to raise the plasma levels of free fatty acids (Mirsky, 1963) and glucose (Heidenreich, Kook & Reus, 1962) and…”

Section: Resultsmentioning

confidence: 99%

The oxidation and utilization of glucose and acetate by the mammary gland of the goat in relation to their over‐all metabolism and to milk formation

Annison¹,

Linzell²

1964

The Journal of Physiology

143

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Untersuchungen �ber die Wirkungsweise der Hypophysenhinterlappenhormone auf den Kohlenhydrat- und Fettstoffwechsel

Heidenreich

Kook

Baumeister

et al. 1963

Naunyn - Schmiedebergs Arch

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Mechanisms of the stimulation of insulin release by oxytocin in normal mouse islets

Gao¹,

Drews²,

Henquin³

1991

Biochemical Journal

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Oxytocin (OT) produced a dose-dependent increase in somatostatin, glucagon and insulin release by isolated mouse islets. A small effect on somatostatin release was observed with 0.1 nM-OT, but 1-10 nM-OT was required to affect A- and B- cells significantly. The effects of OT on somatostatin and glucagon release were similar in the presence of 3 mM- and 10 mM-glucose. No change in insulin release was produced by OT in 3 mM-glucose, but a stimulation was still observed in the presence of a maximally effective concentration of glucose (30 mM). The increase in insulin release produced by OT (in 15 mM-glucose) was accompanied by small accelerations of 86Rb and 45Ca efflux from islet cells. Omission of extracellular Ca2+ accentuated the effect of OT on 86Rb efflux, attenuated that on 45Ca efflux, and abolished that on release. OT never inhibited 86Rb efflux. It did not affect the resting potential of B-cells, but slightly increased the Ca2(+)-dependent electrical activity induced by 15 mM-glucose. OT did not affect cyclic AMP levels, but increased inositol phosphate levels in islet cells. It is suggested that the amplification of glucose-induced insulin release that OT produces is due to a stimulation of phosphoinositide metabolism, and presumably an activation of protein kinase C, rather than to a change in cyclic AMP levels or a direct action on the membrane potential. Since OT is present in the pancreas, it is possible that it exerts a neuropeptidergic control of the islet function.

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Quantitative Untersuchungen �ber die blutzuckersteigernde Wirkung von synthetischem Oxytocin und Vasopressin sowie �ber das Auftreten dieses Hormoneffektes unter physiologischen Bedingungen

Cited by 4 publications

References 19 publications

The oxidation and utilization of glucose and acetate by the mammary gland of the goat in relation to their over‐all metabolism and to milk formation

The oxidation and utilization of glucose and acetate by the mammary gland of the goat in relation to their over‐all metabolism and to milk formation

Untersuchungen �ber die Wirkungsweise der Hypophysenhinterlappenhormone auf den Kohlenhydrat- und Fettstoffwechsel

Mechanisms of the stimulation of insulin release by oxytocin in normal mouse islets

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