Quantitative Ultrasound in the Assessment of Skeletal Status in Uremic Patients

Montagnani, A; Gonnelli, Stefano; Cepollaro, C.; Martini, Sergio; Finato, Viviana; Paolo, N. Di; Bellucci, G; Gennari, C

doi:10.1016/s1094-6950(06)60404-6

Cited by 29 publications

(12 citation statements)

References 21 publications

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“…Correlations between skeletal and laboratory measurements did not show any significant relationships, but the correlation coefficient between Ad-SoS and i-PTH (r = 70.29) is almost the same as that obtained in the study by Montagnani et al [7], who noted r = 70.28 with p<0.05. Probably the smaller size of our group prevented the correlation reaching significance.…”

Section: Discussionsupporting

confidence: 84%

“…Lately, bone mineral density (BMD) measurements have more often been applied for the diagnosis of renal osteodystrophy [4][5][6]. More recently, quantitative ultrasound (QUS) methods were introduced for the diagnosis of skeletal changes due to ESRF [4,[7][8][9][10][11]. QUS measurements can be performed in several sites of the skeleton, the most common being the calcaneus.…”

Section: Introductionmentioning

confidence: 99%

“…In 1992 a new ultrasound (US) technology was developed for measurements of the hand phalanges (DBM Sonic 1200, IGEA, Carpi, Italy). In some studies [4,7,8] these measurements allowed the detection of skeletal alterations in ESRF.…”

Section: Introductionmentioning

confidence: 99%

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Skeletal Status in Children, Adolescents and Young Adults with End-Stage Renal Failure Treated with Hemo- or Peritoneal Dialysis

Pluskiewicz¹,

Adamczyk²,

Drozdzowska³

et al. 2002

Osteoporosis International

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The skeletal status in 30 children, adolescents and young adults (18 females, 12 males) with end-stage renal failure (ESRF) aged 9-23 years (mean 15.8 +/- 3.6 years) was evaluated using measurements of bone mineral density (BMD, g/cm2) at the spine and total body (TB) (Lunar DPX-L, USA), quantitative ultrasound (QUS) of the hand phalanges (DBM Sonic 1200, IGEA, Italy) and laboratory investigations (parathyroid hormone, serum total and ionized calcium, serum phosphate). Eleven subjects were treated with hemodialysis and 19 with peritoneal dialysis. The mean value of the amplitude-dependent speed of sound (Ad-SoS, m/s) measured by QUS was significantly decreased in comparison with the value obtained in a group of 686 age-matched controls (1942 +/- 74 m/s vs 2050 +/- 77 m/s, p<0.0001). BMD measurements were also decreased in comparison with mean values for the healthy population (Z-scores for spine -1.47, and for TB -1.53). Duration of dialysis correlated significantly with spine-BMD, TB-BMD and Ad-SoS (r = -0.37, r = -0.45, r = -0.55, respectively, p<0.05), while duration of ESRF did not have such an influence. Laboratory investigations did not correlate with skeletal parameters. Ad-SoS correlated significantly with spine-BMD (r = 0.45, p<0.05) and TB-BMD (r = 0.56, p<0.01). Both QUS and BMD values correlated significantly with Tanner stages (r ranged from 0.59 to 0.69, p<0.001) and did not increase with age except for correlation between age and TB-BMD. In conclusion, skeletal status in the population studied is strongly affected by ESRF. Both QUS and BMD measurements show an ability to express skeletal changes in a similar manner, though the QUS parameter seems to be more sensitive at revealing changes due to renal failure.

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Section: Discussionsupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

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Skeletal Status in Children, Adolescents and Young Adults with End-Stage Renal Failure Treated with Hemo- or Peritoneal Dialysis

Pluskiewicz¹,

Adamczyk²,

Drozdzowska³

et al. 2002

Osteoporosis International

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“…Some preliminary studies seem to con®rm the possibility of obtaining a different pattern of signal in patients with osteoporosis or osteomalacia [33] or renal osteodystrophy [21].…”

Section: Discussionmentioning

confidence: 99%

“…Signal pattern analysis could provide further information on the physical characteristics of bone other than the traditional bone density assessed with X-ray methods. Preliminary studies have shown that the analysis of the ultrasound graphic trace could be particularly useful in studying metabolic bone diseases such as renal osteodystrophy [21], corticosteroid-induced bone loss [22] and bone alterations in rheumatoid arthritis [23].…”

Section: Introductionmentioning

confidence: 99%

Quantitative Ultrasound at the Phalanges in Healthy Italian Men

Montagnani

Gonnelli

Cepollaro

et al. 2000

Osteoporosis International

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In the last decade there has been a growing interest in quantitative ultrasound (QUS) techniques as a new method in the assessment of bone status in metabolic bone diseases. Many studies have shown that QUS parameters can predict vertebral and femoral fracture risk in patients with osteoporosis. However, most of the studies were performed in women, whereas few data are available for men. The aim of this study was to build up a normative database on a healthy Italian male population for QUS parameters at the phalanges. Amplitude-dependent speed of sound (AD-SoS) and three parameters (first wave amplitude, FWA; signal dynamic, SDy; time frame, TF) characterizing the graphic trace of the ultrasound signal were measured at the phalanges in 286 healthy subjects (age range 20-87 years). First, the QUS device was adapted to compensate for the difference in finger thickness between men and women. Preliminary data on 150 healthy subjects showed a significant difference between the traditional and adapted device, and the latter was independent of finger thickness variations. AD-SoS showed a significant (p<0.001) decrease with aging, expressed by a second-order polynomial equation. The peak value (2122 m/s) was observed in the fourth decade; thereafter it decreased to 1980 m/s at the ninth decade. Likewise, FWA and SDy were significantly (p<0.001) reduced after the fourth decade, whereas TF remained stable over time until the last decade. In conclusion, in men AD-SoS showed a negative trend with aging. The pattern with aging of parameters characterizing the graphic trace was different from the pattern for AD-SoS, suggesting the possibility of obtaining further information on phalanx bone physical properties which could be useful in the differential diagnosis of metabolic bone diseases and in the assessment of fracture risk.

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