Quantitative ultrasound using backscatter analysis in Duchenne and Becker muscular dystrophy

Zaidman, Craig M.; Connolly, Anne M.; Malkus, Elizabeth C.; Florence, Julaine; Pestronk, Alan

doi:10.1016/j.nmd.2010.06.019

Cited by 58 publications

(68 citation statements)

References 20 publications

(24 reference statements)

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“…As corroborated in the present study, the US method was able to provide data on the respiratory system of the preclinical GRMD model (Oliveira 2012). However, the methodology used in this study differs from previous reported approaches in DMD patients (Zaidman et al 2010, Jansen et al 2012) because echogenicity was not used for comparison but only to identify the diaphragm and intercostal muscles.…”

Section: Discussionsupporting

confidence: 55%

“…The Golden Retriever has been used as a model for studies on DMD in the recent years. Among these studies, the ultrasonography (US) has been used as a low-cost test and a non-invasive imaging method to enable the clinical assessment of patients, through the observation of the progress of the echogenicity intensity, caused by the evolution of tissue degeneration, providing efficient clinical data for monitoring these patients (Ahmad et al 2010, Jansen et al 2012, Zaidman et al 2010.…”

Section: Introductionmentioning

confidence: 99%

“…US is frequently used in the investigation and monitoring of musculoskeletal diseases and may be used to assess the progression of muscle loss in DMD due to its capacity to efficiently locate, detect and characterize tissue lesions (Sintzoff et al 1992, Ahmad et al 2010, Zaidman et al 2010, Jansen et al 2012. Distrophy causes muscle tissue degeneration and the muscular fibers are replaced by adipose tissue and collagen which increase the echogenicity, thus allowing the muscular margins to be determined by ultrasound (Zaidman et al 2010, Jansen et al 2012, Oliveira 2012.…”

Section: Introductionmentioning

confidence: 99%

“…Distrophy causes muscle tissue degeneration and the muscular fibers are replaced by adipose tissue and collagen which increase the echogenicity, thus allowing the muscular margins to be determined by ultrasound (Zaidman et al 2010, Jansen et al 2012, Oliveira 2012. In recent times, the US also has been employed to monitor the diaphragmatic movements in patients with respiratory diseases (Voyvoda et al 2012).…”

Section: Introductionmentioning

confidence: 99%

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Noninvasive evaluation of respiratory muscles in pre-clinical model of Duchenne Muscular Dystrophy

et al. 2016

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RESUMO.-[Avaliação não invasiva dos músculos respiratórios no modelo pré-clinico da Distrofia Muscular de Duchenne.] Uma vez que, a insuficiência respiratória é a principal causa de morte em pacientes afetados pela Distrofia Muscular de Duchenne (DMD), o presente estudo avaliou as condições clínicas cardiorrespiratórias, o movimento dos músculos intercostais, a mobilidade diafragmática, os ciclos respiratórios e a expansão da cavidade torácica em cães Golden Retriever com Distrofia Muscular (GRMD) por ultrassonografia (US) a fim de estabelecer um novo método não invasivo para avaliar os parâmetros de avaliação clínica de doenças respiratórias de modelos experimentais afetados por DMD. Um grupo controle constituído por cães da mesma raça e espécie, mas não afetados pela distrofia muscular também foram utilizados neste estudo. Os resultados mostraram que os movimentos de inspiração, expiração e platô (mobilidade do diafragma) foram menores no grupo afetado. A fase de platô no grupo afetado foi praticamente inexistente e mostrou que o diafragma destes animais permaneceu em constante movimento. A frequência respiratória atingiu 15,5 por minuto para o grupo afetado e 26,93 para o controle. Movimento de expiração e inspiração dos músculos intercostais atingiu 8,99 milímetros e 8,79 milímetros, respectivamente para o grupo controle e 7,42 milímetros e 7,40 milímetros, respectivamente para o grupo afetado. A metodologia utilizada nesta análise foi viável para o acompanhamento e avaliação do modelo respiratória em modelo GRMD e pode ser adaptado para outros modelos experimentais de distrofia muscular. Since respiratory insufficiency is the main cause of death in patients affected by Duchenne Muscular Dystrophy (DMD), the present study aims at establishing a new non-invasive method to evaluate the clinical parameters of respiratory conditions of experimental models affected by DMD. With this purpose in mind, we evaluated the cardiorespiratory clinical conditions, the changes in the intercostal muscles, the diaphragmatic mobility, and the respiratory cycles in Golden Retriever Muscular Dystrophy (GRMD) employing ultrasonography (US). A control group consisting of dogs of the same race, but not affected by muscular dystrophy, were used in this study. The results showed that inspiration, expiration and plateau movements (diaphragm mobility) were lower in the affected group. Plateau phase in the affected group was practically non-existent and showed that the diaphragm remained in constant motion. Respiratory rate reached 15.5 per minute for affected group and 26.93 per minute for the control group. Expiration and inspiration movements of intercostal muscles reached 8.99mm and 8.79mm, respectively, for control group and 7.42mm and 7.40mm, respectively, for affected group. Methodology used in the present analysis proved to be viable for the follow-up and evaluation of the respiratory model in GRMD and may be adapted to other muscular dystrophy experimental models.

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Section: Discussionsupporting

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Noninvasive evaluation of respiratory muscles in pre-clinical model of Duchenne Muscular Dystrophy

et al. 2016

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“…Although some attempts have recently been made to obtain a more reliable quantification of muscle abnormalities in Duchenne and Becker dystrophies by post processing (e.g. backscatter analysis, and entropy-based signal receipt), most of the current imaging experience in dystrophies is based on MRI [57,62,63].…”

Section: Musclementioning

confidence: 99%

Paediatric musculoskeletal US beyond the hip joint

et al. 2011

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US is a technique particularly suited to the investigation of musculoskeletal disorders in children and adolescents. This review paper describes a range of clinical settings beyond the hip joint where US has a significant role to play, including sports injuries, infectious diseases, inflammatory and degenerative conditions, congenital and developmental disorders, acute trauma of bone and joints, and peripheral nerve injuries. In some circumstances, US can be regarded as the most effective means of diagnostic imaging, whereas in other instances, it is an alternative or supplement to other more comprehensive imaging modalities, like MRI and CT. Although MRI offers superior soft-tissue contrast resolution, US is low-cost, non-invasive and has higher spatial resolution and real-time capability for the assessment of musculoskeletal structures during joint movement and stress manoeuvres.Keywords Ultrasound . Musculoskeletal system . Trauma . Child High-resolution US is particularly well suited to examine the paediatric musculoskeletal system. An exquisite depiction of the immature skeleton and soft tissues can be obtained in a well-tolerated and non-invasive way without using ionising radiation or sedation. Although US has been widely used in the diagnosis of hip disorders in children, many other applications for US of the paediatric musculoskeletal system have been developed [1,2]. Over other imaging techniques, US is ideally suited for the evaluation of tendons, muscles, joints, ligaments and nerves. In addition, it may provide specific information on bone and cartilage. In this article, we review the use of US in a variety of musculoskeletal applications beyond the hip, including sports injuries, infectious diseases, inflammatory and degenerative conditions, congenital and developmental disorders, acute trauma of bone and joints, and peripheral nerve injuries. Sports-related injuries Apophyseal injuriesIn children and adolescents, apophyseal injuries are commonly related to sporting and recreational activities. Especially in the age range between 12 and 16 years, the ossification centres of most apophyses are still immature and the cartilage, under hormonal influence, loses elasticity and is unable to give firm stability to the osteotendinous junction. Hence, the rough shear or torsion forces exercised upon them by tendons and ligaments can overcome the threshold of cartilage and bone resistance causing fragmenDisclaimer The supplement this article is part of is not sponsored by the industry. Dr.

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Quantitative muscle ultrasound detects disease progression in Duchenne muscular dystrophy

Zaidman

Kapur

et al. 2017

Annals of Neurology

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Objective We assessed changes in quantitative muscle ultrasound data in boys with Duchenne muscular dystrophy (DMD) and healthy controls to determine if ultrasound can serve as a biomarker of disease progression. Two approaches were used: grey scale level (GSL), measured from the ultrasound image, and quantitative backscatter analysis (QBA) measured directly from the received echoes. Methods GSL and QBA were obtained from six unilateral arm/leg muscles in 36 boys with DMD and 28 healthy boys (age 2–14 years) for up to 2 years. We used a linear mixed-effects model with random intercept and slope terms to compare trajectories of GSL, QBA, and functional assessments. We analyzed separately a subset of boys who initiated corticosteroids. Results Compared to healthy boys, increasing GSL in DMD boys >7.0 years was first identified at 6 months (e.g., anterior forearm slope difference of 1.16 arbitrary units/month p=0.004, 95% confidence interval (CI) [0.38,1.94]); in boys ≤7 years, differences in GSL first appeared at 12 months (0.82 arbitrary units /month, p=0.04 95%CI [0.075,1.565] in rectus femoris). QBA performed similarly to GSL (e.g., DMD boys >7 years of 0.41dB/month, p=0.01, 95%CI [0.096,0.72] in anterior forearm at 6 months). US identified differences earlier than functional measures including 6-minute walk and supine-to-stand tests. However, neither QBA nor GSL showed an effect of corticosteroid initiation. Interpretation QBA performs similarly to GSL and both appear more sensitive than functional assessments for detecting muscle deterioration in DMD. Additional studies will be required to determine if quantitative muscle ultrasound can detect therapeutic efficacy.

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Quantitative ultrasound using backscatter analysis in Duchenne and Becker muscular dystrophy

Cited by 58 publications

References 20 publications

Noninvasive evaluation of respiratory muscles in pre-clinical model of Duchenne Muscular Dystrophy

Noninvasive evaluation of respiratory muscles in pre-clinical model of Duchenne Muscular Dystrophy

Paediatric musculoskeletal US beyond the hip joint

Quantitative muscle ultrasound detects disease progression in Duchenne muscular dystrophy

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