Quantitative Ultrasound in the Management of Osteoporosis: The 2007 ISCD Official Positions

Krieg, Marc‐Antoine; Barkmann, R.; Gonnelli, Stefano; Stewart, Arthur D.; Bauer, Douglas C.; Barquero, Luís del Río; Kaufman, Jonathan J.; Lorenc, Roman; Miller, Paul D.; Olszynski, Wojciech P.; Poiană, Cătălina; Schott, Anne-Marie; Lewiecki, E. Michael; Hans, Didier

doi:10.1016/j.jocd.2007.12.011

Cited by 328 publications

(246 citation statements)

References 189 publications

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“…For this purpose, quantitative ultrasound techniques may represent an interesting tool for the identification of subjects at increased risk of fragility fractures [12,19]. The major finding of this study was that approximately one in four postmenopausal women in apparently good health, but with reduced SI, had sustained at least one vertebral fracture.…”

Section: Discussionmentioning

confidence: 78%

“…For this purpose, the last two decades have seen increased interest in using quantitative ultrasound techniques for the identification of subjects at increased risk of osteoporosis and fragility fractures [12,19]. Moreover, several studies have clearly documented the ability of quantitative ultrasound measurements at calcaneus to predict fragility fracture risk independently of bone mineral density [16,19,23].…”

Section: Introductionmentioning

confidence: 99%

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Undiagnosed Vertebral Fractures Influence Quality of Life in Postmenopausal Women With Reduced Ultrasound Parameters

Nuti

Caffarelli

Guglielmi

et al. 2014

Clinical Orthopaedics &Amp; Related Research

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Background Osteoporosis, a multifactorial systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue leading to increased bone fragility, is a worldwide public health problem. Vertebral fractures affect approximately 20% of postmenopausal women and are a hallmark of osteoporosis, but they may pass unnoticed, although they may lead to long-term immobility and disability. Questions/purposes The aims of the present study were (1) to determine the prevalence and the severity of vertebral fractures in a large cohort of Italian women aged 60 years or older with reduced values of quantitative ultrasound parameters; and (2) to assess whether vertebral fractures and other variables may be associated with health-related quality of life. Methods A total of 2450 women without back pain aged 60 years or older, after the completion of the Quality of Life Questionnaire of the European Foundation for Osteoporosis QUALEFFO, underwent quantitative ultrasound evaluation of the calcaneus; in those with a stiffness t-score of B À2 (n = 1194), radiographic evaluation of the thoracic and lumbar spine was carried out and then quantitative morphometry was performed by dedicated software (MorphoXpress). The radiographic analysis was carried out on 885 women who presented films of adequate quality. Multivariate regression was used to adjust for confounding variables. Results Of those who underwent radiographic analysis, 681 had no vertebral fractures, and 204 women (23.1%) had one or more previously undiagnosed vertebral fractures. The prevalence of previously undiagnosed vertebral fractures increased with advancing age with more than 30% of women older than 75 years having at least one fracture. Older age, body mass index, and severe vertebral fractures were independently associated with a worse total QUALEFFO score. Conclusions We found that approximately one in four women showed evidence of undiagnosed vertebral fractures, and there was a strong age effect trend. Moreover, the severity grade of vertebral fractures, more than the number of fractures, was associated with a worsening of healthrelated quality of life as assessed by QUALEFFO. These findings confirm the clinical relevance of an early diagnosis of vertebral fractures and seem to support the usefulness of quantitative ultrasound measurements in the stratification of postmenopausal women at increased fracture risk.

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Section: Discussionmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Undiagnosed Vertebral Fractures Influence Quality of Life in Postmenopausal Women With Reduced Ultrasound Parameters

Nuti

Caffarelli

Guglielmi

et al. 2014

Clinical Orthopaedics &Amp; Related Research

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“…The major limitation of QUS in inflammatory rheumatic disease is the proliferation of various types of QUS scanners based on different ultrasound principles and applied to a variety of anatomical sites (104), utilizing different ultrasound mechanisms such as trabecular transverse transmission mostly measured at the heel, cortical transverse transmission used at the phalanges, cortical axial transmission applicable to the phalanges, radius and tibia (62,105). Therefore, it is inappropriate to directly compare measurements acquired with different QUS devices which are technologically different.…”

Section: Limitations Of Qusmentioning

confidence: 99%

Clinical utilities of quantitative ultrasound in osteoporosis associated with inflammatory rheumatic diseases

Naganathan

et al. 2018

Quant. Imaging Med. Surg.

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Secondary osteoporosis is an important co-morbidity related to inflammatory rheumatic diseases that is attributed to several factors including inflammatory cytokines, inactivity and glucocorticoid treatment.Quantitative ultrasound (QUS) has been utilized in osteoporosis research due to its detectability of bone density as well as bone quality. The current narrative review is to address the potential utilities of QUS in secondary osteoporosis of inflammatory rheumatic diseases, focusing on the clinical aspects of QUS in these diseases, based on the conformity of QUS with dual emission X-ray absorptiometry (DXA), the relationship with disease characteristics, and its capability of fracture prediction. Although limited data demonstrate that QUS had moderate to strong correlation with DXA, and might be useful as a potential imaging tool to screen for osteoporosis, further research is still required for QUS to be utilized effectively for the best outcome in these patients with rheumatic diseases.

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“…Properties of the bone can be obtained by estimating and counting the differences between the sound waves transmitted into a bone and the wave emerging after interaction with the bone. The absence of ionizing radiation and the rapidity of examination in addition to cost savings may allow for QUS in widespread clinical use [18,19]. A number of radiographic and nuclear medicine techniques are also available for assessment of patients suspected of having osteoporosis or at risk for the development of the disease.…”

Section: Introductionmentioning

confidence: 99%

Importance of Recognition of Osteoporosis and the Radiologic Diagnosis Using DEXA Technique

Aldosh¹

2017

J Osteopor Phys Act

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Objective: Osteoporosis is the most common bone disease in humans; It is widely recognized as an important public health problem because of the significant morbidity, mortality and costs associated with its complications. The main objective of this study is to assess the osteoporosis disease and bone mineral density (MBD) in adults and menopausal patients and to estimate that osteoporosis can be prevented, diagnosed and treated before any fracture occur. Methods:This study was conducted in order to an intense effort to better recognition and understanding of osteoporosis disease and the importance of the medical radiologic diagnosis to preventing of osteoporotic fractures, using radiologic tools Dual energy x-ray absorptiometry (DEXA). Population of the study including male and female patient's age 18 years and older, whom underwent (DEXA) exam in period from September 2016 to March 2017. Results:The main results a proved that osteoporosis can be prevented, diagnosed and treated before any fracture occurs by using BMD test. The prevalent of osteoporosis reach 86 out of 136 scanned patients with DEXA with percentage (63.3%) with the score-2.5 or lower. Others results achieved that the big distribution an effected by osteoporosis were found in the elder age over 50 years. The results also achieved the common risk factors associate with postmen pause with percentage of 43.0% and the common patient's risk of fracture occur in the lumber spine by percentage of 45.4% a according to their T score. Conclusion:Although for many years there was awareness of the morbidity and mortality associated with fragility fractures, real progress only came with the ability to diagnose osteoporosis before fractures occur.

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Quantitative Ultrasound in the Management of Osteoporosis: The 2007 ISCD Official Positions

Cited by 328 publications

References 189 publications

Undiagnosed Vertebral Fractures Influence Quality of Life in Postmenopausal Women With Reduced Ultrasound Parameters

Undiagnosed Vertebral Fractures Influence Quality of Life in Postmenopausal Women With Reduced Ultrasound Parameters

Clinical utilities of quantitative ultrasound in osteoporosis associated with inflammatory rheumatic diseases

Importance of Recognition of Osteoporosis and the Radiologic Diagnosis Using DEXA Technique

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